The Anti-ulcerogenic Effect of an Alkaloidal Fraction from <i>Mikania cordata</i> on Diclofenac Sodium-induced Gastrointestinal Lesions in Rats

Mosaddik, Ashik; Alam, Kh. Md. Faisal

doi:10.1211/0022357001774930

Cited by 18 publications

(15 citation statements)

References 20 publications

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“…In the study realized by Paul et al (2000) the alkaloid fraction obtained from an ethanolic extract of leaves of Mikania cordata (dose 50 mg/kg) exhibited antiulcer activity (in vivo) in gastric erosions induced by diclofenac sodium in rats Long Evans. Mosaddik & Alam (2000) carried out a similar study to evaluate the role of alkaloids fraction in gastric erosions induced by diclofenac sodium in rats Long Evans and found that in the alkaloidal-administered group (50 mg/ kg) the ulcer index of the stomach (0.268±0.0346) and of the duodenum (0.050±0.0129) were significantly lower than the diclofenac-only administered group (0,691±0,0184 and 0.093±0.0346, respectively). Thus, bioactive principles of M. cordata have proved antiulcerogenic effects.…”

Section: Activity In the Digestive Systemmentioning

confidence: 99%

Genus Mikania: chemical composition and phytotherapeutical activity

Rufatto¹,

Gower²,

Schwambach³

et al. 2012

Rev. bras. farmacogn.

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Abstract:The genus Mikania ranks high in the list of best-selling natural products in the world. Its main distribution is in South America, but some species are found in Asia, North America and Africa. It is used for treating fever, rheumatism, colds and respiratory diseases, as well as snake bites and scorpion stings, due to its broad spectrum of action. There are approximately 430 species of this genus and only 12% have been studied, highlighting their chemical and pharmacological diversity. The main chemical groups are: coumarins and derivatives, sesquiterpenes, sesquiterpenes lactones, diterpenes, phytosterols/terpenoids and flavonoids. This review aims to supply useful references for scientists interested in natural products and the search for new compounds, from over the 300 already described for the genus.

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Section: Activity In the Digestive Systemmentioning

confidence: 99%

Genus Mikania: chemical composition and phytotherapeutical activity

Rufatto¹,

Gower²,

Schwambach³

et al. 2012

Rev. bras. farmacogn.

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“…Three deterpenic acids known as kaurenic acid, butyryloxykaurenic acid and benzoyloxykaurenic acid, stigmasterol and betasitosterin have also been isolated from this plant [4] . The plant is reported to have psychopharmacological and neuropharmacological properties; antimicrobial, antiinflammatory, antipyretic, ulcerprotective, anticarcinogenic activities [5][6][7][8] . But still no scientific and methodical investigation has so far been reported in literature regarding its analgesic and antioxidant action.…”

Section: Introductionmentioning

confidence: 99%

Analgesic and Antioxidant Activity of the Hydromethanolic Extract of Mikania scandens (L.) Willd. Leaves

Hasan¹,

Jamila²,

Majumder³

et al. 2009

American J. of Pharmacology and Toxicology

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Problem statement:Mikania scandens (L.) Willd., a medicinal plant, is popularly used as herbal remedy for various ailments in Bangladesh. But the scientific basis for its medicinal use especially in pain and inflammation remains unknown. Therefore, the present study was designed to evaluate analgesic and antioxidant potential of the hydromethanol extract of the leaves of the plant. Approach: The analgesic activity was determined for its central and peripheral pharmacological actions using hotplate and tail immersion method and acetic acid-induced writhing test in mice respectively. The hydromethanol extract was also investigated for its antioxidant action using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, Nitric Oxide (NO) scavenging and reducing power assays. Results: The extract, at the dose of 250 and 500 mg kg −1 , produced a significant (p<0.05) increase in pain threshold in hotplate and tail immersion methods in a dose dependent manner. In acetic acid-induced writhing test, the extract (500 mg kg −1 ) produced a maximum of 53.73% inhibition (p<0.001) of writhing reaction compared to the reference drug Diclofenac-Na (76%). A dose dependent scavenging of DPPH radical and NO was observed with good reducing power with the extract. In DPPH radical scavenging assay, the IC 50 value of the extract was 375.40 µg mL −1 while the IC 50 value for the reference ascorbic acid was 55.89 µg mL −1 . The IC 50 values of the extract and ascorbic acid were 220.43 and 125.10 µg mL −1 , respectively in NO scavenging assay. Conclusion: The findings of the study suggested that the extract from Mikania scandens has strong analgesic and antioxidant effects.

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“…It is popularly known as "guaco" and possess pharmacological properties for treating the airways [1,2] . M. laevigata also possesses antimicrobial, [3] inflammatory, bronchodilator, antispasmodic, antirheumatic and antiulcerant activities [4,5] .…”

Section: Introductionmentioning

confidence: 99%

Isolation and identification of endophytic fungi in the medicinal plant Mikania laevigata (Asteraceae)

Ribeiro¹,

Kamida²,

Almeida³

et al. 2014

Phcog J.

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The Mikania laevigata (Asteraceae) is a Brazilian medicinal plant used to treat respiratory tract diseases. It is produced on a large scale for phytotherapic formulation. No studies on the endophytes of Mikania laevigata have been described in the literature. The endophytic fungi isolated from the leaves of M. laevigata cultivated in a floral garden located in the south region of the Bahia state, Brazil, were investigated. After surface disinfection, the performing the isolation procedure, a total of forty endophytic fungi were obtained and grouped into different morphospecies. The fungi were characterized by molecular sequencing the ITS rDNA regions, and they were identified by comparing the results published Gen Bank sequences.The phylogenetic analyses revealed four major clades of fungi from the sequenced ITS-rDNA regions: Nodulisporium sp. (3 isolates), Hypoxylon sp. (3 isolates), Daldinia sp. (1 isolate) and Xylaria luteostromata (aunique isolate).The Xylariaceae Genus was the dominant group of fungi associated with Mikania laevigata.

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The Anti-ulcerogenic Effect of an Alkaloidal Fraction from Mikania cordata on Diclofenac Sodium-induced Gastrointestinal Lesions in Rats

Cited by 18 publications

References 20 publications

Genus Mikania: chemical composition and phytotherapeutical activity

Genus Mikania: chemical composition and phytotherapeutical activity

Analgesic and Antioxidant Activity of the Hydromethanolic Extract of Mikania scandens (L.) Willd. Leaves

Isolation and identification of endophytic fungi in the medicinal plant Mikania laevigata (Asteraceae)

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