The anti-HBc IgM response in the acute and convalescent phases of acute hepatitis

Mortimer, Philip P.; Vandervelde, Elise M.; Parry, J. V.; Cohen, B. J.; Tedder, Richard S.

doi:10.1016/s0163-4453(81)91920-4

Cited by 22 publications

(10 citation statements)

References 5 publications

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“…In addition we have determined the time course of reactivity for IgM anti-HBc in acute hepatitis B infection. Preliminary results on reactivity of the MACRIA in acute hepatitis B infection have already been reported (Mortimer et al 1980). In order to confirm the specificity of this assay for IgM anti-HBc detection, some sera in this study were also assayed for IgM antibody by the method using gel-filtration for serum fractionation.…”

Section: Introductionmentioning

confidence: 70%

IgM-antibody response to the hepatitis B core antigen in acute and chronic hepatitis B

Tedder

Wilson-Croome

1981

J. Hyg.

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SUMMARYA solid phase M-antibody capture radioimmunoassay (MACRIA) and a serum fractionation method were used to quantitate the IgM response to the hepatitis B core antigen (IgM anti-HBc) in acute and chronic hepatitis B infections.Antibody to the core antigen was predominantly of the IgM class during the acute phase of hepatitis B. Resolving acute infections remained positive by MACRIA, but at decreasing levels, for as long as 6 months. IgM anti-HBc persisted in HBsAg carriers but at levels very much lower than seen in acute infections. There was no correlation of IgM anti-HBc with severity of chronic liver disease in carriers.Measurement of IgM anti-HBc by MACRIA enabled accurate identification of acute hepatitis B on single serum specimens.

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Section: Introductionmentioning

confidence: 70%

IgM-antibody response to the hepatitis B core antigen in acute and chronic hepatitis B

Tedder

Wilson-Croome

1981

J. Hyg.

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“…The IgM anti-HBc response has been reported to be transient (detectable for 3 to 6 months after the onset of symptoms) in contrast to IgG anti-HBc which may be detected indefinitely. [Mortimer et al, 1981;…”

Section: Abstract: Hepatitis a Hepatitis 6 Hbsagmentioning

confidence: 99%

Differential diagnosis of acute viral hepatitis using rapid, fully automated immunoassays

Eble

Clemens

Krenc

et al. 1991

Journal of Medical Virology

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We report the development of three rapid, fully automated immunoassays allowing the differential diagnosis of acute viral hepatitis. These assays detect HBsAg, IgM antibody to hepatitis B core antigen (IgM anti-HBc) and IgM antibody to hepatitis A virus (IgM anti-HAV) using the IMx instrument system. All IMx assays were run in less than 45 minutes and all steps were fully automated including specimen dilution steps. Specimens from blood donors, diagnostic and hospital patients, and individuals with a variety of infectious and immune diseases were tested for IgM anti-HAV (n = 1473) or for IgM anti-HBc (n = 1606) or for HBsAg (n = 9700) by the IMx and commercially available EIA and RIA. Each IMx assay showed 99.8% agreement with current EIA. Reproducibility in all hepatitis IMx assays was significantly better than that observed with manual or semiautomated assays; within-run and between-run % CV ranged from 2.2 to 4.8 and 3.5 to 10.3 respectively. In 29 acute hepatitis B patients studied, HBsAg and IgM anti-HBc were detected in the first available patient bleed collected from 0 to 4 week from the onset of symptoms. IgM anti-HBc persisted at reactive levels in the IMx assay for 1 to 24 weeks (mean 12.1 +/- 5.3 weeks) after the patient presented with symptoms. In individuals exposed to hepatitis A, IgM anti-HAV was detectable by IMx by 40 days post exposure (average 33.5 days) and IgM had declined to unreactive levels in IMx for all patients by from 3 to 6 months post exposure. These data demonstrate the use of these rapid IMx assays for differentiation of acute hepatitis A and B.

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“…In HBV infection, previous observations in patients with acute type B hepatitis have almost always shown the presence of anti-HBc IgM in high titers [Gerlich et al, 1980;Tedder et al, 1981;Mortimer et al, 1981;Lemon et al, 1981;Roggendorf et al, 1981;Kryger et al, 1981;Kryger et al, 1982;Chau et al, 19831. Thus absence of this IgM antibody in the acute stage of infection is believed very useful in ruling out acute HBV infections [Gitnick et al, 19831. However, this is not the case in infants born to HBsAg carrier mothers, as shown in our study.…”

Section: Discussionmentioning

confidence: 97%

“…Recently, sensitive and specific immunoassays for anti-HBc of the IgM class (anti-HBc IgM) have been shown to be extremely useful in diagnosing acute type B hepatitis [Gerlich et al, 1980;Tedder et al, 1981;Mortimer et al, 1981;Lemon et al, 1981;Roggendorf et al, 1981;Kryger et al, 1981;Kryger et al, 1982;Chau et al, 19831. With very few exceptions, anti-HBc IgM is present uniformly in patients with acute hepatitis B.…”

Section: Introductionmentioning

confidence: 99%

Inadequacy of lmmunoglobulin M hepatitis B core antibody in detecting acute hepatitis B virus infection in infants of HBsAg carrier mothers

Chen

Sung

Lai

et al. 1985

Journal of Medical Virology

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To study the usefulness of IgM hepatitis B core antibody (anti-HBc IgM) for detecting hepatitis B virus infections in infants of hepatitis B surface antigen (HBsAg) carrier mothers, serial serum samples from 86 infants of carrier mothers were tested for anti-HBc IgM with a highly specific enzyme immunoassay. Asymptomatic hepatitis B infection occurred frequently in infants under 12 mo of age. Anti-HBc IgM never became positive in 25 infants infected under 9 mo old. It was positive in only 1 of 6 infected at 9 mo and 4 of 13 infected at 12 mo of age. The IgM antibody lasted for less than 6 mo. Although the infection was delayed in 28 infants receiving hepatitis B immune globulin, the poor anti-HBc IgM response did not seem to be due to the immune prophylaxis. Our study clearly indicates the limitation of anti-HBc IgM for detecting acute hepatitis B infection in infants born to HBsAg carrier mothers.

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The anti-HBc IgM response in the acute and convalescent phases of acute hepatitis

Cited by 22 publications

References 5 publications

IgM-antibody response to the hepatitis B core antigen in acute and chronic hepatitis B

IgM-antibody response to the hepatitis B core antigen in acute and chronic hepatitis B

Differential diagnosis of acute viral hepatitis using rapid, fully automated immunoassays

Inadequacy of lmmunoglobulin M hepatitis B core antibody in detecting acute hepatitis B virus infection in infants of HBsAg carrier mothers

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