Abstract:Bitkilerden elde edilen doğal ürünler, kanser dahil çeşitli hastalıkların tedavisinde uzun yıllardır kullanılmaktadır. Centaurea solstitialis subsp. solstitialis'in Türk geleneksel tıbbında yeri olduğu bilinmektedir. Bu araştırma, Muğla ilinden toplanan C. solstitialis'in çiçekli kısımlarından elde edilen etanolik özütün in vitro biyolojik etkilerini belirleyen ilk çalışmadır. Gereç ve Yöntemler: Özütün Daudi, A549 ve HeLa kanser hücrelerine ve normal BEAS-2B hücre hattına karşı sitotoksik etkisi MTT (3-(4,5di… Show more
“…Moreover, Que is considered to be a chemopreventive that acts on signal transduction pathways as modulators to prevent, inhibit, or reverse carcinogenesis. By this activity, it shows many activities such as apoptosis, cell migration, differentiation and proliferation, oxidative balance, and inflammation . It also shows antioxidative activity and inhibits enzymes that activate carcinogens …”
Section: Results
and Discussionmentioning
confidence: 99%
“…By this activity, it shows many activities such as apoptosis, cell migration, differentiation and proliferation, oxidative balance, and inflammation. 183 It also shows antioxidative activity and inhibits enzymes that activate carcinogens. 184 2.2.1.1.…”
Quercetin
(Que) and its derivatives are naturally occurring phytochemicals with promising bioactive effects. The antidiabetic, anti-inflammatory, antioxidant, antimicrobial,
anti-Alzheimer’s, antiarthritic, cardiovascular, and wound-healing
effects of Que have been extensively investigated, as well as its
anticancer activity against different cancer cell lines has been recently
reported. Que and its derivatives are found predominantly in the Western
diet, and people might benefit from their protective effect just by
taking them via diets or as a food supplement. Bioavailability-related drug-delivery systems of Que
have also been markedly exploited, and Que nanoparticles appear as
a promising platform to enhance their bioavailability. The present
review aims to provide a brief overview of the therapeutic effects,
new insights, and upcoming perspectives of Que.
“…Moreover, Que is considered to be a chemopreventive that acts on signal transduction pathways as modulators to prevent, inhibit, or reverse carcinogenesis. By this activity, it shows many activities such as apoptosis, cell migration, differentiation and proliferation, oxidative balance, and inflammation . It also shows antioxidative activity and inhibits enzymes that activate carcinogens …”
Section: Results
and Discussionmentioning
confidence: 99%
“…By this activity, it shows many activities such as apoptosis, cell migration, differentiation and proliferation, oxidative balance, and inflammation. 183 It also shows antioxidative activity and inhibits enzymes that activate carcinogens. 184 2.2.1.1.…”
Quercetin
(Que) and its derivatives are naturally occurring phytochemicals with promising bioactive effects. The antidiabetic, anti-inflammatory, antioxidant, antimicrobial,
anti-Alzheimer’s, antiarthritic, cardiovascular, and wound-healing
effects of Que have been extensively investigated, as well as its
anticancer activity against different cancer cell lines has been recently
reported. Que and its derivatives are found predominantly in the Western
diet, and people might benefit from their protective effect just by
taking them via diets or as a food supplement. Bioavailability-related drug-delivery systems of Que
have also been markedly exploited, and Que nanoparticles appear as
a promising platform to enhance their bioavailability. The present
review aims to provide a brief overview of the therapeutic effects,
new insights, and upcoming perspectives of Que.
