The antimicrobial activity of 3,5,7-trihydroxyflavone isolated from the shoots of Helichrysum aureonitens

Afolayan, A. J.; Meyer, J.J.M.

doi:10.1016/s0378-8741(97)00065-2

Cited by 180 publications

(109 citation statements)

References 20 publications

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“…The IC50 value of the acetone leaf extract (0.13, 61.7%) is significantly higher than that of standard (vitamin C 0.30, 74.3%) the result is in agreement with Omoruyi et al (2012), who reported that IC50 values of methanol plant extract is significantly higher than that of BHT and Rutin. It was also revealed that the leaf extracts contain antioxidant properties than the bark extracts as shown in Table 2; this implies that most bioactive compound are stored on the trichomes which might probably be on the leaves as reported by Afolayan and Meyer (1997). This result shed more light on the scavenging potency of C. anisata and medicinal properties of this genus in South Africa which is in agreement with the report of York et al (2012).…”

Section: Abts Radical -Scavenging Activitysupporting

confidence: 85%

Phytochemical and antioxidant investigations of a Clausena anisata hook, a South African medicinal plant

Lawal¹,

Grierson²,

Afolayan³

2015

Afr. J. Trad. Compl. Alt. Med.

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Background: Clausena anisata (Willd). Hook (Rutaceae), also known as Iperepesi in Xhosa language is a medicinal plant widely used by herbalists for the treatment and/or management of several ailments such as chronic cough, tuberculosis and lung ulceration in Eastern Cape, South Africa. With reference to the information gathered in our previous study, we investigated the plant's phyto-constituents, as well as its inhibitory effects using aqueous and two different organic solvent of extractions in order to justify its folkloric usage. Methods: Antioxidant activity of the plant was screened through 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) diammonium salt, nitric oxide (NO), and ferric reducing power. Total phenols, flavonoids, flavonols, proanthocyanidins, tannins, alkaloids and saponins were investigated using spectroscopic techniques. Results: There were no significant differences in the flavonoid and proanthocyanidins contents between the leaves and bark extracts of C. anisata respectively, while the total phenolic content of the bark extract of C. anisata was significantly higher than that of the C. anisata leaf. The acetone extracts of both the leaf and bark indicated strong antioxidant activities. Conclusion:The observed activities of the plant extracts could be attributed to the high contents of the phenolics, alkaloids, flavonoids, saponins, proanthocyanidins and tannin. The acetone extracts of the plants have also exhibited strong antioxidant activities in vitro. It has been established scientifically that oxidative stress is linked with several degenerative conditions and diseases; the inhibitory effects of these plant extracts on the free radicals could logically justify the folkloric usage of C. anisata leaf and bark in the Eastern Cape for the treatment of respiratory infection diseases.

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Section: Abts Radical -Scavenging Activitysupporting

confidence: 85%

Phytochemical and antioxidant investigations of a Clausena anisata hook, a South African medicinal plant

Lawal¹,

Grierson²,

Afolayan³

2015

Afr. J. Trad. Compl. Alt. Med.

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“…Afolayan and Meyer (1997) isolated a flavone derivative, 3,5,7-trihydroxyflavone, with potent antimicrobial activity from H. aureonitens Sch. Bip.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial effect ofHelichrysum plicatumsubsp.plicatum

Demir¹,

Taban

Aslan

et al. 2009

Pharmaceutical Biology

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“…The agar medium containing the extracts at final concentrations of 0.1, 0.5, 1.0, 2.5, and 5.0 mg=ml were poured into Petri dishes, swirled carefully until the agar began to set. Plates were left overnight for the solvents to evaporate (Afolayan & Meyer, 1997). Plates containing 5 ml of acetone or methanol were used as controls (Dulger & Ugurlu, 2005).…”

Section: Preparation Of Agar-extract Platesmentioning

confidence: 99%

Medicinal Potential of the Root ofArctotis arctotoides.

Afolayan

Jimoh

Sofidiya

et al. 2007

Pharmaceutical Biology

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The antioxidant and antimicrobial activity of the acetone, methanol, and water extracts from the root of Arctotis arctotoides (L.f.) O. Hoffm (Asteraceae) were assessed in an effort to validate the medicinal potential of the subterranean part of the herb. The antioxidant activities of acetone and methanol extracts as determined by the ABTS, DPPH, and FRAP methods were higher than that of water extracts. The extracts showed significant activity against both Gram-positive and Gram-negative bacteria. The strongest activity was found in the acetone extract on Bacillus cereus, Staphylococcus aureus, Micrococcus kristinae, and Streptococcus pyrogens with an MIC of 0.1 mg=mL. Although not completely fungicidal, these extracts showed significant growth inhibition against all the fungi tested. Antioxidant and antimicrobial activities of the extracts were strongly correlated with total phenols and to a lesser extent with their flavonoids and proanthocyanidins contents. This study has validated the medicinal potential of the underground part of A. arctotoides.

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The antimicrobial activity of 3,5,7-trihydroxyflavone isolated from the shoots of Helichrysum aureonitens

Cited by 180 publications

References 20 publications

Phytochemical and antioxidant investigations of a Clausena anisata hook, a South African medicinal plant

Phytochemical and antioxidant investigations of a Clausena anisata hook, a South African medicinal plant

Antimicrobial effect ofHelichrysum plicatumsubsp.plicatum

Medicinal Potential of the Root ofArctotis arctotoides.

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