The Analytical Applications of Square Wave Voltammetry on Pharmaceutical Analysis

Dogan‐Topal, Burcu; Özkan, Síbel A.; Uslu, Bengi

doi:10.2174/1875038901003010056

Cited by 48 publications

(3 citation statements)

References 197 publications

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“…Dynamic EC techniques such as fast-scan cyclic voltammetry (FSCV) [74], differential pulse voltammetry (DPV) [75], square wave voltammetry (SWV) [76], amperometry (AMP) [77], and so forth offer great scope for the determination of DA. In these techniques when an electrode potential is applied, the changes in currents are measured.…”

Section: Electrochemical (Ec) Sensorsmentioning

confidence: 99%

Recent Advances in Electrochemical and Optical Sensing of Dopamine

Eddin

Fen

2020

Sensors

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Nowadays, several neurological disorders and neurocrine tumours are associated with dopamine (DA) concentrations in various biological fluids. Highly accurate and ultrasensitive detection of DA levels in different biological samples in real-time can change and improve the quality of a patient’s life in addition to reducing the treatment cost. Therefore, the design and development of diagnostic tool for in vivo and in vitro monitoring of DA is of considerable clinical and pharmacological importance. In recent decades, a large number of techniques have been established for DA detection, including chromatography coupled to mass spectrometry, spectroscopic approaches, and electrochemical (EC) methods. These methods are effective, but most of them still have some drawbacks such as consuming time, effort, and money. Added to that, sometimes they need complex procedures to obtain good sensitivity and suffer from low selectivity due to interference from other biological species such as uric acid (UA) and ascorbic acid (AA). Advanced materials can offer remarkable opportunities to overcome drawbacks in conventional DA sensors. This review aims to explain challenges related to DA detection using different techniques, and to summarize and highlight recent advancements in materials used and approaches applied for several sensor surface modification for the monitoring of DA. Also, it focuses on the analytical features of the EC and optical-based sensing techniques available.

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Section: Electrochemical (Ec) Sensorsmentioning

confidence: 99%

Recent Advances in Electrochemical and Optical Sensing of Dopamine

Eddin

Fen

2020

Sensors

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“…Square wave stripping voltammetry (SWSV) is observed in pre-concentration mode allowing ameliorations of the analyte samples and their quanti cation up to nano-molar concentration. [38][39][40] In the present study, the SWSV method was utilized to determine the relationship between peak current and concentration of LEV. Under the optimized experimental parameters, the SWS voltammograms were recorded for the different concentrations of LEV (72 to 130 µmolL − 1 ) at MoS 2 /PGE in pH 3.0 BR buffer.…”

Section: Determination Of Surface Coverage (γ O ) and Diffusion Coe C...mentioning

confidence: 99%

Development of MoS2 flower-adorned pencil graphite electrode for electro-kinetic investigations and voltammetric quantification of anti-epileptic drug levetiracetam

Agarwal,

Jhankal,

Yadav

et al. 2023

J Appl Electrochem

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The fast, accurate, and affordable determination of anti-epileptic drug levetiracetam (LEV) is the need of time for human health. In this study, an electrochemical sensor platform was proposed for the costeffective and sensitive determination of the levetiracetam based on molybdenum sul de nano-owers adorned pencil graphite electrode (MoS 2 /PGE). The nano-owers of MoS 2 were prepared by a costeffective one-step facile hydrothermal method and the morphology of synthesized MoS 2 micro-owers was characterized via FESEM, XRD, and EDS techniques. Under the optimized experimental conditions, cyclic, linear sweep, and square wave voltammograms of LEV were recorded. The diffusion-controlled electrochemical oxidation of LEV produced one well-de ned irreversible peak in all voltammograms. The various electro-kinetics parameters like diffusion coe cient (D o =1.41×10 − 5 cm 2 s − 1 ), heterogeneous rate constant (K h =9.04×10 − 4 cms − 1 ), electron transfer coe cient (α = 0.66), the surface area of the fabricated electrode (A = 0.0767 cm 2 ) and surface coverage (Γ o = 2.98×10 − 11 molcm − 2 ) were evaluated for the oxidation of LEV at MoS 2 /PGE. The square wave stripping voltammetry (SWSV) method was optimized for the quanti cation of LEV in pharmaceutical samples. The oxidative peak current in SWSV methods varies linearly with LEV concentration within the range 72.0 to 130.0 µmolL − 1 with detection limit (LOD) value of 14.20 µmolL − 1 . The proposed MoS 2 /PGE platform provides a sensitive, low cost and ecofriendly tool for the rapid detection of LEV in clinical samples.

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“…38 This is because ZnO has high electrocatalytic activity that facilitates better electron transport. 16,[39][40][41][42][43][44] The high isoelectric point of ZnO doubtless enables the improvement absorption of analytes, result in a greater current response. [45][46][47][48][49] More importantly, ZnO is an environmentally friendly, cheap, highly stable material (both physically and chemically), biocompatible, and non toxic material.…”

Section: Introductionmentioning

confidence: 99%