Effects of Angiotensin on Blood Pressure and Renal Function in Pregnant and Non-Pregnant Rats

Sicińska, Justyna; Bailie, Michael D.; Rector, Floyd C.

doi:10.1159/000179940

Cited by 10 publications

(2 citation statements)

References 6 publications

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“…As glomerular filtration rate is increased in the pregnant rat (Sicinska, Bailie and Rector, 1971) and a large increase in plasma progesterone concentration occurs (Pepe and Rothchild, 1974) which may block the renal effects of aldosterone (Landau and Lugibihl, 1958), it was postulated that the reninaldosterone system would be activated to mediate the essential sodium retention. In an earlier study, Schneider and Mulrow (1973) examined the capacity of adrenals to produce aldosterone, when incubated in vitro, when taken from rats on the day of parturition.…”

Section: Introdugtionmentioning

confidence: 99%

Regulation of Aldosterone in the Rat Effect of Oestrous Cycle, Pregnancy, and Sodium Status

Jp²,

Shulkes

et al. 1978

Aust J Exp Biol Med

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Summary. Whole blood concentrations of aldosterone and corticosterone were measured in female rats on a moderate sodium diet (1-2 mmol/day) during diestrus, proestrus, oestrus and on days 4, 12, 18 of pregnancy. At diestrus, the aldosterone (5-6 ± 4-9 ng/100 ml., n = 4) and corticosterone (10-4 it 10-7 ng/lOO ml, n = 4) concentrations were significantly lower (P < 0-01) than at oestrus when aldosterone and corticosterone concentrations were respectively 15-2 ± 7-8 ng/100 ml (n = 6) and 27-2 ± 12 2 ng/100 ml (n = 6). The blood aldosterone concentration of day-12 pregnant rats, 33-9 ± 7-8 ng/ 100 ml (n = 8), was significantly higher than the values at oestrus and remained elevated at day 18. (Parturition occurs at day 21-22.) Corticosterone values were not elevated during pregnancy, compared to values at oestrus. Sodium loading (7-8 m mol/day) did not suppress blood aldosterone concentrations in non-pregnant rats, but did significantly (P < 0 05) suppress values in the 18-20 day pregnant rat. Plasma renin concentration (PRC), plasma renin substrate (PRS) and derived plasma renin activity (PRA) did not vary significantly during the oestrous cycle, being respectively (18-3 ± 10 7) x 10-Ĝ oldblatt Units/ml, 0-416 ± 0-199 ng/ml, and 5-0 ± 2-6 ng/ml/h in 21 samples. PRC increased significantly by day 11 of gestation, while PRS decreased significantly at day 11 (P < 0-05) and even further by days 18-20 (P < 0-001).The derived PRA was elevated only in 11-14 day pregnant rats (P < 0-05). It is concluded that factors other than renin are responsible for the increase in aldosterone in pregnancy. INTRODUGTIONDuring the course of pregnancy in the rat (21-22 days) there is a great demand for sodium conservation, as a weight gain of approx. 45% of the original maternal body weight is made, 60% of this occurring during the last third of

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Section: Introdugtionmentioning

confidence: 99%

Regulation of Aldosterone in the Rat Effect of Oestrous Cycle, Pregnancy, and Sodium Status

Jp²,

Shulkes

et al. 1978

Aust J Exp Biol Med

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“…In the case of angiotensin II. for instance, this is well docu mented: during normal pregnancy in the human [20] and in the rat [21] the response upon this vasoconstrictor dramat ically decreases. It is conceivable that pregnancy-associated hormones like progesterone and prolactin may be involved, since pseudopregnant rats, with plasma levels of these hor mones similar to those o f pregnant rats [22,23], also show GFR enhancement as measured with the inulin clearance method [24.25].…”

Section: Discussionmentioning

confidence: 88%

The Glomerular Filtration Rate during Pregnancy: Saline Infusion Enhances the Glomerular Filtration Rate in the Pregnant Rat

Faas¹,

Schuiling²,

Klok³

et al. 1996

Kidney Blood Press Res

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The glomerular filtration rate (GFR) of pregnant rats is generally believed to exceed non-pregnant values. This notion is primarily based upon standard inulin clearances. However, the inulin clearance requires continuous infusion of inulin usually dissolved in saline. Since saline infusion per se in pregnancy may influence the GFR, in the present study the effect of saline infusion upon the GFR in pregnant as compared with cyclic rats was investigated using various methods. The standard inulin clearance was compared using the standard ⁵¹Cr-EDTA method which does not require saline infusion. Clearance of inulin dissolved in glucose (5% in distilled water) instead of saline was also tested, while the ⁵¹Cr-EDTA method was employed using additional fluid infusion with either saline or 5% glucose in distilled water in an identical manner as compared with the inulin method. The GFR was also studied in conscious rats using ⁵¹Cr-EDTA clearance with and without fluid infusion. The distribution volume of ⁵¹Cr-EDTA was measured in nephrectomized rats (pregnant and cyclic) with and without saline or glucose infusions. The results show a significant increase of the GFR in pregnant rats as compared with cyclic rats only when saline was infused during the measurement; thus, GFR measurements without fluid infusion or replacement of saline by glucose during the measurements did not show a significant increase of GFR in pregnant rats. The volume of distribution per gram body weight of ⁵¹Cr-EDTA after saline infusion, but not after glucose infusion, was significantly increased as compared with the values obtained without additional infusion. It is concluded that the increase of the GFR seen in pregnant rats when either the ⁵¹Cr-EDTA method or the inulin method is accompanied by saline loading is rather due to infusion of saline in the pregnant animal and not a result of the pregnant condition per se.

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Acute Renal Failure in Pregnancy

Pertuiset¹,

Ganeval²,

Grünfeld³

1986

The Kidney in Pregnancy

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Effects of Angiotensin on Blood Pressure and Renal Function in Pregnant and Non-Pregnant Rats

Cited by 10 publications

References 6 publications

Regulation of Aldosterone in the Rat Effect of Oestrous Cycle, Pregnancy, and Sodium Status

Regulation of Aldosterone in the Rat Effect of Oestrous Cycle, Pregnancy, and Sodium Status

The Glomerular Filtration Rate during Pregnancy: Saline Infusion Enhances the Glomerular Filtration Rate in the Pregnant Rat

Acute Renal Failure in Pregnancy

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