The Angiotensin-Infusion Test

Kaplan, Norman M.; Silah, Jack G.

doi:10.1056/nejm196409102711103

Cited by 121 publications

(9 citation statements)

References 13 publications

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“…Stimulation of the renin-releasing mechanisms seems to be more effective in patients with renovascular hypertension than in those with essential hypertension (Weidmann et al, 1967a) or in normal subjects (Cohen et al, 1966;Kaneko et al, 1967). Kaplan and Silah (1964) introduced the angiotensin infusiom test as a simple screening procedure in the evaluation of hypertensives. The usefulness of this test has been confirmed by Hocken et al (1966).…”

Section: Intoductionmentioning

confidence: 99%

Plasma Renin Activity and Angiotensin Pressor Dose in Hypertension: Correlation and Diagnostic Implications

Weidmann¹,

Endres²,

Siegenthaler³

1968

BMJ

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IntoductionExtensive experimental and clinical studies during recent years have shown the importance of the renin-angiotensinaldosterone system in the regulation of sodium and water balance. There is, however, still some controversy about the significance of these substances in the pathogenesis of hypertension. The fact that markedly raised secretion of renin, angiotensin, and aldosterone may be associated with normal or even reduced blood pressure has been a perpetual source of doubt in this connexion (Gross et al., 1964 ;Brown et al., 1967).The elaboration of methods of assessing these three substances has facilitated the diagnosis of certain forms of hypertension. The combination of high blood pressure, low renin, and elevated aldosterone suggests Conn's syndrome Brown et al., 1965;Weidmann et al., 1967b). Stimulation of the renin-releasing mechanisms seems to be more effective in patients with renovascular hypertension than in those with essential hypertension (Weidmann et al., 1967a) (Breckenridge, 1965 ;Fitz et al., 1965)

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Section: Intoductionmentioning

confidence: 99%

Plasma Renin Activity and Angiotensin Pressor Dose in Hypertension: Correlation and Diagnostic Implications

Weidmann¹,

Endres²,

Siegenthaler³

1968

BMJ

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“…An alternative explanation for this resistance is that the high plasma renin activity of pregnancy produces elevated endo genous angiotensin II levels which saturate the receptor sites. K aplan and S il a h [4] suggested these factors were a cause o f resistance to angiotensin infusion in certain patients other than those with reno vascular hypertension.…”

Section: Discussionmentioning

confidence: 99%

“…Ch e sl e y etal. [2] found that pregnant women had a blunted response to angiotensin II infusion, possibly related to elev ated endogenous levels of A ll [4], Furthermore, although pregnant and non-pregnant women respond to cquipressor infusions of angio tensin II with a fall in sodium excredon, the response in the pregnant group has been shown to be significantly less than the non-pregnant group [1].…”

Section: Introductionmentioning

confidence: 99%

Effects of Angiotensin on Blood Pressure and Renal Function in Pregnant and Non-Pregnant Rats

Sicińska

Bailie

Rector

1971

Nephron

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The effect of intraperitoneal injections of angiotensin II (100 µg/kg) was examined in pregnant and non-pregnant control rats. The initial blood pressure was higher in the pregnant than in the control animals, but the pregnant rats exhibited a smaller rise in blood pressure in response to angiotensin II. Angiotensin produced a natriuresis in both groups of animals but caused a significant rise in glomerular filtration rate in control animals and a significant fall in glomerular filtration rate in pregnant rats. It is suggested that the differential effect of angiotensin on systemic and renal vascular resistance is altered by pregnancy.

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“…The pressor dose of l-noradrenaline was calculated as the dose of the base (pmol kg-I min-l) necessary to obtain an increase in diastolic blood pressure of 20 mmHg. The normal value in the laboratory was 551 +SFM 192 pmol(93.8+3243 ng) min-' kg-l. A similar method was used to determine the vascular reactivity to angiotension (Kaplan & Silah, 1964). The pressor dose of angiotensin was the amount of angiotensin necessary to obtain an increase in diastolic blood pressure of 20 mmHg; normal value of the laboratory: 6.320.61 pmol (6.3+0.61 ng) min-l kg-'.…”

Section: Methodsmentioning

confidence: 99%

Cardiopulmonary Blood Volume in Borderline Hypertension

et al. 1974

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S U M M A R Y1. A haemodynamic study which included estimation of cardiopulmonary blood volume (CPBV), total blood volume (TBV) and vascular reactivity to noradrenaline was performed in seventeen borderline and sixteen permanent hypertensive patients.2. Borderline hypertensive patients had higher values of cardiac index, stroke index and heart rate when compared with the permanent hypertensive patients, and lower values of blood pressure and total peripheral resistance.3. The CPBVITBV ratio was significantly higher in borderline hypertensive patients. In that group, this ratio was directly correlated with cardiac index, stroke index and the pressor dose of noradrenaline (P ~0.01). 4. In permanent hypertensive patients, none of these correlations was observed.Only the total blood volume was correlated directly with cardiac index and inversely with total peripheral resistance. 5.The study suggests that a redistribution of intravascular volume from peripheral veins to the cardiopulmonary capacitance bed occurs in borderline hypertension when compared with permanent hypertension and that hypertension is related to a neural mechanism in the borderline state and to a volume mechanism in the permanent state.

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The Angiotensin-Infusion Test

Cited by 121 publications

References 13 publications

Plasma Renin Activity and Angiotensin Pressor Dose in Hypertension: Correlation and Diagnostic Implications

Plasma Renin Activity and Angiotensin Pressor Dose in Hypertension: Correlation and Diagnostic Implications

Effects of Angiotensin on Blood Pressure and Renal Function in Pregnant and Non-Pregnant Rats

Cardiopulmonary Blood Volume in Borderline Hypertension

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