The alkaloids of Grotalaria maypurensis H. B. &amp; K

Culvenor, C. C. J.; Sawhney, RS; Smith, LW

doi:10.1071/ch9682135

Cited by 3 publications

(2 citation statements)

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“…The C. maypurensis seeds (voucher No. COL586229) contained 7-hydroxy-1-methylene-8pyrrolizidine, reported previously [25,61], but supinidine was also found. These two PAs are structural isomers with the same formula C 8 H 13 NO but with different mass spectra (Peaks No.…”

Section: Diversity Of Pas In Crotalaria Sppsupporting

confidence: 68%

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LC/MS study of the diversity and distribution of pyrrolizidine alkaloids in Crotalaria species growing in Colombia

Prada

Stashenko

Martı́nez

2020

J of Separation Science

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Hepatotoxic and genotoxic pyrrolizidine alkaloids have been involved in the acute poisoning of animals and humans. Crotalaria (Fabaceae) species contain these alkaloids. In this work, the diversity and distribution of pyrrolizidine alkaloids in roots, leaves, flowers, and seeds of Crotalaria pallida, Crotalaria maypurensis, Crotalaria retusa, Crotalaria spectabilis, Crotalaria incana, and Crotalaria nitens were studied. Matrix solid-phase dispersion and ultra-highperformance liquid chromatography coupled with Orbitrap mass spectrometry were successfully employed in pyrrolizidine alkaloids extraction and analysis, respectively. Forty-five pyrrolizidine alkaloids were detected and their identification was based on the mass spectrometry accurate mass measurement and fragmentation pattern analysis. The cyclic retronecine-type diesters monocrotaline, crotaleschenine, integerrimine, usaramine, and their N-oxides were predominantly present. Five novel alkaloids were identified for the first time in Crotalaria species, namely 14-hydroxymonocrotaline, 12-acetylcrotaleschenine, 12-acetylmonocrotaline, 12-acetylintegerrimine, and dihydrointegerrimine. Due to a lack of commercially available standards, the response factor of monocrotaline was used for quantification of pyrrolizidine alkaloids and their N-oxides. Seeds and flowers possessed higher pyrrolizidine alkaloids amounts than roots and leaves. Due to their 1,2-unsaturated pyrrolizidine alkaloids content, the ingestion of Crotalaria plant seeds or other parts through herbal products, infusions, or natural remedies is a serious health threat to humans and livestock.

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Section: Diversity Of Pas In Crotalaria Sppsupporting

confidence: 68%

“…In contrast, C. maypurensis seeds from another location (voucher No. COL582805) contained integerrimine, usaramine, macronecine, and laburnine but not 7-hydroxy-1-methylene-8-pyrrolizidine [61].…”

Section: Diversity Of Pas In Crotalaria Sppmentioning

confidence: 99%