The anti-inflammatory effects of sanguinarine and its modulation of inflammatory mediators from peritoneal macrophages

Niu, Xiaofeng; Fan, Ting; Liu, Weifeng; Wei, Xing

doi:10.1016/j.ejphar.2012.05.039

Cited by 100 publications

(65 citation statements)

References 45 publications

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“…Previous studies have indicated a promising anti-inflammatory effect for sanguinarine (1) and chelerythrine (2) both in vitro and in vivo (Niu et al 2011;Niu et al 2012;Pencikova et al 2012). The results obtained in this study indicate that the presence of a methylenedioxy ring attached at C7-C8 is important for reducing the secretion of TNF-α.…”

Section: Discussionmentioning

confidence: 99%

“…The inhibition of two important enzymes, 5-and 12-lipoxygenase, has also been described (Vavreckova et al 1996). Niu et al (2012) described significant anti-inflammatory effects of sanguinarine both in vitro, in lipopolysaccharide (LPS)-stimulated peritoneal macrophages, and in vivo, in acute and chronic inflammatory models. Sanguinarine also attenuated pulmonary histological changes and lung oedema in mice, and reduced the myeloperoxidase activity after LPS stimulation and the neutrophil infiltration in the lung.…”

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confidence: 99%

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The capability of minor quaternary benzophenanthridine alkaloids to inhibit TNF-α secretion and cyclooxygenase activity

et al. 2017

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Quaternary benzophenanthridine alkaloids are known to have a wide range of biological effects, including antimicrobial, antifungal, anti-inflammatory, and antitumour activities. However, only sanguinarine and chelerythrine have been studied intensively. The aim of this study was to evaluate the anti-inflammatory potential of the five minor quaternary benzophenanthridine alkaloids sanguilutine, sanguirubine, chelirubine, chelilutine, and macarpine in vitro and to compare them with more thoroughly studied sanguinarine and chelerythrine. Before making cellbased assays, the cytotoxicity of the alkaloids was evaluated. The anti-inflammatory potential of the chosen alkaloids was evaluated as for their ability to modulate the lipopolysaccharideinduced secretion of tumour necrosis factor α (TNF-α) in the macrophage-like cell line THP-1. The cyclooxygenase (COX)-1 and COX-2 inhibitory activities were also measured. The results indicate that the presence of a methylenedioxy ring attached at carbon (C)7-C8 is important for reducing the secretion of TNF-α. Interestingly, this effect did not show a simple dependence on concentration. The selected alkaloids showed little or no anti-COX activity. The results obtained from the present experiments may provide additional information useful in understanding the structure-to-activity relationship of the quaternary benzophenanthridine alkaloids. The antiinflammatory potential and the cytotoxic effect are driven by the presence of a methylenedioxy ring attached at C7-C8 and C2-C3, respectively.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

The capability of minor quaternary benzophenanthridine alkaloids to inhibit TNF-α secretion and cyclooxygenase activity

et al. 2017

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“…Sanguinarine is well known to possess a broad range of biological functions, such as antimicrobial, antifungal, anti-inflammatory, and antineoplastic activities [19][20][21] . Sanguinarine-induced apoptosis has been detected in human epidermoid carcinoma (A431) [8] , human prostate cancer (LNCaP, DU-145, PC-3) [22,23] , and breast cancer (MCF-7) cell lines [7] , human endocervical (HeLa) [24] , human melanoma (M4Beu), human colon adenocarcinoma (DLD-1), lung non-small cell carcinoma (A549) [7] , human uveal melanoma (OCM-1) [25] , histiocytic lymphoma (U937), myeloid leukemia (ML-1a) [6] , human erythroleukemia (K562, JM1) cell lines [6,[26][27][28] , immortalized human keratinocytes (HaCaT) [26] and human primary fibroblasts [7,26] .…”

Section: Discussionmentioning

confidence: 99%

Apoptotic Effects of Sanguinarine on the Organ of Corti 1 Cells: Comparison with Cisplatin