“…According to this study, the highest cytotoxic activity was observed in the Hela cell line with an IC50 value of 63.18 µg/mL while the lowest cytotoxic activity was observed in the A549 cell line with an IC50 value of 252.5 µg/mL. However, it was reported that the IC50 value of 75.25 µg/mL was detected in the BEAS2b normal cell line [27]. In a study by Yirtici et al, it was stated that C. fenzlii Reichardt extract had an inhibitory effect on the MCF-7 cell line.…”
The aim of this study was to investigate in vitro cytotoxic effects of previously isolated compounds (taraxasterol, salvigenin, 3'-O-methyleupatorin, oleanolic acid, jaceosidin and pectolinarigenin) from Centaurea kilaea chloroform extract on hepatocellular carcinoma cell lines, HepG2 and Hep3B, as well as to evaluate the effect on the normal cell line, NIH3T3. In vitro antihepatocellular carcinoma activity of compounds was assessed by MTT method. All compounds except pectolinarigenin caused more inhibition on HepG2 rather than Hep3B. Among these compounds, it was found that Jaseosidin had the highest anticancer activity with IC50 values of 137.66 µg/mL and 147.66 µg/mL on the HepG2 and Hep3B cell lines, respectively. 3'-O-methyleupatorin showed the second highest cytotoxicity with IC50 values of 151.98 µg/mL and 159.24 µg/mL against the HepG2 and Hep3B cell lines, respectively. The results indicated that Jaseosidin and 3'-O-methyleupatorin, had the best antiproliferative activity against hepatocellular carcinoma cell lines. Also, according to our best knowledge, this study is first report on antihepatocellular carcinoma activity of Jaseosidin and 3'-O-methyleupatorin.
“…Our results suggested that these extracts have more cytotoxic potentials against MCF-7 and PC-3 cancer cell lines than against HEK293 cell lines, in other words the cancer cell lines used herein were more sensitive to both extracts than HEK293 cell line. In contrast, the IC50 values of the ethanolic extract of the flowering parts of C. solstitialis on HeLa (cervix adenocarcinoma), Daudi (Burkitt's lymphoma, CCL-213), A549 (lung adenocarcinoma) and BEAS-2B (normal bronchial epithelium) human cell lines at 72 h were reported to be 63.18, 69.27, 252.5 and 75.25 μg mL -1 , respectively [7]. Erenler and coauthors [47] stated that, at 500 μg mL -1 , the methanolic extract of stem parts of C. solstitialis L. ssp.…”
Section: Discussionmentioning
confidence: 94%
“…Centaurea L., which is a medicinal genus belonging to the Asteraceae family, is represented with 217 taxa 60% of which are endemic to Turkey [2]. Members of this genus were proposed to have several biological activities such as antioxidant [3,4], antimicrobial [5] and antiproliferative [6,7] effects. Centaurea solstitialis L. (yellow star thistle) which grows all over Turkey is used for herpes infections around the lips, malaria, upset stomachs, common colds, hemorrhoids, peptic ulcer and abdominal pain [8][9][10][11].…”
It is known that some genera of the Asteraceae family are commonly used in Turkish folk medicine. Several studies have investigated the biological effects of different extracts of Centaurea and Urospermum species, but studies involving the phenolic composition of C. solstitialis and U. picroides extracts are very limited. This study aimed to investigate the phenolic composition and antioxidant activity of C. solstitialis and U. picroides and evaluate their possible cytotoxic effect. RP-HPLC analysis was used to elucidate the phenolic profiles of the ethanolic extracts of flowering parts of C. solstitialis and U. picroides.The both ethanolic extracts were assessed for their antioxidant properties using DPPH, FRAP, phosphomolybdenum and metal chelating assays. Furthermore, the effect of the extracts on cell viability was evaluated against MCF-7 and PC-3 cancer cells and HEK293 cell line using the MTT assay. The most abundant phenolic compound in both extracts was determined to be caffeic acid, and the amount of this compound was 24078.03 HIGHLIGHTS The phenolic composition, antioxidant activity and cytotoxic potential of the extracts of C. solstitialis and U. picroides were investigated. Caffeic acid was found as the most abundant phenolic compound in the extracts. Both species showed promising antioxidant activity towards different assays. The highest cytotoxic potential was observed in the extract of C. solstitialis.
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