No abstract

This is a report of a procedure for the determination of peripheral plasma aldosterone, in which 14C-labeled aldosterone serves as the marker, and the acetylating agent is relatively inexpensive tritium-labeled acetic anhydride of high specific activity. A new method for the chromatographic purification of aldosterone and aldosterone diacetate is presented. This procedure provides a better separation of these two compounds from the unlabeled and labeled impurities.

The excretion of dehydroepiandrosterone glucuronide and sulfate was studied in a group of patients with essential hypertension and a group of normal subjects by a new single-label isotopic-dilution procedure. A very marked decrease in excretion of the sulfate was found in the patients with essential hypertension.

No abstract

No abstract