The association between environmental exposure to pyrethroids and sperm aneuploidy

Radwan, Michał; Jurewicz, Joanna; Wielgomas, Bartosz; Piskunowicz, Marta; Sobala, Wojciech; Radwan, Paweł; Jakubowski, Lucjusz; Hawuła, Wanda; Hanke, Wojciech

doi:10.1016/j.chemosphere.2014.12.077

Cited by 51 publications

(26 citation statements)

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“…Study of Raimondi et al (1989) reports 10-fold increase in the loss of the chromosome 9 after exposure of human peripheral blood lymphocytes to benomyl, a benzimidazole derivative. Such significant effect on gonosome frequency in individuals exposed to imidacloprid has been reported by Radwan et al (2015).…”

Section: Discussionmentioning

confidence: 75%

Chromosome Missegregation and Aneuploidy Induction in Human Peripheral Blood Lymphocytes In vitro by Low Concentrations of Chlorpyrifos, Imidacloprid and α‐Cypermethrin

Mužinić

Ramić

Želježić

2018

Environ and Mol Mutagen

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Chlorpyrifos, imidacloprid, and α‐cypermethrin are some of the most widely used insecticides in contemporary agriculture. However, their low‐dose, nontarget genotoxic effects have not been extensively assayed. As one of the most relevant cancer biomarkers, we aimed to assess the aneuploidy due to chromosome missegregation during mitosis. To aim it we treated human lymphocytes in vitro with three concentrations of insecticides equivalents relevant for real scenario exposure assessed by regulatory agencies. We focused on chlorpyrifos as conventional and imidacloprid and α‐cypermethrin as sustainable use insecticides. Cytokinesis‐blocked micronucleus assay was performed coupled with fluorescence in situ hybridization (FISH) with directly labeled pancentromeric probes for chromosomes 9, 18, X and Y. None of the insecticides induced significant secondary DNA damage in terms of micronuclei (MN), nuclear buds (NB), or nucleoplasmic bridges (NPB). However, significant disbalances in chromosomes 9, 18, X and Y, and in insecticide‐treated cells has been observed. According to recent studies, these disbalances in chromosome numbers may be atributted to defect sister chromatid cohesion which contribute to the increase of chromosome missegregation but not to micronuclei incidence. We conclude that tested insecticidal active substances exert chromosome missegregation effects at low concentrations, possibly by mechanism of sister chromatid cohesion. These findings may contribute to future risk assesments and understanding of insecticide mode of action on human genome. Environ. Mol. Mutagen. 60:72–84, 2019. © 2018 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 75%

Chromosome Missegregation and Aneuploidy Induction in Human Peripheral Blood Lymphocytes In vitro by Low Concentrations of Chlorpyrifos, Imidacloprid and α‐Cypermethrin

Mužinić

Ramić

Želježić

2018

Environ and Mol Mutagen

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“…Pyrethroids may cause sperm aneuploidy (94). Organophosphates and carbamates can act on semen quality and sex hormones, increasing thyroid-stimulating hormone (TSH) and luteinizing hormone (LH) blood levels (95).…”

Section: Reproductive Disordersmentioning

confidence: 99%

Occupational exposure to pesticides as a possible risk factor for the development of chronic diseases in humans

Gangemi

Miozzi

Teodoro

et al. 2016

Molecular Medicine Reports

138

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It is well known that pesticides are widely used compounds. In fact, their use in agriculture, forestry, fishery and the food industry has granted a huge improvement in terms of productive efficiency. However, a great number of epidemiological surveys have demonstrated that these toxic compounds can interact and exert negative effects not only with their targets (pests, herbs and fungi), but also with the rest of the environment, including humans. This is particularly relevant in the case of workers involved in the production, transportation, preparation and application of these toxicants. Accordingly, a growing body of evidence has demonstrated the correlation between occupational exposure to pesticides and the development of a wide spectrum of pathologies, ranging from eczema to neurological diseases and cancer. Pesticide exposure is often quite difficult to establish, as many currently used modules do not take into account all of the many variables that can occur in a diverse environment, such as the agricultural sector, and the assessment of the real risk for every single worker is problematic. Indeed, the use of personal protection equipment is necessary while handling these toxic compounds, but education of workers can be even more important: personal contamination with pesticides may occur even in apparently harmless situations. This review summarises the most recent findings describing the association between pesticide occupational exposure and the development of chronic diseases.

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“…Study participants provided urine, saliva, and semen samples on the same day. Full details of the parent study have been described elsewhere ( Radwan et al, 2015 ).…”

Section: Methodsmentioning

confidence: 99%

Air Pollution and Human Sperm Sex Ratio

Radwan

Dziewirska

Radwan³

et al. 2018

Am J Mens Health

Self Cite

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The present study was designed to address the hypothesis that exposure to specific air pollutants may impact human sperm Y:X chromosome ratio. The study population consisted of 195 men who were attending an infertility clinic for diagnostic purposes and who had normal semen concentration of 15–300 mln/ml (WHO, 2010). Participants represented a subset of men in a multicenter parent study conducted in Poland to evaluate environmental factors and male fertility. Participants were interviewed and provided a semen sample. The Y:X ratio was assessed by fluorescent in situ hybridization (FISH). Air quality data were obtained from the AirBase database. In multivariate analysis the significant reduction was observed in the proportion of Y/X chromosome bearing sperm and exposure to particulate matter >10 μm in aerodynamic diameter PM10 (p = .009) and particulate matter <10 μm in aerodynamic diameter PM2.5 (p = .023). The observed effects of a lower Y:X sperm chromosome ratio among men exposed to air pollution support the evidence that the trend of declining sex ratio in several societies over past decades has been due to exposure to air pollution; however due to limited data on this issue, the obtained results should be confirmed in longitudinal studies.

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The association between environmental exposure to pyrethroids and sperm aneuploidy

Cited by 51 publications

References 50 publications

Chromosome Missegregation and Aneuploidy Induction in Human Peripheral Blood Lymphocytes In vitro by Low Concentrations of Chlorpyrifos, Imidacloprid and α‐Cypermethrin

Chromosome Missegregation and Aneuploidy Induction in Human Peripheral Blood Lymphocytes In vitro by Low Concentrations of Chlorpyrifos, Imidacloprid and α‐Cypermethrin

Occupational exposure to pesticides as a possible risk factor for the development of chronic diseases in humans

Air Pollution and Human Sperm Sex Ratio

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