The anthelmintic efficacy of the plant, Albizia anthelmintica, against the nematode parasites Haemonchus contortus of sheep and Heligmosomoides polygyrus of mice

Githiori, J. B.; Höglund, Johan; Waller, P.J.; Baker, R. L.

doi:10.1016/s0304-4017(03)00218-8

Cited by 54 publications

(30 citation statements)

References 17 publications

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“…The majority of ethnoveterinary reports originate from ruminants, as the main livestock species that generate income in poor countries (IIRR, 1994). Consequently, when the antiparasitic activity of such plants is tested in rodent models, for example in the form of dried plant, part of the reported variation may be due to the physiological difference between ruminant and nonruminant animals (Satrija et al, 1994;Ignacio et al, 2001;Githiori et al, 2003a and. Other methodological limitations include the great variation observed in the protocols of collection and storage of the plant material prior to its use, if not grazed or consumed immediately.…”

Section: Studies On the Whole Plant: Strengths And Limitationsmentioning

confidence: 99%

“…Despite the abundant evidence on the potential negative effects of plant active metabolites in herbivores, to date the majority of the studies investigating the anthelmintic activity of medicinal plants is lacking measurements on the potential negative effects on the host. A small number of studies have monitored host's performance (Athanasiadou et al, 2000 and2001a;Butter et al, 2001;Githiori et al, 2004), and have reported clinical toxicity (Akhtar and Ahmad, 1992;Satrija et al, 1994;Dawson et al, 1999;Githiori et al, 2003a), which escalate as the concentrations of active compounds increase. In extreme cases, even the death of animals under treatment has been reported (Athanasiadou et al, 2001a;Githiori et al, 2003a).…”

Section: Medicinal Plants and Parasitised Hosts: Viewing The Whole Pimentioning

confidence: 99%

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Medicinal plants for helminth parasite control: facts and fiction

Athanasiadou

Githiori

Kyriazakis

2007

Animal

198

129

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The use of medicinal plants for the prevention and treatment of gastro-intestinal parasitism has its origin in ethnoveterinary medicine. Although until recently the majority of the evidence on the antiparasitic activity of medicinal plants was anecdotal and lacked scientific validity, there is currently an increasing number of controlled experimental studies that aim to verify and quantify such plant activity. There are indeed a large number of plants whose anthelmintic activity has been demonstrated under controlled experimentation, either through feeding the whole plant or administering plant extracts to parasitised hosts. However, contrary to traditional expectation, there are also a great number of plants with purported antiparasitic properties, which have not been reproduced under experimental conditions. In this paper, we discuss the source of such inconsistencies between ethnoveterinary wisdom and scientific experimentation. We focus on the strengths and weaknesses of the existing methodologies used in the controlled studies to determine the activity of antiparasitic plants. We discuss issues like the seasonal and environmental variability of the plant composition, and how this can affect their antiparasitic properties and highlight the importance of identifying the mechanisms of action of such plants and the target parasite species. In addition to their antiparasitic properties, medicinal plants may also have anti-nutritional properties, which can affect animal performance and behaviour. For this reason, we emphasise the need for considering additional dimensions when evaluating medicinal plants. We also question whether using similar criteria as those used for the evaluation of anthelmintics is the way forward. We propose that a holistic approach is required to evaluate the potential of medicinal plants in parasite control and maximise their benefits on parasitised hosts. Keywords: bioactive plants, ethnoveterinary medicine, medicinal plants, parasites, ruminants IntroductionFor centuries, medicinal plants have been used to combat parasitism, and in many parts of the world are still used for this purpose. In ethnoveterinary medicine, which draws inspiration from traditional practice, there seems to be a range of plant/s or plant extract suitable for treating almost every parasitic disease of livestock (International Institute of Rural Reconstruction (IIRR), 1994). For example, seeds of garlic, onion and mint have been used to treat animals that suffer from gastro-intestinal parasitism, whereas extracts of the tobacco plant have been used to treat the skin of livestock afflicted with external parasites (Guarrera, 1999). Leaves, dried flowers and oil from Chenopodium ambrosioides, a shrub that originated from Central America and has been distributed around the world, have all been used as anthelmintics since the early 1900s (Guarrera, 1999).Reports from around the world include exhaustive lists of plants that have been reported to have medicinal properties (Hammond et al., 1997;Akhtar et al., 2000;Waller ...

