The anti-inflammatory effects of dry-cured ham derived peptides in RAW264.7 macrophage cells

A Yeast-Derived Peptide Promotes Skin Wound Healing by Stimulating Effects on Fibroblast and Immunomodulatory Activities

“…Inhibition of NO/iNOS and PGE2/COX-2 pathways has been reported for peptide PAY obtained from salmon protein hydrolysate [26,34]. Regulation of the STAT1/IRF3 signaling pathway has been reported for the anti-inflammatory activity of Bee venom [35] and regulation of PI3K/AKT was reported to be involved in anti-inflammatory activity of Xuanwei ham derived peptides in LPS-stimulated macrophages [5]. Additionally, destabilization of cytokine mRNA and action on post-transcriptional steps may be responsible for the final suppression of mRNA to protein translation [36].…”

“…Antioxidant, anti-inflammatory, antimicrobial activity, as well as their ability to improve cell adhesion, and modulate immune responses, are among the properties that make peptides suitable for functionalization of biomaterials and wound healing applications [3,4]. Although it is well-established that the biological activities of peptides depend on their molecular weight and amino acid sequences, the link between the structure and function is not fully understood [5]. Small peptides below 1 KDa derived from different sources such as IPP and VPP from fermented milk [5], IRW and IQW from egg protein [6,7], PLV and VPY from soy protein [8,9], PTGADY from Alaska pollock protein [10], and PAY from salmon protein [11] can be absorbed by immune and skin cells and modulate cell functions [12].…”

“…Although it is well-established that the biological activities of peptides depend on their molecular weight and amino acid sequences, the link between the structure and function is not fully understood [5]. Small peptides below 1 KDa derived from different sources such as IPP and VPP from fermented milk [5], IRW and IQW from egg protein [6,7], PLV and VPY from soy protein [8,9], PTGADY from Alaska pollock protein [10], and PAY from salmon protein [11] can be absorbed by immune and skin cells and modulate cell functions [12]. In these peptides, hydrophobic amino acids are the key players in their anti-inflammatory activity and proliferative properties on fibroblasts.…”

The Anti-Inflammatory Effect of Bovine Bone-Gelatin-Derived Peptides in LPS-Induced RAW264.7 Macrophages Cells and Dextran Sulfate Sodium-Induced C57BL/6 Mice

“…The 0.5 mg/mL of GP group showed no differences in IL-1β expression compared with PC ( p > 0.05), whereas the 1.0 mg/mL of GP group was investigated to exert the suppressing effect on IL-1β ( Figure 2 E, p < 0.05). Regarded as the potential resource of anti-inflammatory components, the dry-cured ham peptides were also checked to repress the proinflammatory mediators of TNF-α, IL-6, IL-8, and IL-1β in the LPS-induced RAW264.7 macrophage cells, where the isolated sequences of GPPGL, GPAGPL, and GPPGAP were all originated from collagen protein [ 20 ]. Derived from dynastid beetle, the bioactive peptides inhibited the cyclooxygenase-2 (COX-2), iNOS, IL-6, and IL-1β expression [ 21 ].…”

“…From the current results, the GP sequences were mainly composed by 7-15 amino acids and the GPP fragment appeared in 397 peptides such as FLPAGPPE, GRGPPLGF, GPPGFQGPK, GPPGFGPGY, GPPGEPGPQ, GPPGFPGLE, etc. Similarly, the anti-inflammatory peptides in dry-cured hams (GPPGL, GPPGAP) was also composed by GPP fragment, which means the certain sequences play an important role in inflammation function [ 20 ].…”