Çeçen¹,

Erçetin²,

Kırkım³

et al. 2015

Int Adv Otol

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OBJECTIVE:Sanguinarine is an alkaloid obtained from the root of Sanguinaria canadensis and other plants from the Papaveraceae family and is well known to possess a broad range of biological functions, such as antimicrobial, antifungal, anti-inflammatory, and antineoplastic activities. We aimed to specify the in vitro effect of sanguinarine on the House Ear Institute-Organ of Corti 1 (HEI-OC1) cells and to compare this effect with the ototoxic effect of cisplatin (CDDP). MATERIALS and METHODS:We performed cell proliferation assay for determining the in vitro effect of sanguinarine alone and compared it with the effect of cisplatin. Flow cytometry annexin-V apoptosis detection was performed. RESULTS:We found that sanguinarine and CDDP inhibited the cell growth in a dose-dependant manner in HEI-OC1 cells after 24 h of incubation. In sanguinarine-treated group, apoptosis was 6.6%, necrosis was 26.7%, and the cell viability was 66.7%. Further, in CDDP-treated group, apoptosis was 5.6%, necrosis was 45.4%, and the cell viability was 48.7%. According to the annexin-V apoptosis detection results, we found that sanguinarine caused 3.9% apoptosis and 1.3% necrosis, while CDDP caused 2.9% apoptosis and 20% necrosis on HEI-OC1 cells. CONCLUSION:Our findings suggested that lower doses of sanguinarine are promising antineoplastic agents, which did not indicate any toxic effect on HEI-OC1 cells. Application of these data to clinical practice requires further support by in vivo studies.

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“…It is used as a naturopathic therapy for treating infections and managing pain, and as an expectorant, sedative and emetic (3). Sanguinarine has been demonstrated to exhibit anti-oxidant, anti-tumor, anti-inflammatory and anti-microbial properties (1,(4)(5)(6)(7). However, the effect of sanguinarine on neuroprotection has not been widely investigated.…”

Section: Introductionmentioning

confidence: 99%

“…Sanguinarine, with a formula of 13-methyl- [1,3]benzodiox olo [5,6-c]-1,3-dioxolo [4,5-i]phenanthridinium, is an active ingredient derived from the roots of Sanguinaria canadensis, the seeds of Argemone mexicana and from various other poppy-fumaria species (1,2). Sanguinarine is of great interest from a practical and research perspective due to its widespread and evident biological activities (3).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and neuroprotective effects of sanguinarine following cerebral ischemia in rats

Wang

Dai

Bao

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Stroke is one of the leading causes of mortality worldwide. Protective agents that can diminish injuries caused by cerebral ischemia-reperfusion (I/R) are important in alleviating the harmful outcomes of stroke. The aim of the present study was to investigate the protective role of sanguinarine in cerebral I/R injury. A rat middle cerebral artery occlusion model was used to assess the clinical effect of sanguinarine, and inflammatory cytokines in the serum were detected by ELISA. Western blotting was performed to examine the change in levels of apoptosis-associated proteins in the injured brains. The results suggested that sanguinarine, an anti-inflammatory agent derived from the roots of Sanguinaria canadensis, improved the state of cerebral ischemia in a rat model. The data demonstrated that when rats were treated with sanguinarine prior to middle cerebral artery occlusion, the infarct volume was reduced significantly. The inflammatory factors tumor necrosis factor-α, interleukin (IL)-6 and IL-1β were measured in sanguinarine and vehicle-treated groups using an enzyme-linked immunosorbent assay, and the expression levels of the three factors were significantly reduced following treatment with sanguinarine (P<0.05). In addition, western blot analysis demonstrated that the ratio of B-cell lymphoma 2/Bcl-2-associated X protein was significantly increased following treatment with sanguinarine (P<0.05). The study demonstrated that sanguinarine exerts a protective effect in cerebral ischemia, and that this effect is associated with the anti-inflammatory and anti-apoptotic properties of sanguinarine.

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The anti-inflammatory effects of sanguinarine and its modulation of inflammatory mediators from peritoneal macrophages

Cited by 100 publications

References 45 publications

The capability of minor quaternary benzophenanthridine alkaloids to inhibit TNF-α secretion and cyclooxygenase activity

The capability of minor quaternary benzophenanthridine alkaloids to inhibit TNF-α secretion and cyclooxygenase activity

Apoptotic Effects of Sanguinarine on the Organ of Corti 1 Cells: Comparison with Cisplatin

Anti-inflammatory and neuroprotective effects of sanguinarine following cerebral ischemia in rats

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