Anticancer Activity of Papaver Somniferum

Abstract

Abstract:This work describes the pharmacological activity of extracts of Papaver somniferum L., a poppy species. P. somniferum L. products are still considered as a unique source of drug for many diseases. The present study was designed to determine antiproliferative and cytotoxic effects of P. somniferum L. extracts on HeLa (Human Cervix Carcinoma), HT29 (Human Colorectal Adenocarcinoma), C6 (Rat Brain Tumor Cells), and Vero (African Green Monkey Kidney) cell lines. Alkaloid-rich extracts of P. somniferum L. exhibited antiproliferative effects on various cancer cell lines, especially at high concentrations. We assessed the ability of extracts of P. somniferum L. to give harm to the membrane of the cells. Results indicated that P. somniferum L. extracts destroy cellular membrane in tumor cell lines at high concentrations. Remarkably, the LDH test results disclosed that cytotoxicity of P. somniferum L. on cells was low at middle concentrations. This may indicate its cytostatic potential. The results of this study support the efficacy of P. somniferum L. extracts as an anticancer agent.

Papaver decaisnei: GC-MS alkaloids profiling, in vitro antioxidant, and anticancer activity

“…The effectivity of roemerine to reduce the proliferation and migration of different human cell lines and stimulated their apoptosis in different degrees have also reported previously [11]. Similar to our ndings, researches have also reported the superiority of P.somniferum roots against HeLa cell lines [12]. Moreover, it could be emphasized that Papaveraceae members are rich with alkaloid contents and many studies have shown their anticancer e cacy against several human cancer cell lines [52], [53].…”

Ligand-based virtual screening and molecular docking of two cytotoxic compounds isolated from Papaver lacerum

“…Previous studies using brine shrimp assays revealed that methanolic extracts of P. pavoninum and P. dubium exhibited a cytotoxic effect (Ibrar et al, 2015;Mat et al, 2000). Furthermore, the P. somniferum extract showed strong anti-proliferative activity against the HeLa and HT29 cell lines (Güler et al, 2016) whereas P. rhoeas had an anticancer effect on the MCF7 and HCT116 cell lines (Hijazi et al, 2017). In this study, five Papaver species were collected and screened to determine their anticancer activity on the HeLa cell line.…”

Papaver Decaisnei: GC-MS Alkaloids Profiling, in Vitro Antioxidant, and Anticancer Activity

“…This biological activity by Papaver species has been linked with its moderate hydrophilic secondary metabolites such as phenolic acids, avonoids, and its glycosides, as well as compounds soluble in lipid fractions like sterols, tocopherols, tocotrienols, carotenoids and zeaxanthins, which may act as antioxidant agents in diseases related with oxidative stress [9], [10]. Alkaloid chemicals (macranthine, berberine, roemerin, and Noscapine) of Papaver species acquired more attention as anticancer agents in recent years [11], [12], [13]. Enlightened by the above passage, identifying the biologically active chemicals in the Papaver species and Papaver organs aids breeders to select desired poppy genotypes for the purpose of harvesting and breeding process, which could help in developing functional foods with better health bene ts for the consumers.…”