The Action of Certain Antibiotics and Antibiotic Combinations Against Proteus Mirabilis With Demonstration of in Vitro Synergism and Antagonism

Kaye, Donald; Mg, Koenig; Ew, Hook

doi:10.1097/00000441-196109000-00007

Cited by 16 publications

(3 citation statements)

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“…The use of such a combination may have clinical success-a possible synergisjh (98,99). Other types of drug combinations have also exhibited both enhanced bactericidal activity against Proteus and some clinical success (100,101). In patients with chronic urinary tract infection associated with various gram negative bacteria, McCabe & Jackson (64) selected specific drug combinations which exhibited synergistic action against the offending microorganism.…”

Section: Dynamics Of Combined Antimicrobial Drug Actionmentioning

confidence: 99%

The Use of Combinations of Antimicrobial Drugs

Jawetz¹

1968

Annu. Rev. Pharmacol.

112

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Section: Dynamics Of Combined Antimicrobial Drug Actionmentioning

confidence: 99%

The Use of Combinations of Antimicrobial Drugs

Jawetz¹

1968

Annu. Rev. Pharmacol.

112

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“…In 1962, Plotz and Davis demonstrated synergism between penicillin and streptomycin for Escherichia coli, and presented evidence that the basis of this interaction was the increased penetration into the bacterial cell by the aminoglycoside as a result of penicillin-induced, sublethal damage to the bacterial membrane (23). Other investigators have demonstrated synergistic interaction between penicillin, ampicillin, and' carbenicillin or other semisynthetic penicillins plus various aminoglycosides against several Enterobacteriaceae, including species of Proteus, Klebsiella, Enterobacter, and Serratia (5,6,10,14,29,30).…”

Section: Resultsmentioning

confidence: 99%

In Vitro Synergism Between Carbenicillin and Aminoglycosidic Aminocyclitols Against Acinetobacter calcoaceticus var. anitratus

Glew

Moellering

Buettner

1977

Antimicrob Agents Chemother

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Acinetobacter caleoaceticus var. anitratus is a nonfermentative, gram-negative bacillus that has been demonstrated to cause severe infections, usually in hospitalized patients. Since mild to moderate resistance of A. calcoaceticus to one or more aminoglycosidic aminocyclitols has been noted to occur, a study was undertaken to evaluate the activity of combinations of carbenicillin with either kanamycin, tobramycin, or gentamicin against 28 isolates of A. calcoaceticus obtained from clinical sources. Synergism (defined as at least 100-fold-increased killing at 24 h by the combination as compared with the most efficacious of the individual antibiotics) was demonstrated against 26 of 28 strains of A. calcoaceticus with carbenicillin plus kanamycin and carbenicillin plus tobramycin and against 25 of 28 strains with carbenicillin plus gentamicin. The median increased killing for the 28 strains was 4.2 log 10 with carbenicillin plus kanamycin and with carbenicillin plus tobramycin and 3.1 log 10 with carbenicillin plus gentamicin. The most important determinant of synergistic potential of each combination was the level of resistance of each strain of A. calcoaceticus to the aminoglycoside component of the combination.

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“…After G o u r e v it c h et al [4] had shown that at least no antagonism occurs between kanamycin and penicillin, several authors demonstrated, in vitro, that the combination of these antibiotics is synergistic against different bacterial species [1,2,[5][6][7][8]10]. In vivo, the advantage of combined therapy with penicillin and kanamycin was demonstrated by M o n t g o m er ie et al [9] in the experimental pyelonephritis provoked by Streptococcus faecalis in the rat.…”

Section: Introductionmentioning

confidence: 99%

Evidence for the <i>in vivo </i>Synergism between Penicillin and Kanamycin

Lambelin¹

1972

Chemotherapy

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The in vivo synergism between kanamycin and penicillin is investigated by comparing the antibacterial activity of plasma of rabbits treated i.m. with both antibiotics given alone or in a fixed combination. When studied as a function of time, the combination is statistically found synergistic against the S. aureus tested, 2 and 4 h after treatment. The synergism is also significantly demonstrated on 2 strains (S. aureus and E. coli) out of 3, when assays are undertaken 2 h after the i.m. administration of the antibiotics.

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The Action of Certain Antibiotics and Antibiotic Combinations Against Proteus Mirabilis With Demonstration of in Vitro Synergism and Antagonism

Cited by 16 publications

References 0 publications

The Use of Combinations of Antimicrobial Drugs

The Use of Combinations of Antimicrobial Drugs

In Vitro Synergism Between Carbenicillin and Aminoglycosidic Aminocyclitols Against Acinetobacter calcoaceticus var. anitratus

Evidence for the <i>in vivo </i>Synergism between Penicillin and Kanamycin

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