The ameliorating effects of tokishakuyakusan in a rat model of implantation failure involves endometrial gland leukemia inhibitory factor and decidualization

Terawaki, Kiyoshi; Saegusa, Yayoi; Sekiguchi, Kyoji; Shimizu, Tomofumi; Takiyama, Mikina; Mutoh, T.; Iizuka, Seiichi; Matsumoto, Chinami; Motoyama, Fukuhito

doi:10.1016/j.jep.2020.113288

Cited by 7 publications

(4 citation statements)

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“…As a molecular mechanism for ovarian function, it has been reported that TSS stimulated progesterone and estradiol-17 beta in rat granulosa cells ( 17 ). Regarding the uterus, Terawaki et al ( 18 ) reported that the ameliorating effects of TSS in a rat model of implantation failure may involve the alleviation of decreased leukemia inhibitory factor production derived from the endometrial gland, and decidualization dysfunction. Certainly, in the current case, we suspect that TSS impacted not only implantation but also miscarriage prevention.…”

Section: Discussionmentioning

confidence: 99%

Sho-Based Kampo Medicine Combined With Assisted Reproductive Technology Is Effective for Refractory Infertility and Early Recurrent Miscarriage: A Case Report

et al. 2021

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Assisted reproductive technology (ART) is an effective treatment developed for infertile couples in the world. As a result, women suffering from infertility benefit from ART treatment. However, even when ART treatment is successfully performed, there are cases where conception is not achieved or maintained. Kampo medicine was originally developed in Japan, and Sho is the central part of Kampo concept. Although it is thought that Kampo medicine is useful for various women-specific symptoms in modern Japan, evidence is still lacking regarding the effectiveness of combination of Sho-based Kampo and Western medicine such as ART. In this article, we report a case of a patient with refractory infertility and early recurrent miscarriage (ERM) of unknown cause who successfully became pregnant with combination therapy of Kampo based on Sho and ART. The patient was a 34 year-old Japanese woman and had been treated with ART in a nearby clinic. In a 3 year period, she had undergone oocyte retrieval twice, frozen embryo transfer (FET) seven times and conceived twice. Since both conceptions ended in miscarriages and pregnancy could not be established thereafter, her clinic referred her to our hospital for Kampo treatment. As result of the diagnosis of her Sho-pattern, we chose Kampo medicine. Finally, she succeeded in conception 1.5 years after beginning treatment and was able to carry the fetus to term successfully. The current case showed that although our patient had been unable to give a birth after undergoing various western medical treatments for infertility, pregnancy was established and kept to term after addition of Sho-based Kampo treatment. Kampo medicine chosen by the Sho-patterns is useful for refractory infertility and ERM. It is important to note that examinations for evaluting the Sho-patterns are essential for selecting appropriate Kampo medicine. Sho-based Kampo leads to an increase in the effectiveness of ART treatment, and accumulation of evidence that clarifies Sho-pattern is required.

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Section: Discussionmentioning

confidence: 99%

Sho-Based Kampo Medicine Combined With Assisted Reproductive Technology Is Effective for Refractory Infertility and Early Recurrent Miscarriage: A Case Report

et al. 2021

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“…Terawaki believed that LIF played an indispensable role in embryo implantation. According to animal experiments, he found that Tokishakuyakusan, a kind of Japanese Kampo commonly used to treat infertility in Japan, could significantly improve the production of LIF protein and the expression of LIF mRNA in endometrial cells and reduce the decidual dysfunction in rats with implantation disorders, resulting in improving embryo implantation conditions, thus treating infertility [78]. In addition, Zishen Yutai pill (kidneynourishing and fetus-raising pill), modified Shoutaiwai recipe (modified ex-longevity fetus recipe), and Bushen Huoxue recipe (kidney-nourishing and blood-promoting recipe) have all been proved by animal experiments to upregulate the expression of integrin αvβ3 and LIF on endometrium to increase endometrial receptivity and embryo implantation rate [79][80][81].…”

Section: Modulation Of the Expression Of Related Factors Andmentioning

confidence: 99%

The Treatment of Complementary and Alternative Medicine on Female Infertility Caused by Endometrial Factors

