The Ambivalent Function of YAP in Apoptosis and Cancer

Zhang, Xianbin; Abdelrahman, Ahmed; Vollmar, Brigitte; Zechner, Dietmar

doi:10.3390/ijms19123770

Cited by 49 publications

(46 citation statements)

References 133 publications

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“…Several studies have confirmed the oncogenic role of YAP in modulating tumorigenesis in a group of human cancers [24][25][26][27][28] . For example, YAP gene is amplified in TNBC and liver cancer.…”

Section: Discussionmentioning

confidence: 89%

Regulation of Hippo signaling and triple negative breast cancer progression by an ubiquitin ligase RNF187

Wang

Kong

et al. 2020

Oncogenesis

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Breast cancer is the most common malignancy for women worldwide, while Triple Negative Breast Cancer (TNBC) accounts for 20% in all patients. Compared with estrogen receptor positive breast cancer, which could be effectively controlled via endocrine therapy, TNBC is more aggressive and worse in prognosis. It is therefore urgent and necessary to develop a novel therapeutic strategy for TNBC treatment. Recent studies identified Hippo signaling is highly activated in TNBC, which could be a driving pathway for TNBC progression. In our study, we determine RNF187 as a negative regulator for Hippo signaling activation. RNF187 depletion significantly decreases cell migration and invasion capacity in TNBC. These effects could be rescued by further YAP depletion. Depletion of RNF187 increases the YAP protein level and Hippo signaling target genes, such as CTGF and CYR61 in TNBC. Immuno-precipitation assay shows that RNF187 associates with YAP, promoting its degradation possibly via inducing YAP K48-dependent polyubiquitination. Interestingly, Our clinical data reveals that RNF187 reversely correlates with YAP protein level and Hippo target genes. RNF187 tends to correlate with good prognosis in TNBC patients. Our study provides evidence to establish a proteolytic mechanism in regulation Hippo signaling activation in TNBC.

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Section: Discussionmentioning

confidence: 89%

Regulation of Hippo signaling and triple negative breast cancer progression by an ubiquitin ligase RNF187

Wang

Kong

et al. 2020

Oncogenesis

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“…In recent years, several studies have found that the Hippo signalling pathway can promote tumour invasion and metastasis via EMT 16‐19 . And the molecular mechanism through which the Hippo pathway activates apoptosis is realized via p73 20‐22 . According to researchers, such as Yoon et al, 23 the tumour suppressor p73 mediates apoptosis by regulating the antiapoptosis regulator Bcl‐xL.…”

Section: Introductionmentioning

confidence: 99%

Eva‐1 homolog A promotes papillary thyroid cancer progression and epithelial‐mesenchymal transition via the Hippo signalling pathway

Lin

Wen

Zheng

et al. 2020

J Cellular Molecular Medi

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Recently, the incidence of thyroid cancer is increasing worldwide. Papillary thyroid cancer (PTC) is the most common histological type of thyroid cancer. Whole‐transcriptome sequence analysis was performed to further understand the primary molecular mechanisms of the occurrence and progression of PTC. Results showed that Eva‐1 homolog A (EVA1A) may be a potential gene for the PTC‐associated gene in thyroid cancer. In this work, the role of EVA1A expression in thyroid cancer was investigated. Real‐time PCR was performed to detect the expression level of EVA1A in 43 pairs of PTC and four thyroid cancer cell lines. The Cancer Genome Atlas (TCGA) database was used to evaluate the relationship between the expression level of EVA1A and the pathological feature of PTC. The logistic regression analysis of the TCGA data set indicated that the expression of EVA1A was an independent risk factor for tumour, nde and metastasis (TNM) in PTC. This study shows the down‐regulation of EVA1A inhibited the colony formation, proliferation, migration and invasion of PTC cell lines. In the protein level, knockdown of EVA1A can regulate the expression of N‐cadherin, vimentin, Bcl‐xL, Bax, YAP and TAZ. This study indicated that EVA1A was an oncogene associated with PTC.

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“…YAP are nuclear localized in aggressive cancers. Thus, co expression of CD166 and YAP could be prognostic in cancer (Zhang et al, 2018). This study showed CD166/YAP down regulated HCC treated with HEAII and HEAIP compare to that HCC non-treatment.…”

Section: Discussionmentioning

confidence: 56%

Anti-cancer Effects of Azadirachta indica in Diethylnitrosamine-Induced Hepatocellular Carcinoma in Wistar Rats

2020

IJITEE

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 Abstract: Hepatocellular carcinoma (HCC) is a primary liver cancer and has a high rate of mortality. Exploration of local herbal as a chemo-preventive drug has been conducted. This present study aimed to observe the anti-cancer effect of hydroethanolic extracts of Azadirachta indica both Indonesia (HEAII) and the Philippines (HEAIP) on diethylnitrosamine (DEN)-induced HCC on Wistar rat model. VEGF/FGF2/CD166/YAP were evaluated using immunohistochemistry. VEGF/FGF2/CD166/YAP were down-regulated in HCC treated with HEAII and HEAIP compare to that non-treatment HCC. Liver function (aminotransferase (AST) and aminotransferase (ALT) activities) was evaluated from serum. Value of AST and ALT were abnormal in the non-treatment HCC and normal in the HCC treated. These results indicated that both extracts were found to possess anti-cancer activity in HCC.Keywords: hepatocelullar carcinoma; Azadirachta indica; cluster differential 166 (CD166); fibroblast growth factor 2(FGF-2); yes associated protein (YAP); vascular endothelial growth factor (VEGF)

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The Ambivalent Function of YAP in Apoptosis and Cancer

Cited by 49 publications

References 133 publications

Regulation of Hippo signaling and triple negative breast cancer progression by an ubiquitin ligase RNF187

Regulation of Hippo signaling and triple negative breast cancer progression by an ubiquitin ligase RNF187

Eva‐1 homolog A promotes papillary thyroid cancer progression and epithelial‐mesenchymal transition via the Hippo signalling pathway

Anti-cancer Effects of Azadirachta indica in Diethylnitrosamine-Induced Hepatocellular Carcinoma in Wistar Rats

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