The anti-inflammatory effects of statins on patients with rheumatoid arthritis: A systemic review and meta-analysis of 15 randomized controlled trials

Li, Guomin; Zhao, Jie; Li, Bing; Zhang, Xiaofei; Ma, Jianxiong; Ma, Xinlong; Li, Jun

doi:10.1016/j.autrev.2017.10.013

Cited by 93 publications

(54 citation statements)

References 36 publications

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“…The results here obtained, suggest that Nigella sativa treatment lowers the levels of TC, which, in turn, decrease the degree of inflammation, restoring normal CRP and IL-6 levels. A similar effect was described in arthritic patients treated with statins, where a lower degree of inflammation with clinical improvements in RA was reported in conjunction with decreased plasma TC and CRP levels [42]. K-medoids clustering analysis applied to all hematological data collected on day 15 identified 4 categories: Cluster 3 was composed mostly of control and CFA + indomethacin samples, clusters 1, 2 and 4 included those related to CFA group, and in all these clusters, samples belonging to both CFA + Nigella sativa groups were found.…”

Section: Discussionsupporting

confidence: 72%

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Anti-Inflammatory, Anti-Arthritic and Anti-Nociceptive Activities of Nigella sativa Oil in a Rat Model of Arthritis

et al. 2019

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This study investigated the preventive efficacy of the crude oil extracted from Nigella sativa seeds in a rat model of arthritis induced by using complete Freund’s adjuvant (CFA). Nigella sativa oil at 1.82 mL/kg or 0.91 mL/kg (corresponding to 1596 and 798 mg/kg, respectively) was orally administered for 25 days from the day of immunization. One immunized group was treated orally with indomethacin (3 mg/kg) as a reference drug. Body weight growth rate, paw swelling, arthritis score, mechanical allodynia, locomotor activity and anxiety-like behavior were observed, and the levels of Interleukin 6 (IL-6), C-reactive protein, albumin and total cholesterol in plasma were measured on days 15 and 25. Nigella sativa oil showed anti-inflammatory, anti-arthritic and anti-nociceptive activities that were significant as compared to untreated arthritic rats but less than indomethacin. These results indicated that Nigella sativa oil significantly attenuated adjuvant-arthritis in rats and the higher dose (1.82 mL/kg) prevented the development of arthritis with an inhibition of 56%.

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Section: Discussionsupporting

confidence: 72%

“…In the light of previous evidences suggesting a hypocholesterolemic effect of Nigella sativa [41] and considering the positive effect of hypolipidemic drugs in RA [42], we decided to measure TC plasma levels in rats. The CFA group did not show any increase in TC levels with respect to control healthy rats.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory, Anti-Arthritic and Anti-Nociceptive Activities of Nigella sativa Oil in a Rat Model of Arthritis

et al. 2019

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“…Three-hydroxy-3-methyl-glutaryl-coenzyme A (HMG co-A) reductase inhibitors (statins) are effective and commonly used worldwide as a treatment for dyslipidemia, and increasing evidence shows that statins also have anti-inflammatory and anti-oncogenic effects [5,6].…”

Section: Introductionmentioning

confidence: 99%

Statin Use Decreases the Incidence of Hepatocellular Carcinoma: An Updated Meta-Analysis

Facciorusso

Aziz

Singh

et al. 2020

Cancers

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Statins can decrease hepatocellular carcinoma (HCC) occurrence, but the magnitude and the predictors of these effects remain unclear. This meta-analysis provides a pooled estimate of the impact of statin use on HCC occurrence. Pooled effects were calculated using a random-effects model by means of the DerSimonian and Laird test. Primary endpoint was the time-dependent correlation between statin use and HCC incidence expressed as hazard ratio (HR), both crude and adjusted. The crude and adjusted odds ratios (OR) for HCC occurrence between statin users and non-users were analyzed. Twenty-five studies with 1,925,964 patients were included. Crude OR for HCC incidence was 0.59 (95% CI: 0.47–0.74), confirmed in adjusted analysis (OR: 0.74, 95% CI: 0.70–0.78). Adjusted HR was 0.73 (95% CI: 0.69–0.76). This effect was more pronounced in HBV patients (HR: 0.46, 95% CI: 0.36–0.60) and with a cumulative daily dose beyond 365 (HR: 0.27, 95% CI: 0.11–0.67). Lipophilic statins were associated with reduced HCC incidence (HR: 0.49, 95% CI: 0.39–0.62). Atorvastatin determined the greater magnitude of effect (HR: 0.43, 95% CI: 0.28–0.65). This meta-analysis demonstrates the beneficial chemopreventive effect of statins against HCC occurrence. This effect is dose-dependent and more pronounced with lipophilic statins.

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“…27 Furthermore, statins may beneficially affect RA disease activity, mainly due to their antiinflammatory and immunomodulatory properties. 28,29 This has been already suggested more than a decade ago. 30…”

mentioning

confidence: 86%

Methotrexate for Cardiovascular Risk Reduction: The Right Choice?

et al. 2019

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The anti-inflammatory effects of statins on patients with rheumatoid arthritis: A systemic review and meta-analysis of 15 randomized controlled trials

Cited by 93 publications

References 36 publications

Anti-Inflammatory, Anti-Arthritic and Anti-Nociceptive Activities of Nigella sativa Oil in a Rat Model of Arthritis

Anti-Inflammatory, Anti-Arthritic and Anti-Nociceptive Activities of Nigella sativa Oil in a Rat Model of Arthritis

Statin Use Decreases the Incidence of Hepatocellular Carcinoma: An Updated Meta-Analysis

Methotrexate for Cardiovascular Risk Reduction: The Right Choice?

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