The antiandrogenic activity of pyrethroid pesticides cyfluthrin and β-cyfluthrin

The association between environmental exposure to pyrethroids and sperm aneuploidy

“…Pyrethroids may affect estrogen receptors in Sertoli cells (Taylor et al, 2010) and have antiandrogenic effects by antagonizing the androgen receptor and affecting seminal vesicle weight (Zhang et al, 2008). Several animal studies show links between pyrethroids exposures and sperm function, including sperm capacitation, semen quality and sperm motility (Yuan et al, 2010).…”

Distribution, Metabolism and Toxic Effects of Beta-Cypermethrin in Lizards ( Eremias argus ) Following Oral Administration

“…Now it is accounting for approximately 25% of the worldwide insecticide market [2]. Moreover, since the 1980s, Beta-cypermethrin (BCYP), a synthetic PYR pesticide which is a mixture of the alpha and theta forms, has been widely used and comprises more than 50% of the total PYR market production in China [3][4][5]. Before the commercialization of pesticide, the registration usually requires submitting some toxic data to a regulatory agency.…”

Endocrine disruptive action of cypermethrin in male mice

“…Earlier studies showed histopathological changes in the testes, disorganization of spermatogenesis, reduced diameter of tubules, sperm counts and testosterone levels in rats, mice and rabbits following treatment with CYP 3,4,6,[9][10][11]17 . Since these studies did not focus on alterations if any in different stages of spermatogenesis, whether CYP targets specific stages or affects all the stages could not be ascertained form these reports.…”

“…Hence any disruption of the hormonal mechanism might impair spermatogenic activity and also adversely affect the androgen dependent organs. The endocrine disruptive action of CYP is evidenced by its anti-androgenic activity 17 , interference with testosterone biosynthesis via down-regulating the expression of steroidogenesis acute regulatory protein (StAR) in the testis 10 , and reduced serum levels of testosterone following CYP treatment in rat, mice and rabbits 3,4,10 . In the present study the endocrine disruptive action of CYP was evident by the fact that it significantly reduced the serum levels of testosterone (all doses, both durations) and reduced weight of the androgen dependent accessory reproductive organs viz epididymis, vas deference, seminal vesicle and prostate gland and caused morphological regression of the epididymis, i.e.…”

“…Dipping the whole body of dwarf goat in 0.1%, 0.4% 0.8% and 1.6% CYP per day for 45 or 75 days caused a significant decrease in ejaculate volume, sperm concentration and sperm motility and a significant increase in abnormal and dead spermatozoa 7 . An increase in the height of the seminal gland epithelium and epithelial cell proliferation were found following administration (ip) of 485 mg CYP/kg bw for 1,9,17,26, and 34 days in mice 8 . Daily treatment with 20 mg/kg bw beta-CYP by gavage for 35 days impaired reproductive function by inducing oxidative stress 9 and daily treatment with 25 mg/kg bw CYP during puberty (postnatal day 35 to 70) disturbed testosterone synthesis via downlregulating the expression of steroidogenesis acute regulatory protein (StAR) and steroidogenic enzymes in the testes in mice 10 .…”