The absorption, metabolism, and excretion of xylenes in man

Šedivec, V.; Flek, J.

doi:10.1007/bf00378419

Cited by 99 publications

(63 citation statements)

References 10 publications

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“…However, toluene AFs from other studies were either much higher or much lower than the values reported here [41,42,45]. For C8-aromatics, while the mean respiratory AFs in many studies [29,46,49,50,[52][53][54] were lower than the 66.9% recorded in this study, other studies have reported much higher AFs [41,51]. Our results also indicated that the respiratory AFs of BTEX were much lower than 90%, which has been assumed to be the AF for toxic VOCs when assessing the human health risks of HAP exposure in many previous studies [6,[21][22][23][24]69].…”

Section: Preliminary Tests Of Real-time Afscontrasting

confidence: 73%

Real-time monitoring of respiratory absorption factors of volatile organic compounds in ambient air by proton transfer reaction time-of-flight mass spectrometry

Huang

Yan

Zhang

et al. 2016

Journal of Hazardous Materials

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Section: Preliminary Tests Of Real-time Afscontrasting

confidence: 73%

Real-time monitoring of respiratory absorption factors of volatile organic compounds in ambient air by proton transfer reaction time-of-flight mass spectrometry

Huang

Yan

Zhang

et al. 2016

Journal of Hazardous Materials

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“…These findings may suggest a dose-dependent influence of n-hexane and methylchloroform on cytochrome P-450, and they indicate the importance of the length of exposure. The inducing capacity of xylene may partly be due to the large uptake of xylene in comparison to the uptake of methylchloroform and aliphatic solvents (1,29). SDS-polya'Crylamide gel electrophoresis revealed that xylene induced RLvMc P-450 50 and RLvMc P-45 0 54 , which are the same cytochrome P-450 forms that are induced to the greatest extent by phenobarbital (31).…”

Section: Discussionmentioning

confidence: 99%

Changes in rat liver microsomal cytochrome P-450 and enzymatic activities after the inhalation of n-hexane, xylene, methyl ethyl ketone and methylchloroform for four weeks.

Toftgárd¹,

Nilsen²,

Gustafsson

1981

Scand J Work Environ Health

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Changes in rat liver microsomal cytochrome P-450 and enzymatic activities after the inhalation of n-hexane, xylene, methyl ethyl ketone and methylchloroform for four weeks. by Toftgård R, Nilsen OG, Gustafsson J-A Key terms: benzo(a)pyrene metabololism; enzymatic activity; induction; inhalation; methyl ethyl ketone; methylchloroform; microsomal cytochrome P-450; n-hexane; organic solvent; rat; rat liver; rat liver microsomal cytochrome P-450; steroid metabolism; xylene This article in PubMed: www.ncbi.nlm.nih.gov/pubmed/7313607Scand j work environ health 7 (1981) [31][32][33][34][35][36][37] Changes in rat liver microsomal cytochrome P-450 and enzymatic activities after the inhalation of n-hexane, xylene, methyl ethyl ketone and methylchloroform for four weeks by Rune Toftgard, SSe," 2 Odd G Nilsen, PhD,1.3 Jan-Ake Gustafsson MD, PhD 2 TOFTGARD R, NILSEN OG, GUSTAFSSON J-A. Changes in rat liver microsomal cytochrome P-450 and enzymatic activities afber the inhalation of n-hexane, xylene, methyl ethyl ketone and methylchloroform for :flour weeks. Scand j work environ health 7 (1981) 31-37. Groups of Sprague-Dawley rats were exposed, by inhalation, to n-hexane (900 ppm, 3,240 mg/m3), xylene (600 ppm, 2,625 mg/m:!), methy11 ethyl ketone (800 ppm, 2,345 mg/m3) and methylchlorofolm (800 ppm, 4,345 mg/m 3 ) :£or fuur weeks. Increased liver weights and liver to body weight ratios were observed~or all the ,solvents except n-hexane. An ,increased in Vlitro formati'on of certain metabolites of all the investigated substrates was found only illl the raits exposed to xylene. The in vitro microsomal metabolism of biphenyl, benzo(a)'PY'rene, 4-androstene-3,17-d~one and 5a-androstane3a, 17ji-diol in combination wHh sodium dodecyl sullfate-polyacrylamide gel electrophoresis showed that n-hexane was wi1!hout effect on rat liver microsomal cytochrome P-450 and that methyl ethyl ketone and mebhylc'hloroform depressed the formation of two metabolites of androstenedione but did not alter the concentration of cytochrome P-450 under the experimental e,onditions used. Xylene was shown to be a phenobarbital-like inducer of rat liver microsomal cytochrome P-450.

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“…There are no indications of reactive intermediates in these degradation processes. However, less than 2 % of the xylene and an even smaller fraction of the toluene retained in the human organism is hydroxylated at the aromatic nucleus (1,28). Thus, the possibility of an epoxide intermediate being formed in small amounts cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

Chromosome aberrations and sister chromatid exchanges in Swedish paint industry workers.

Haglund¹,

Lundberg²,

Zech³

1980

Scand J Work Environ Health

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The absorption, metabolism, and excretion of xylenes in man

Cited by 99 publications

References 10 publications

Real-time monitoring of respiratory absorption factors of volatile organic compounds in ambient air by proton transfer reaction time-of-flight mass spectrometry

Real-time monitoring of respiratory absorption factors of volatile organic compounds in ambient air by proton transfer reaction time-of-flight mass spectrometry

Changes in rat liver microsomal cytochrome P-450 and enzymatic activities after the inhalation of n-hexane, xylene, methyl ethyl ketone and methylchloroform for four weeks.

Chromosome aberrations and sister chromatid exchanges in Swedish paint industry workers.

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