The Anti-Cancer Activity of Noscapine: A Review

Mahmoudian, Massoud; Rahimi‐Moghaddam, Parvaneh

doi:10.2174/157489209787002524

Cited by 129 publications

(88 citation statements)

References 27 publications

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“…Current studies show that alkaloids obtained from Papaver species could not only be used as analgesic or sedative but also in other areas such as cancer treatment [12]. P. somniferum L. alkaloids that show promise in cancer treatment include noscapine, which interacts with α-tubulin and has anticancer and antiangiogenetic properties [13,14]; codeinone, an oxidative product of codeine which has apoptotic effects through fragmentation of DNA [15]; morphine, which shows anticancer activities by inhibiting NF-κB; and (-)-3-acetyl-6β-(acetylthio)-N-(cyclopropyl-methyl)-normorphine (KT-90), a derivative of morphine [16]. To the best of our knowledge, pharmacological effects of P. somniferum L. extracts on HT29, HeLa, C6 cancer cell lines and Vero normal cell lines have not been investigated in detail.…”

Section: Introductionmentioning

confidence: 99%

Anticancer Activity of Papaver Somniferum

Güler¹,

Aydın²,

Koyuncu³

et al. 2016

J. Turk. Chem. Soc., Sect. A: Chem.

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Abstract:This work describes the pharmacological activity of extracts of Papaver somniferum L., a poppy species. P. somniferum L. products are still considered as a unique source of drug for many diseases. The present study was designed to determine antiproliferative and cytotoxic effects of P. somniferum L. extracts on HeLa (Human Cervix Carcinoma), HT29 (Human Colorectal Adenocarcinoma), C6 (Rat Brain Tumor Cells), and Vero (African Green Monkey Kidney) cell lines. Alkaloid-rich extracts of P. somniferum L. exhibited antiproliferative effects on various cancer cell lines, especially at high concentrations. We assessed the ability of extracts of P. somniferum L. to give harm to the membrane of the cells. Results indicated that P. somniferum L. extracts destroy cellular membrane in tumor cell lines at high concentrations. Remarkably, the LDH test results disclosed that cytotoxicity of P. somniferum L. on cells was low at middle concentrations. This may indicate its cytostatic potential. The results of this study support the efficacy of P. somniferum L. extracts as an anticancer agent.

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Section: Introductionmentioning

confidence: 99%

Anticancer Activity of Papaver Somniferum

Güler¹,

Aydın²,

Koyuncu³

et al. 2016

J. Turk. Chem. Soc., Sect. A: Chem.

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“…1), a nonaddictive phthalideisoquinoline alkaloid obtained from opium poppy latex, has been broadly recognized as a safe and promising oral antitussive agent . Recently, noscapine has shown antiproliferative activity against a wide variety of tumor cell types (Mahmoudian and Rahimi-Moghaddam, 2009). Pretreatment with oral noscapine was also proven to limit lymphatic metastasis of human prostate cancer PC3 cells in nude mouse models (Barken et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Characterization of Inhibition Kinetics of (S)-Warfarin Hydroxylation by Noscapine: Implications in Warfarin Therapy

et al. 2013

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Noscapine is an antitussive and potential anticancer drug. Clinically significant interactions between warfarin and noscapine have been previously reported. In this study, to provide a basis for warfarin dosage adjustment, the inhibition kinetics of noscapine against warfarin metabolism was characterized. Our enzyme kinetics data obtained from human liver microsomes and recombinant CYP2C9 proteins indicate that noscapine is a competitive inhibitor of the (S)-warfarin 7-hydroxylation reaction by CYP2C9. Interestingly, noscapine also inhibited (S)-warfarin metabolism in a NADPHand time-dependent manner, and removal of unbound noscapine and its metabolites by ultrafiltration did not reverse inhibition of (S)-warfarin metabolism by noscapine, suggesting mechanism-based inhibition of CYP2C9 by noscapine. Spectral scanning of the reaction between CYP2C9 and noscapine revealed the formation of an absorption spectrum at 458 nm, indicating the formation of a metabolite-intermediate complex. Surprisingly, noscapine is a 2-to 3-fold more efficient inactivator of CYP2C9.2 and CYP2C9.3 variants than it is of the wild type, by unknown mechanisms. Based on the inhibitory kinetic data, (S)-warfarin exposure is predicted to increase up to 7-fold (depending on CYP2C9 genotypes) upon noscapine coadministration, mainly due to mechanism-based inactivation of CYP2C9 by noscapine. Together, these results indicate that mechanism-based inhibition of CYP2C9 by noscapine may dramatically alter pharmacokinetics of warfarin and provide a basis for warfarin dosage adjustment when noscapine is coadministered.

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“…15 These agents possess properties such as anti-inflammatory activities in addition to anti-proliferative function. Colchicine and vinblastine have been shown to down-regulate TNFα secretion in macrophages.…”

Section: -11mentioning

confidence: 99%

A Tubulin Inhibitor, N-(5-Benzyl-1,3-thiazol-2-yl)-3-(furan-2-yl)prop-2-enamide, Induces Anti-inflammatory Innate Immune Responses to Attenuate LPS-mediated Septic Shock

Park

Lee

Park

et al. 2014

Bulletin of the Korean Chemical Society

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The anti-inflammatory effect of a tubulin inhibitor, N-(5-benzyl-1,3-thiazol-2-yl)-3-(furan-2-yl)prop-2-enamide (1), on innate immune responses remains unclear. Thus, we investigated the effect of 1 on the immune responses mediated by lipopolysaccharide (LPS). The in vitro addition of 1 to dendritic cells and macrophages dose-dependently reduced tumor necrosis factor alpha production elicited by LPS stimulation. Additionally, the stimulation of natural killer (NK) and natural killer T (NKT) cells with 1 resulted in the decrease of interferon gamma (IFNγ) induced by LPS treatment. Moreover, 1 substantially reduced interleukin 12 in dendritic cells (DC) as well as IFNγ in NKDCs induced by LPS in vitro. Furthermore, the in vivo administration of 1 ameliorated LPS/D-galactosamine-induced endotoxic lethality in mice. Taken together, our results demonstrate for the first time that 1 possesses anti-inflammatory properties, most notably by modulating LPSinduced innate immune responses. Therefore, 1 might have therapeutic potential for the treatment of inflammation-mediated diseases such as sepsis.

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The Anti-Cancer Activity of Noscapine: A Review

Cited by 129 publications

References 27 publications

Anticancer Activity of Papaver Somniferum

Anticancer Activity of Papaver Somniferum

Characterization of Inhibition Kinetics of (S)-Warfarin Hydroxylation by Noscapine: Implications in Warfarin Therapy

A Tubulin Inhibitor, N-(5-Benzyl-1,3-thiazol-2-yl)-3-(furan-2-yl)prop-2-enamide, Induces Anti-inflammatory Innate Immune Responses to Attenuate LPS-mediated Septic Shock

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