The Alzheimer's disease assessment scale

The cognitive subscale of the Alzheimers Disease Assessment Scale (ADAS-Cog) is widely used for the evaluation of dementia and is very popular in dementia drug trials because of the characteristics of the scale. The objective of the present study was to adapt the ADASCog for use for the Brazilian population. A major problem is that education is variable, a fact that may influence performance in cognitive evaluation. This study was conducted on a control group (CG) of 96 subjects (25 males and 71 females aged 68 ± 8.6 years) and on 44 Alzheimers disease (AD) patients (19 males and 25 females aged 72 ± 6.4 years) with mild dementia (Clinical Dementia Rating score 1). For statistical analysis groups were divided into three educational levels: I, 0-4 years of schooling (65 CG/20 AD); II, 5-11 years of schooling (19 CG/7 AD), and III, 12 or more years of schooling (12 CG/17 AD). The battery was applied according to original instructions. Total mean score for CG and AD was 10.9 and 22.9 for level I, 7.8 and 22.4 for level II, and 6.2 and 15.4 for level III, respectively. These results indicate that our version of the ADAS-Cog is useful to identify mild dementia, though there may be an overlapping when comparing high education demented with low education non-demented subjects.

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“…There were no significant differences with respect to gender, a finding similar to that obtained in other reports (13,17,25,26).…”

Section: Discussionsupporting

confidence: 92%

The cognitive subscale of the "Alzheimer's Disease Assessment Scale" in a Brazilian sample

Schultz

Siviero

Bertolucci

2001

Braz J Med Biol Res

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“…From a psychometric perspective, there is an usual rate of progression which is frequently measured by one instrument exclusively through quantitative rating. Nevertheless, most studies employ superficial screening tests and rarely monitor functionality or qualitative aspects in these patients 17,18,19 . The results of this study may direct future developments with regard to specific techniques to deal with moderately and severely impaired AD patients.…”

Section: Discussionmentioning

confidence: 99%

Is there correlation between cognition and functionality in severe dementia? The value of a performance-based ecological assessment for Alzheimer’s disease

Wajman

Oliveira

Marin

et al. 2014

Arq. Neuro-Psiquiatr.

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Objective: Besides significant cognitive decline, patients in later stages of Alzheimer's disease (AD) also present global functional impairment, usually reported by their caregivers. This study searched for preserved activities of daily living by investigating correlations among specific instruments for severe dementia with a performance-based functional scale. Method: A sample of 95 moderate to severe AD patients and their caregivers underwent a neuropsychological battery consisting of screening tools, the Functional Assessment Staging Test (FAST), the Severe Mini-Mental State Examination (MMSEsev) and a performance-based ecological scale, the Performance Test of Activities of Daily Living (PADL). Results: Consistent findings emerged from the comparisons among tests. PADL showed significant statistical correlation with MMSEsev (r,0.001), according to FAST subdivisions. Conclusion: Upon suspicion of unreliable caregiver reports, ecological scales may be useful for disease staging. Variable degrees of functionality and cognition may be present even in later stages of AD, requiring proper assessment.Keywords: Alzheimer disease, neuropsychology, activities of daily living. RESUMOObjetivo: Além do significativo declínio cognitivo, pacientes em estágios avançados da doença de Alzheimer (DA) também apresentam prejuízo funcional global. Este estudo investigou atividades de vida diária correlacionando teste específico para a demência grave, com escala funcional baseada no desempenho. Método: 95 pacientes com DA foram submetidos a uma bateria neuropsicológica composta por instrumentos de rastreio, a escala Functional Assessment Staging Test (FAST), o Mini-exame do Estado Mental grave (MEEMg) e escala ecológica baseada no desempenho: a Performance Test of Activities of Daily Living (PADL). Resultados: Achados consistentes emergiram da comparação entre os instrumentos. De acordo com as subdivisões da escala FAST, a PADL apresentou significativa correlação estatística com o MEEMg (r,0.001). Conclusão: Na suspeita de relato pouco confiável por parte do cuidador, escalas ecológicas podem ser úteis no estadiamento da doença. Igualmente à cognição, variados graus de funcionalidade estão presentes mesmo em fases avançadas da DA, exigindo avaliação adequada.Palavras-chave: doença de Alzheimer, neuropsicologia, atividades de vida diária.Dementias are a worldwide burden to public health systems. Given the demographic changes with a global aging trend ( faster in developing countries), estimates on the rising prevalence of these disorders are discouraging, considering associated costs in primary, secondary and tertiary levels of care . As suggested by current guidelines 2 , the progressive course of dementia might be classified in three main stages: mild -there is still some aptitude for independent life, despite the impact on instrumental activities of daily living; moderate -the abilities for independent living are limited and supervision is needed in many activities; severerestricted independence for all activities, incl...

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“…These transformations introduce potential for measurement error. Doraiswamy and colleagues 135 report analysis of the relationship between ADAScog and MMSE, reporting a highly significant correlation. The current review's examination of the relationship used to convert scores from ADAS-cog to MMSE (using published data where both outcomes are reported) indicates that it is a reasonable reflection of the two cognitive measures (although consideration of the entire continuum of possible scores was not possible).…”

Section: Comments On Industry Submission For Galantaminementioning

confidence: 99%

The clinical and cost-effectiveness of donepezil, rivastigmine, galantamine and memantine for Alzheimer's disease

Loveman

Green²,

Kirby³

et al. 2006

Health Technol Assess

163

114

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The Alzheimer's disease assessment scale

Cited by 150 publications

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The cognitive subscale of the "Alzheimer's Disease Assessment Scale" in a Brazilian sample

The cognitive subscale of the "Alzheimer's Disease Assessment Scale" in a Brazilian sample

Is there correlation between cognition and functionality in severe dementia? The value of a performance-based ecological assessment for Alzheimer’s disease

The clinical and cost-effectiveness of donepezil, rivastigmine, galantamine and memantine for Alzheimer's disease

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