Evidence for the <i>in vivo </i>Synergism between Penicillin and Kanamycin

Abstract

The in vivo synergism between kanamycin and penicillin is investigated by comparing the antibacterial activity of plasma of rabbits treated i.m. with both antibiotics given alone or in a fixed combination. When studied as a function of time, the combination is statistically found synergistic against the S. aureus tested, 2 and 4 h after treatment. The synergism is also significantly demonstrated on 2 strains (S. aureus and E. coli) out of 3, when assays are undertaken 2 h after the i.m. administration of the antibiotics.