Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation

Park, Hyerin; Cho, Min Kyoung; Do, Yoonju; Park, Jang-Kyung; Bae, Sung Jin; Joo, Jong‐Kil; Ha, Ki‐Tae

doi:10.3390/ph15010053

Cited by 9 publications

(4 citation statements)

References 251 publications

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“…IL1B is shown to participate in implantation by indirectly increasing concentration of intracellular cAMP by upregulating PTGS2 and PGE2, thus reorganizing the actin cytoskeleton [ 33 ]. It is demonstrated that in the mid-to-late-secretory phase endometrium, where implantation occurs, and the concentrations of ovarian steroid hormones are highest, high expression levels of cytokines such as LIF and IL6 are detected [ 38 ]. Immune cells, such as dNK, play a role in pathological pregnancy and are related to preeclampsia, recurrent pregnancy loss, endometriosis, and recurrent implantation failure (RIF).…”

Section: Discussionmentioning

confidence: 99%

Characterization of Epigenetic and Molecular Factors in Endometrium of Females with Infertility

et al. 2022

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Infertility is one of the most rapidly increasing global health concerns of the 21st century. Embryo quality and endometrial thickness and receptivity are the main factors for successful embryo implantation and pregnancy development. Nevertheless, until now, there has been a lack of understanding about the regulation of human endometrium function and its structure. This raises the demand for more research of the human endometrium in these fields. In our study, we analyzed the genetic and epigenetic changes of endometrial tissue’s samples isolated from females admitted for treatment due to male infertility and females diagnosed with reproductive pathologies, who are preparing for assisted reproductive technologies procedures. Using real-time polymerase chain reaction method, we demonstrated that endometrium of females with reproductive pathology has significantly upregulated decidualization related genes HAND2, MUC1, CSF2, increased expression of angiogenesis related gene PDGFA, and increases of overall immune response and inflammation-related genes expression with significant changes of RELA and CXCL10 genes expression. Females with reproductive pathology have altered endometrium epigenetic regulation since expression of miRNAs—specifically, miRNA-34a, miRNA-223, and miRNA-125b—is lower in endometrium of females with reproductive pathology. Our findings suggest that the potential changes in genetic and epigenetic profile of endometrium from females with reproductive pathology could enrich the knowledge in the field of core biological knowledge and treatment of reproductive impairments.

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Section: Discussionmentioning

confidence: 99%

Characterization of Epigenetic and Molecular Factors in Endometrium of Females with Infertility

et al. 2022

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“…T lymphocytes that have become overly active may injure normal tissues that display the target antigen, putting healthy cells at risk in addition to targeting viral antigens. Regular cells produce neoantigens, cancer antigens, and auto-antigens in reaction to cell disruption caused by cytotoxic T lymphocytes, worsening the injury by 'targeting' body cells [80]. Furthermore, activation of Th1 and Th17 T cells after CAR-T cell therapy increases serum cytokine output, like IFN-, IL-17, and IL-6, which typically leads to cytokine release syndrome (CRS).…”

Section: Mechanisms Underlying Iraes (Immune Related Adverse Events)mentioning

confidence: 99%

Emerging Management Approach for the Adverse Events of Immunotherapy of Cancer

et al. 2022

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Immunotherapy, which stimulates the body’s immune system, has received a considerable amount of press in recent years because of its powerful benefits. Cancer immunotherapy has shown long-term results in patients with advanced disease that are not seen with traditional chemotherapy. Immune checkpoint inhibitors, cytokines like interleukin 2 (IL-2) and interferon-alpha (IFN), and the cancer vaccine sipuleucel-T have all been licensed and approved by the FDA for the treatment of various cancers. These immunotherapy treatments boost anticancer responses by stimulating the immune system. As a result, they have the potential to cause serious, even fatal, inflammatory and immune-related side effects in one or more organs. Immune checkpoint inhibitors (ICPIs) and chimeric antigen receptor (CAR) T-cell therapy are two immunotherapy treatments that are increasingly being used to treat cancer. Following their widespread usage in the clinic, a wave of immune-related adverse events (irAEs) impacting virtually every system has raised concerns about their unpredictability and randomness. Despite the fact that the majority of adverse effects are minimal and should be addressed with prudence, the risk of life-threatening complications exists. Although most adverse events are small and should be treated with caution, the risk of life-threatening toxicities should not be underestimated, especially given the subtle and unusual indications that make early detection even more difficult. Treatment for these issues is difficult and necessitates a multidisciplinary approach involving not only oncologists but also other internal medicine doctors to guarantee quick diagnosis and treatment. This study’s purpose is to give a fundamental overview of immunotherapy and cancer-related side effect management strategies.

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“…Hence, natural product as autophagy modulator has been proposed, owing to their safe profiles whilst showing high effectiveness to diminish tumor cells ( Zhang Q. Y. et al, 2018 ; Rahman et al, 2020 ; Al-Bari et al, 2021 ). Natural product to regulate autophagy is also a novel therapeutic approach in improving fertility ( Zhu et al, 2019 ; Park et al, 2021 ). In addition, natural products can be used to target multiple pathways, thus providing greater flexibility and potential for a variety of cancer types and stages.…”

Section: The Role Of Autophagy In Reproductive Cancermentioning

confidence: 99%

Green Tea Epigallocatechin-3-Gallate Regulates Autophagy in Male and Female Reproductive Cancer

Hung

Chen

et al. 2022

Front. Pharmacol.

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With a rich abundance of natural polyphenols, green tea has become one of the most popular and healthiest nonalcoholic beverages being consumed worldwide. Epigallocatechin-3-gallate (EGCG) is the predominant catechin found in green tea, which has been shown to promote numerous health benefits, including metabolic regulation, antioxidant, anti-inflammatory, and anticancer. Clinical studies have also shown the inhibitory effects of EGCG on cancers of the male and female reproductive system, including ovarian, cervical, endometrial, breast, testicular, and prostate cancers. Autophagy is a natural, self-degradation process that serves important functions in both tumor suppression and tumor cell survival. Naturally derived products have the potential to be an effective and safe alternative in balancing autophagy and maintaining homeostasis during tumor development. Although EGCG has been shown to play a critical role in the suppression of multiple cancers, its role as autophagy modulator in cancers of the male and female reproductive system remains to be fully discussed. Herein, we aim to provide an overview of the current knowledge of EGCG in targeting autophagy and its related signaling mechanism in reproductive cancers. Effects of EGCG on regulating autophagy toward reproductive cancers as a single therapy or cotreatment with other chemotherapies will be reviewed and compared. Additionally, the underlying mechanisms and crosstalk of EGCG between autophagy and other cellular processes, such as reactive oxidative stress, ER stress, angiogenesis, and apoptosis, will be summarized. The present review will help to shed light on the significance of green tea as a potential therapeutic treatment for reproductive cancers through regulating autophagy.

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Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation

Cited by 9 publications

References 251 publications

Characterization of Epigenetic and Molecular Factors in Endometrium of Females with Infertility

Characterization of Epigenetic and Molecular Factors in Endometrium of Females with Infertility

Emerging Management Approach for the Adverse Events of Immunotherapy of Cancer

Green Tea Epigallocatechin-3-Gallate Regulates Autophagy in Male and Female Reproductive Cancer

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