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Section: Studies On the Whole Plant: Strengths And Limitationsmentioning

confidence: 99%

Section: Medicinal Plants and Parasitised Hosts: Viewing The Whole Pimentioning

confidence: 99%

Medicinal plants for helminth parasite control: facts and fiction

Athanasiadou

Githiori

Kyriazakis

2007

Animal

198

129

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“…Piperazine salts are among the most extensively used anthelmintics in livestock production, because, they are cheap and effective. However, there are increasing reports of development of resistance by helminth parasites against piperazine and other anthelmintics [2][3][4]. This calls for research for drugs to combine with piperazine salts for treatment of helminthosis, to improve their efficacy, for better perfomance of livestock and to reduce rate of development of anthelmintic resistance.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of piperzine citrate, stabilized with Aluminium-Magnesium Silicate, against <i>Helignosomoides bakeri</i>

Ezeibe¹,

Dire²,

Anosa³

et al. 2012

Health

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“…It is generally considered that the anthelminthic effects of forage containing tannins are related to their content of condensed tannins (Hoste et al, 2011). Some in vitro results suggest also that secondary metabolites such as flavonoid and alkaloïds (Molan et al, 2003;;Barrau et al, 2005;Brunet and Hoste, 2006;Eguale et al, 2008;Chagas et al, 2008;Muthee et al, 2011), saponins (Ademola and Eloff, 2010;Waterman et al, 2010) and terpenoids (Marley et al, 2006;Githiori et al, 2003) may possess some anthelminthic properties. The dosedependent relationship between the concentration of tannins and/or flavonoid compounds and the anthelminthic activity has been demonstrated under both in vitro (Molan et al, 2002;Brunet and Hoste, 2006) and in vivo conditions (Hoste et al, 2011;Brunet et al, 2007;Terrill et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Phytochemical analysis and ovicidal activity of Cassia sieberiana, Guiera senegalensis and Excoecaria grahamii extracts

Traore¹,

Ouédraogo²,

Belemlilga³

et al. 2017

Afr. J. Pharm. Pharmacol.

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The anthelmintic efficacy of the plant, Albizia anthelmintica, against the nematode parasites Haemonchus contortus of sheep and Heligmosomoides polygyrus of mice

Cited by 54 publications

References 17 publications

Medicinal plants for helminth parasite control: facts and fiction

Medicinal plants for helminth parasite control: facts and fiction

Efficacy of piperzine citrate, stabilized with Aluminium-Magnesium Silicate, against <i>Helignosomoides bakeri</i>

Phytochemical analysis and ovicidal activity of Cassia sieberiana, Guiera senegalensis and Excoecaria grahamii extracts

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The anthelmintic efficacy of the plant, Albizia anthelmintica, against the nematode parasites Haemonchus contortus of sheep and Heligmosomoides polygyrus of mice

Cited by 54 publications

References 17 publications

Medicinal plants for helminth parasite control: facts and fiction

Medicinal plants for helminth parasite control: facts and fiction

Efficacy of piperzine citrate, stabilized with Aluminium-Magnesium Silicate, against &lt;i&gt;Helignosomoides bakeri&lt;/i&gt;

Phytochemical analysis and ovicidal activity of Cassia sieberiana, Guiera senegalensis and Excoecaria grahamii extracts

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Efficacy of piperzine citrate, stabilized with Aluminium-Magnesium Silicate, against <i>Helignosomoides bakeri</i>