Phytochemical analysis and ovicidal activity of Cassia sieberiana, Guiera senegalensis and Excoecaria grahamii extracts

Traore, Aristide; Ouédraogo, Sylvin; Belemlilga, Mohamed Bonewendé; Kaboré, Adama; Guissou, Innocent Pierre

doi:10.5897/ajpp2017.4837

Cited by 7 publications

(2 citation statements)

References 36 publications

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“…This activity would be due to the chemical compounds contained in the plant. Indeed, several studies have shown that extracts of Guiera senegalensis contain mainly flavonoids, tannins, saponins, coumarins, alkaloids [30,31]. It appears clearly that these four medicinal plants of this recipe «Actiplus» are rich in active phytochemical compounds both quantitatively and qualitatively, which justifies the therapeutic effects of these plants and thus of the recipe «Acti-plus».…”

Section: Discussionmentioning

confidence: 89%

Cytotoxic Properties on Prostate and Cervical Cancer Cells in Culture of «Acti-plus», a Recipe Based on Medicinal Plants from Burkina Faso

Donald Wilfried Adico,

Bayala,

Valérie Elvira Jean Télesphore Bazié

et al. 2023

JDMP

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Medicinal plants are increasingly emerging as a real alternative that can contribute to the fight against cancer. The purpose of this study was to evaluate in vitro the antiradical, anti-lipoxygenase and cytotoxic properties on cancerous cells in culture of the medicinal recipe «Acti-plus». The extraction of «Acti-plus» was carried out according the instructions of the traditional health practitioner. Phytochemical screening, as well as the determination of polyphenols and total flavonoids were performed using characterization and assay tests by spectrometry as well as by high performance thin layer chromatography (HPTLC). Antiradical tests for trapping DPPH and ABTS radicals were used to measure the antioxidant potential. Antilipoxygenase activity was studied using 15-lipoxygenase (15-LOX) inhibition test. The cytotoxic activity of aqueous extract of «Acti-plus» was evaluated in vitro on human cancers cell using MTT test. The results of the study showed that aqueous extract of «Acti-plus» contains flavonoids, coumarins and tannins. Total phenolic compounds (TPC) and total flavonoids (TFC) were 61.95 ± 0.01 mg GAE/g dry extract and 43.01 ± 0.05 mg QE/g dry extract respectively. The extract exhibited excellent scavenging capacity of DPPH (IC 50 = 9.33 ± 1.53 µg/mL) and ABTS (IC 50 = 53.33 ± 0.89 µg/mL) radicals antioxidant potential. The study also found that the extract moderately inhibits 15-lipoxygenase at 100 µg/mL. Aqueous extract of «Actiplus» inhibited in a concentration-dependent manner the proliferation of the three cell lines with best activity (IC 50 = 0.317 ± 0.02 mg/mL) on prostate cancer PC-3 cells. These properties give a rational basis for the use of the recipe «Acti-plus» in traditional medicine in Burkina Faso.

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Section: Discussionmentioning

confidence: 89%

Cytotoxic Properties on Prostate and Cervical Cancer Cells in Culture of «Acti-plus», a Recipe Based on Medicinal Plants from Burkina Faso

Donald Wilfried Adico,

Bayala,

Valérie Elvira Jean Télesphore Bazié

et al. 2023

JDMP

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“…In Burkina Faso, some researchers have already shown interest in plants with anthelmintic properties for veterinary use that could be an alternative to synthetic anthelmintics. These include: Balanites aegyptiaca [17], Saba senegalensis [18], Cassia sieberiana, Guiera senegalensis and Excoecaria grahamii [19], Securidaca longepedunculata [20]. For more efficiency in improving the health of small ruminants, it would be wise to conduct studies on forage plants for their nutritional values and also for their richness in specific secondary metabolites such as tannins, flavonoids, saponins and alkaloids, whose anthelmintic properties and effects on zootechnical performance are known [21] [22] [23].…”

Section: Introductionmentioning

confidence: 99%

Acute Toxicity and Anthelmintic Effects of Gomphrena serrata L. (Amaranthaceae) Extracts on Adult Worms and Eggs of Haemonchus contortus

