The Treatment of Complementary and Alternative Medicine on Female Infertility Caused by Endometrial Factors

Abstract

Recently, with the development of the social economy, the incidence of infertility has increased year by year. With its complex etiology and diversified syndromes, infertility has become one of the most important diseases that plague the physical and mental health of women of childbearing age worldwide. Endometrial factors as an important part affecting female reproductive capacity, due to which induced repeated abortion and multiple uterine cavity operations occur, can destruct endometrium, failing to provide a normal implantation environment for zygote, thus resulting in infertility. Many patients failed to achieve expected results after receiving conventional treatments such as hormone therapy, assisted reproductive technology (ART), granulocyte colony-stimulating factor (G-CSF) therapy, and cell therapy, then turn to complementary and alternative medicine (CAM) therapies for help. Aiming at clarifying the effectiveness and mechanisms of CAM therapy in the treatment of infertility caused by endometrial factors, our paper systematically searched and studied present related literature on the PubMed, CNKI, and other databases, focusing on the aspects of clinical application and mechanism explorations and highlighting the therapeutic effects of Chinese herbal medicine (CHM), acupuncture, and moxibustion on such diseases. Moreover, this paper also introduces the CAM treatments of traditional Chinese medicine (TCM) retention enema, neuromuscular electrical stimulation (NMES), photobiomodulation therapy, dietary intervention, and other measures for infertility caused by endometrial factors, in order to provide a reference for subsequent basic research and clinical work.

LncRNAs 60248.51 and 9826.1 are identified as potential regulators of endometrial receptivity in Tibetan Northwest Cashmere goats

“…EGF stimulates the growth of glandular cells in the proliferative and secretory endometrium and facilitates the epithelial-mesenchymal transition (Okada et al, 2022). CSF stimulates cell proliferation, which has no change in the menstrual cycle, but its concentration increases significantly in early pregnancy (Lin et al, 2022). In our study, based on our sequencing analysis, we screened two of the most upregulated lncRNAs in the RE tissue and explored their roles in primary goat endometrial epithelial cells through adenovirus-mediated overexpression experiments.…”

Network Pharmacology Analysis of the Mechanisms Underlying the Therapeutic Effects of Yangjing Zhongyu Tang on Thin Endometrium

“…The compound is clinically used for the treatment of infertility, polycystic ovary syndrome, thin endometrium, repeated implant failure, and premature ovarian insufficiency. [6][7][8] While clinical studies to date have confirmed that YJZYT increases endometrial thickness, improves endometrial receptivity, and augments the clinical pregnancy rate, its specific mechanisms of action are yet to be established. 9,10 Despite considerable research, the pharmacological interpretation of TCM prescriptions still faces significant challenges, which greatly hinders the widespread clinical application of TCM worldwide.…”

Can Manual Therapy and Massage Be Used as Complementary Methods for Female Infertility in Different Age Groups?

“…They may be uninsured in some circumstances and countries [6]. Therefore, many patients utilize complementary medicine to improve the efficacy of their treatment and minimize potential side effects [7]. For example, data from Turkey and Iran reveal that around half of infertile patients have used complementary medicine methods.…”