The ameliorative effect of quercetin on bisphenol A-induced toxicity in mitochondria isolated from rats

Shirani, Maryam; Alizadeh, Saeid; Mahdavinia, Masoud; Dehghani, Mohammad Amin

doi:10.1007/s11356-018-04119-5

Cited by 48 publications

(22 citation statements)

References 61 publications

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“…In the kidney, BPA lowers the GSH levels and reduces CAT activity, increasing the formation of mitochondrial ROS and causing damage to the mitochondrial membrane. Quercetin restores the antioxidant parameters (GSH and MDA) in kidney tissues, suggesting that renoprotection is mediated by an antioxidant mechanism [ 161 ]. It also increases the activity of ATPase and SDH in the tissues of mice [ 65 , 162 ].…”

Section: Survey Of Antioxidants That Affected Bpa Toxicitymentioning

confidence: 99%

Can Antioxidants Reduce the Toxicity of Bisphenol?

2022

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BPA is still the subject of extensive research due to its widespread use, despite its significant toxicity resulting not only from its negative impact on the endocrine system but also from disrupting the organism’s oxidative homeostasis. At the molecular level, bisphenol A (BPA) causes an increased production of ROS and hence a change in the redox balance, mitochondrial dysfunction, and modulation of cell signaling pathways. Importantly, these changes accumulate in animals and humans, and BPA toxicity may be aggravated by poor diet, metabolic disorders, and coexisting diseases. Accordingly, approaches using antioxidants to counteract the negative effects of BPA are being considered. The preliminary results that are described in this paper are promising, however, it should be emphasized that further studies are required to determine the optimal dosage and treatment regimen to counteract BPA toxicity. It also seems necessary to have a more holistic approach showing, on the one hand, the influence of BPA on the overall human metabolism and, on the other hand, the influence of antioxidants in doses that are acceptable with the diet on BPA toxicity. This is due in part to the fact that in many cases, the positive effect of antioxidants in in vitro studies is not confirmed by clinical studies. For this reason, further research into the molecular mechanisms of BPA activity is also recommended.

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Section: Survey Of Antioxidants That Affected Bpa Toxicitymentioning

confidence: 99%

Can Antioxidants Reduce the Toxicity of Bisphenol?

2022

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“…Besides, the renal system regulates the volume of blood and extracellular fluid, acid-base homeostasis, and electrolyte combination (18). Kidney injuries caused by drugs are common in humans and could disturb these functions (19).…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Micro-Emulsion of Sour Cherry (Prunus cerasus L.) Kernel Extract on Methimazole-Induced Nephrotoxicity in Mice

Kalantari‬

Salimi

Molavinia

et al. 2019

Jundishapur J Nat Pharm Prod

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Background: Microemulsion (ME) is a method that has been developed in the recent years for synthesizing the nano-sized drug, metal or non-metal particles. These systems offer various advantages for drug delivery, such as ease of preparation, complete stability, and high drug solvability in many pharmaceutical applications. Objectives: This study aimed at evaluating the protective effect of sour cherry kernel extract microemulsion on methimazoleinduced nephrotoxicity in mice. Methods: Sixty-four male Swiss albino mice were divided to eight groups; each group consisted of eight mice. Group 1 was served as control, received normal saline; group 2 received base of ME without extract for 10 days; group 3 received a single dose of methimazole (100 mg/kg, ip) as positive control only on the 10th day; groups 4 to 6 received ME extract orally in doses of 250, 500, and 1000 mg/kg, respectively, during 10 days and methimazole (100 mg/kg, ip) on the 10th day; group 7 and 8 received ME extract and extract in dose of 1000 mg/kg for 10 days, respectively. Then, on the 11th day, serum samples were collected and used to determine the levels of serum creatinine (Cr) and blood urea nitrogen (BUN). After removing the kidney, malondialdehyde (MDA) and glutathione (GSH) levels and glutathione peroxidase (GPx) and superoxide dismutase (SOD) activity were also determined. Results: The results obtained from the present study indicated a significant increase in the levels of Cr, BUN and MDA, and decrease of GSH, GPx and SOD by methimazole administration. Pre-treatment with ME extract showed reduction in the levels of Cr, BUN, MDA, and increase of GSH, GPx, and SOD. In addition, these observations were confirmed by histopathological changes of the kidney. Conclusions: The current study showed that the extract had a protective effect on methimazole-induced nephrotoxicity and this effect was more for ME extract.

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“…Chronic inflammation after BPA exposure was associated with activation of JNK and NF-kB-signaling pathways that was followed by upregulation of inflammatory cytokines (Savastano et al, 2015 ; Liao et al, 2016 ). Exogenous exposure to BPA induced mitochondrial damage in INS-1 cells (Lin et al, 2013 ; Shirani et al, 2019 ), along with induction of other proapoptotic proteins (Gong et al, 2017 ; Wang et al, 2017 ; Kaur et al, 2018 ) and cytochrome C release (Hwang et al, 2013 ).…”

Section: Determining Common Mechanisms Associated With Exposure To Edcsmentioning

confidence: 99%

Developmental Exposure to Endocrine Disrupting Chemicals and Its Impact on Cardio-Metabolic-Renal Health

et al. 2021

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Developmental origin of health and disease postulates that the footprints of early life exposure are followed as an endowment of risk for adult diseases. Epidemiological and experimental evidence suggest that an adverse fetal environment can affect the health of offspring throughout their lifetime. Exposure to endocrine disrupting chemicals (EDCs) during fetal development can affect the hormone system homeostasis, resulting in a broad spectrum of adverse health outcomes. In the present review, we have described the effect of prenatal EDCs exposure on cardio-metabolic-renal health, using the available epidemiological and experimental evidence. We also discuss the potential mechanisms of their action, which include epigenetic changes, hormonal imprinting, loss of energy homeostasis, and metabolic perturbations. The effect of prenatal EDCs exposure on cardio-metabolic-renal health, which is a complex condition of an altered biological landscape, can be further examined in the case of other environmental stressors with a similar mode of action.

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The ameliorative effect of quercetin on bisphenol A-induced toxicity in mitochondria isolated from rats

Cited by 48 publications

References 61 publications

Can Antioxidants Reduce the Toxicity of Bisphenol?

Can Antioxidants Reduce the Toxicity of Bisphenol?

Protective Effects of Micro-Emulsion of Sour Cherry (Prunus cerasus L.) Kernel Extract on Methimazole-Induced Nephrotoxicity in Mice

Developmental Exposure to Endocrine Disrupting Chemicals and Its Impact on Cardio-Metabolic-Renal Health

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