Ouedraogo,

Belemlilga,

Traore

et al. 2024

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Gomphrena serrata L. (Amaranthaceae) is a medicinal plant widely used traditionally in rural areas to treat many diseases, including gastrointestinal helminthiasis of small ruminants. This work aims to estimate the plant extracts phytochemical potential and study the activities of the aqueous decoction (GS_AD), aqueous macerate (GS_AM), and hydroalcoholic macerate (GS_HEM) of Gomphrena serrata extracts on two developmental stages (eggs and adult worms) of Haemonchus contortus. Phytochemical screening was carried out. The acute toxicity test was performed according to the Organisation for Economic Co-operation and Development (OECD) test guideline 423. The Haemonchus contortus eggs hatching inhibition test was performed left to incubate for 48 hours in the presence of the different plant extracts at increasing concentrations of 0.125; 0.25; 0.5; 0.625; 1; 2; 3 mg/mL. For the motility inhibition test on adult worms, the worms were contacted with the extracts at concentrations of 0.75; 1; 1.25; 1.5; 2; 3; 4 mg/mL and left to incubate for 24 hours. Albendazole and levamisole were used as standard. Phytochemical screening revealed the presence of tannins, saponins, reducing compounds, coumarins and derivatives, anthocyanins, steroids, triterpenes, and flavonoids. An acute toxicity study showed that the oral LD 50 value of G.

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In vitro and in vivo anthelmintic effects of Sterospermum kunthianum (Cham-Holl) leaf extract against Ascaridia galli in experimentally infected broiler chickens

et al. 2021

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Phytochemical analysis and ovicidal activity of Cassia sieberiana, Guiera senegalensis and Excoecaria grahamii extracts

Cited by 7 publications

References 36 publications

Cytotoxic Properties on Prostate and Cervical Cancer Cells in Culture of «<i>Acti-plus</i>», a Recipe Based on Medicinal Plants from Burkina Faso

Cytotoxic Properties on Prostate and Cervical Cancer Cells in Culture of «<i>Acti-plus</i>», a Recipe Based on Medicinal Plants from Burkina Faso

Acute Toxicity and Anthelmintic Effects of <i>Gomphrena </i><i>serrata</i> L. (Amaranthaceae) Extracts on Adult Worms and Eggs of <i>Haemonchus </i><i>c</i><i>ontortus</i>

In vitro and in vivo anthelmintic effects of Sterospermum kunthianum (Cham-Holl) leaf extract against Ascaridia galli in experimentally infected broiler chickens

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Phytochemical analysis and ovicidal activity of Cassia sieberiana, Guiera senegalensis and Excoecaria grahamii extracts

Cited by 7 publications

References 36 publications

Cytotoxic Properties on Prostate and Cervical Cancer Cells in Culture of «&lt;i&gt;Acti-plus&lt;/i&gt;», a Recipe Based on Medicinal Plants from Burkina Faso

Cytotoxic Properties on Prostate and Cervical Cancer Cells in Culture of «&lt;i&gt;Acti-plus&lt;/i&gt;», a Recipe Based on Medicinal Plants from Burkina Faso

Acute Toxicity and Anthelmintic Effects of &lt;i&gt;Gomphrena &lt;/i&gt;&lt;i&gt;serrata&lt;/i&gt; L. (Amaranthaceae) Extracts on Adult Worms and Eggs of &lt;i&gt;Haemonchus &lt;/i&gt;&lt;i&gt;c&lt;/i&gt;&lt;i&gt;ontortus&lt;/i&gt;

In vitro and in vivo anthelmintic effects of Sterospermum kunthianum (Cham-Holl) leaf extract against Ascaridia galli in experimentally infected broiler chickens

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Cytotoxic Properties on Prostate and Cervical Cancer Cells in Culture of «<i>Acti-plus</i>», a Recipe Based on Medicinal Plants from Burkina Faso

Cytotoxic Properties on Prostate and Cervical Cancer Cells in Culture of «<i>Acti-plus</i>», a Recipe Based on Medicinal Plants from Burkina Faso

Acute Toxicity and Anthelmintic Effects of <i>Gomphrena </i><i>serrata</i> L. (Amaranthaceae) Extracts on Adult Worms and Eggs of <i>Haemonchus </i><i>c</i><i>ontortus</i>