Pyrrolizidine alkaloid profiles in Crotalaria species from Brazil: Chemotaxonomic significance

Flores, Andréia Silva; Tozzi, Ana Maria Goulart de Azevedo; Trigo, José Roberto

doi:10.1016/j.bse.2009.06.001

Cited by 47 publications

(45 citation statements)

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“…Compound II was isolated from Fraction 4 and identified as madurensine based on spectroscopic analysis reported by previous researchers (Verdoorn and Van Wyk, 1992). (Atal and Kapur, 1966, Abegaz et al, 1987Asres et al, 2004and Flores et al, 2009 and was found together with trans-anacrotine to be the only alkaloids in the seeds of Crotalaria capensis (Verdoorn and Van Wyk, 1992) (Fig. 2).…”

Section: Isolated Compounds Via Bioassay-guided Fractionationmentioning

confidence: 89%

In vitro chemo-preventative activity of Crotalaria agatiflora subspecies agatiflora Schweinf

Roux

Hussein

Lall

2011

Journal of Ethnopharmacology

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Ethnopharmacological relevance: Crotalaria species have been widely used in Chinese traditional medicine to treat several types of internal cancers. Crotalaria agatiflora is used as a medicinal plant in several African countries for the treatment of bacterial and viral infections as well as for cancer. Materials and methods:Water and ethanol extracts of the leaves of C. agatiflora were evaluated for cytotoxcity on four cancerous and one noncancerous cell lines, using XTT (Sodium 3' -[1-(phenyl amino-carbonyl)-3,4-tetrazolium]-bis-[4-methoxy-6-nitro) benzene sulfonic acid hydrate) colorimetric assay. Antioxidant activity was determined using DPPH (1,1-Diphenyl-2-picryl hydrazyl). Light microscopy (eosin and hematozylin staining) and flow cytometry (Annexin-V and propidium iodide) were used to evaluate the mechanism of action of the ethanol extract and one of the isolated compounds. Results Conclusions:The results indicated that C. agatiflora possesses potential chemopreventative and therapeutic properties. The exact mechanism of action should still be determined in future studies.It is hypothesised that the ethanolic extract as well as madurensine induces autophagy, which in prolonged circumstances may lead to autophagic cell death.

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Section: Isolated Compounds Via Bioassay-guided Fractionationmentioning

confidence: 89%

In vitro chemo-preventative activity of Crotalaria agatiflora subspecies agatiflora Schweinf

Roux

Hussein

Lall

2011

Journal of Ethnopharmacology

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“…Potential compounds for future studies are hydrogenated sesquiterpenes, sesquiterpene lactones and phenolic compounds in the Asteraceae (e.g. Speiser et al 1992;Leiss et al 2009; J.R. Trigo, personal observation) and non-protein amino acids in seeds of Crotalaria (Flores et al 2009 and references therein).…”

Section: Discussionmentioning

confidence: 98%

“…Crotalaria) (Hartmann and Witte 1995;Trigo et al 2003;Jenett-Siems et al 2005;Frölich et al 2006;Brehm et al 2007;Flores et al 2009).…”

Section: Introductionunclassified

Effects of pyrrolizidine alkaloids through different trophic levels

Trigo¹

2010

Phytochem Rev

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“…One color contained 2 μl of 20 % aqueous sucrose; the other flower color contained 2 μl of 20 % aqueous sucrose and 1 μg/ μl of the PA monocrotaline. Monocrotaline was obtained 98 % pure from seeds of Crotalaria spectabilis (Flores et al 2009), following the PA extraction and purification methods described by Trigo et al (1996).…”

Section: Methodsmentioning

confidence: 99%

Southern Monarchs do not Develop Learned Preferences for Flowers With Pyrrolizidine Alkaloids

2015

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Danaus butterflies sequester pyrrolizidine alkaloids (PAs) from nectar and leaves of various plant species for defense and reproduction. We tested the hypothesis that the southern monarch butterfly Danaus erippus shows innate preferences for certain flower colors and has the capacity to develop learned preferences for artificial flowers presenting advantageous floral rewards such as PAs. We predicted that orange and yellow flowers would be innately preferred by southern monarchs. Another prediction is that flowers with both sucrose and PAs would be preferred over those having sucrose only, regardless of flower color. In nature, males of Danaus generally visit PA sources more often than females, so we expected that males of D. erippus would exhibit a stronger learned preference for PA sources than the females. In the innate preference tests, adults were offered artificial non-rewarding yellow, orange, blue, red, green, and violet flowers. Orange and yellow artificial flowers were most visited by southern monarchs, followed by blue and red ones. No individual visited either green or violet flowers. For assessing learned preferences for PA flowers over flowers with no PAs, southern monarchs were trained to associate orange flowers with sucrose plus the PA monocrotaline vs. yellow flowers with sucrose only; the opposite combination was used to train another set of butterflies. In the tests, empty flowers were offered to trained butterflies. Neither males nor females showed learned preferences for flower colors associated with PAs in the training set. Thus, southern monarchs resemble the sister species Danaus plexippus in their innate preferences for orange and yellow flowers. Southern monarchs, similarly to temperate monarchs, might not be as PA-demanding as are other danaine species.

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Pyrrolizidine alkaloid profiles in Crotalaria species from Brazil: Chemotaxonomic significance

Cited by 47 publications

References 50 publications

In vitro chemo-preventative activity of Crotalaria agatiflora subspecies agatiflora Schweinf

In vitro chemo-preventative activity of Crotalaria agatiflora subspecies agatiflora Schweinf

Effects of pyrrolizidine alkaloids through different trophic levels

Southern Monarchs do not Develop Learned Preferences for Flowers With Pyrrolizidine Alkaloids

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