Chromosome aberrations and sister chromatid exchanges in Swedish paint industry workers.

Haglund, Ulla; Lundberg, Ingvar; Zech, L.

doi:10.5271/sjweh.2606

Cited by 50 publications

(18 citation statements)

References 34 publications

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“…The significant increase in SCE associated with cigarette smoking alone has been noted by many other investigators [Soper et al, 1984; for review, see Ashby and Richardson, 19851 and is similar to previous results from in this laboratory [Kelsey et al, 19861. Our observation of no association between chronic solvent exposure and elevations in SCE frequency is consistent with that of Haglund et al [1980] who studied 17 industrial painters in Sweden. However, other workers who have studied solvent-exposed cohorts have noted that the combination of smoking and solvent exposure may be genotoxic.…”

Section: Discussionsupporting

confidence: 80%

“…Our results, and those of Haglund et al [1980], clearly indicate that chronic exposure to solvents in the painting trades does not induce SCE in peripheral blood lymphocytes. However, neither our estimate of solvent exposure nor that of Haglund et al [1980] accurately reflects exposure at the time of blood drawing.…”

Section: Discussionsupporting

confidence: 69%

“…In some cases, these studies have correlated well with the carcinogenicity of solvents, as assessed by epidemiologic methods [Purchase et al, 1978;Fredga et al, 1979Fredga et al, , 1982Sorsa et al, 1983;Maki-Paakkanen et al, 19841. Other studies have produced conflicting data, indicating that some of these exposures may not be genotoxic [Haglund et al, 1980;Mitelman et al, 1980;Suskov and Sazonova, 1982;Sazonova and Suskov, 19851. Therefore, the current study of IBPAT members was initiated to investigate further the genotoxicity of the complex solvent exposures encountered by members of this trade.…”

Section: Introductionmentioning

confidence: 99%

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Effects of cigarette smoking and solvent exposure on sister chromatid exchange frequency in painters

Kelsey

Wiencke

Little

et al. 1988

Environ and Mol Mutagen

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A cross-sectional study of sister chromatid exchange frequency (SCE) in peripheral blood lymphocytes from 117 members of the International Brotherhood of Painters and Allied Tradesman was conducted in union locals in two major U.S. cities. Chronic solvent exposure intensity and duration were estimated from interviewer-administered-questionnaire data. SCE for all of the workers in the study were scored by one reader. A second reader determined the SCE frequency from a random sample of 30 workers. No significant difference in SCE frequency was associated with reader or time of reading. Age, coffee and alcohol intake and chronic solvent exposure (both intensity and duration, estimated over the working lifetime and over the year prior to study for each worker) did not significantly elevate SCE. The effect of smoking on SCE frequency, assessed by analysis of variance controlling for other possible confounding factors, showed that smoking increased SCE frequency (P less than .0001). The SCE frequency in the smoking, solvent-exposed (estimated as lifetime exposure) painters was 6.75 SCE/cell; in the non-smoking, solvent-exposed workers the SCE frequency was 5.73 SCE/cell; the controls had SCE levels of 6.84 SCE/cell (smokers) and 5.90 SCE/cell (non-smokers), respectively. These observations are consistent with other work suggesting that chronic solvent exposure in the paint trade is not associated with an elevation in SCE in peripheral blood lymphocytes. However, further work is necessary to address adequately the question of the genotoxicity of acute solvent exposure in these workers.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

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Effects of cigarette smoking and solvent exposure on sister chromatid exchange frequency in painters

Kelsey

Wiencke

Little

et al. 1988

Environ and Mol Mutagen

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“…In studies of persons exposed occupationally to toluene, most authors found no clear differences in the incidence of sister chromatid exchange (SCE) or other chromosomal changes in the exposed and control groups (Forni et al 1971, Haglund et al 1980, Holmen et al 1988, Mäki-Paakkanen et al 1980, Richer et al 1993). Slight differences (slight increases in chromosome breaks and SCE) were put down to "unknown environmental effects" (Funes-Cravioto et al 1977) or to contamination of the toluene with benzene (slight increase in the incidence of dicentric chromosomes without a change in the incidence of chromatid aberrations or SCE in 31 printing works employees) (Carbonell et al 1982).…”

Section: Genotoxicitymentioning

confidence: 99%

Toluene [MAK Value Documentation, 1996]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 7 (1996) The article contains sections titled: Recent Reviews Toxic Effects and Modes of Action Uptake, Biotransformation and Excretion Effects in Man Single exposures Repeated exposures Effects on skin and mucous membranes Reproductive and developmental toxicity Genotoxicity Effects on Animals Acute inhalation toxicity Subchronic and chronic inhalation toxicity Effects on skin and mucous membranes Reproductive and developmental toxicity Genotoxicity Carcinogenicity Manifesto (MAK value, classification)

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“…In a group of 117 painters, no significant increase in sister chromatid exchange frequency was found (6). In addition, in a group of Swedish paint industry workers, Haglund et a1 (7) did not find a significant increase in sister chromatid exchanges or chromosome aberrations. Results of a cytogenetic analysis carried out Reprint requests to: Dr J Fuchs, Institute of Toxicology, University of Mainz, Obere Zahlbacherstrasse 67, D-55131 Mainz, Germany.…”

mentioning

confidence: 91%