Lin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Recently, with the development of the social economy, the incidence of infertility has increased year by year. With its complex etiology and diversified syndromes, infertility has become one of the most important diseases that plague the physical and mental health of women of childbearing age worldwide. Endometrial factors as an important part affecting female reproductive capacity, due to which induced repeated abortion and multiple uterine cavity operations occur, can destruct endometrium, failing to provide a normal implantation environment for zygote, thus resulting in infertility. Many patients failed to achieve expected results after receiving conventional treatments such as hormone therapy, assisted reproductive technology (ART), granulocyte colony-stimulating factor (G-CSF) therapy, and cell therapy, then turn to complementary and alternative medicine (CAM) therapies for help. Aiming at clarifying the effectiveness and mechanisms of CAM therapy in the treatment of infertility caused by endometrial factors, our paper systematically searched and studied present related literature on the PubMed, CNKI, and other databases, focusing on the aspects of clinical application and mechanism explorations and highlighting the therapeutic effects of Chinese herbal medicine (CHM), acupuncture, and moxibustion on such diseases. Moreover, this paper also introduces the CAM treatments of traditional Chinese medicine (TCM) retention enema, neuromuscular electrical stimulation (NMES), photobiomodulation therapy, dietary intervention, and other measures for infertility caused by endometrial factors, in order to provide a reference for subsequent basic research and clinical work.

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“…Several reports have suggested that traditional herbal formulas and medicinal herbs successfully improve endometrial receptivity and might be an alternative option for improving the outcome of embryo implantation [192][193][194]. Many herbal formulas have been studied for enhancing the embryo implantation rate in animal studies and clinical study [195][196][197][198][199][200][201][202][203][204][205][206][207][208][209][210][211][212][213]. Among these formulas, Erbu Zhuyu decoction and Tokishakuyakusan (TJ-23, Danggui Shaoyao san in Chinese) have been reported to induce autophagy via the expression of Beclin1 and LC3 [208,214,215].…”

Section: Possible Role Of Autophagy On the Effect Of Medicinal Herbal Drugs As Embryo Implantation Enhancermentioning

confidence: 99%

“…BaelanChagsangBang -- [236] Bangdeyun and its component DS147 -- [196,197] Buganshen recipe -- [198] BuShenAnTai recipe -- [201] Bushen Tiaoxue Granules and Kunling Wan -- [202] Dingkun Pill -- [206,207,212] Erbu Zhuyu decoction -Increases the Beclin1 and LC3B [204,208] Gushen'antai pills -- [195] Liuwei Dihuang Granule -- [199] Shoutaiwai recipe -- [200] Tokishakuyakusan(Danggui Shaoyao san) -Induces autophagy and mitophagy via increasing PINK1 and LC3 but reducing p62 [203,214,215] Wenshen Yangxue decoction -- [205,211] Xianziyizhen Recipe -- [237] Yeosin-san Paeonia lactiflora and Cyperus rotundus - [213,238] Yiqixue buganshen recipe -- [198] Zhuyun recipe -- [210] Angelica gigas Decusirol Block autophagic flux by suppressing cathepsin C expression [216,221] Cnidium officinale -- [239] Cyperus rotundus -Increases LC3B II/LC3B and Beclin1 [223,229] Paeonia lactiflora Paeoniflorin Induces autophagy via inhibition of AKT/mTOR [114,225,230] Panax quiquefolius (American Ginseng) Ginsenoside Rb1 and Rg1…”

Section: Name Active Components Role In Autophagy Referencesmentioning

confidence: 99%

Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation

Park

Cho

et al. 2021

Pharmaceuticals

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Infertility is an emerging health issue worldwide, and female infertility is intimately associated with embryo implantation failure. Embryo implantation is an essential process during the initiation of prenatal development. Recent studies have strongly suggested that autophagy in the endometrium is the most important factor for successful embryo implantation. In addition, several studies have reported the effects of various natural products on infertility improvement via the regulation of embryo implantation, embryo quality, and endometrial receptivity. However, it is unclear whether natural products can improve embryo implantation ability by regulating endometrial autophagy. Therefore, we performed a literature review of studies on endometrial autophagy, embryo implantation, natural products, and female infertility. Based on the information from these studies, this review suggests a new treatment strategy for female infertility by proposing natural products that have been proven to be safe and effective as endometrial autophagy regulators; additionally, we provide a comprehensive understanding of the relationship between the regulation of endometrial autophagy by natural products and female infertility, with an emphasis on embryo implantation.

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The ameliorating effects of tokishakuyakusan in a rat model of implantation failure involves endometrial gland leukemia inhibitory factor and decidualization

Cited by 7 publications

References 50 publications

Sho-Based Kampo Medicine Combined With Assisted Reproductive Technology Is Effective for Refractory Infertility and Early Recurrent Miscarriage: A Case Report

Sho-Based Kampo Medicine Combined With Assisted Reproductive Technology Is Effective for Refractory Infertility and Early Recurrent Miscarriage: A Case Report

The Treatment of Complementary and Alternative Medicine on Female Infertility Caused by Endometrial Factors

Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation

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