Transient increase in DNA strand breaks in car refinishing spray painters

Fuchs, Jürgen; Hengstler, Jan G.; Hummrich, Frank; Oesch, Franz

doi:10.5271/sjweh.165

Cited by 10 publications

(5 citation statements)

References 17 publications

(19 reference statements)

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“…Increased frequencies of micronuclei (MNs) in lymphocytes and in buccal epithelial cells were observed among paint industry workers. Similar considerations were made by (Silva and Santos-Mello 1996), who observed increased proportions of aneuploid lymphocytes and chromosome deletions in car painters and also by (Fuchs et al 1996), who reported a transient increase in DNA strand breaks in car spray painters. Painters in India mostly use commercially available paints of high lead content and occasionally gasoline or thinner as solvents.…”

Section: Background Aim and Scopementioning

confidence: 51%

Elevated blood lead levels and cytogenetic markers in buccal epithelial cells of painters in India

Khan

Ahmad

Mahdi³

et al. 2010

Environ Sci Pollut Res

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The use of lead in paints is completely unregulated in India and routine surveillance of paints for lead content is still lacking. These paints are readily available in markets and are also used in other products (jewelry, miniblinds) which could be exported to other countries including United States and Europe. Serious consideration should be given to the inclusion of regulations and bans on the use of lead in paints. Moreover, attention should also be paid towards the use of various protective measures (face-masks, hand gloves, and separate clothes) by the workers as safe work practices during working periods.

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Section: Background Aim and Scopementioning

confidence: 51%

Elevated blood lead levels and cytogenetic markers in buccal epithelial cells of painters in India

Khan

Ahmad

Mahdi³

et al. 2010

Environ Sci Pollut Res

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“…The authors suggested that dermal exposure may be the major contributor to the total body burden of solvents found in spray painters not wearing protective suits and gloves. Moreover, Fuchs et al (1996) demonstrated that the use of safety equipment, such as masks and spray booths, seems to affect DNA damage repair only marginally in spray painters of auto body shops. Therefore, in our study, it is possible to speculate that dermal exposure played a role in genotoxicity findings, because protective clothing and gloves were rarely or never worn by the workers assessed.…”

Section: Discussionmentioning

confidence: 99%

Genotoxic damage in auto body shop workers

Siebel

Silva

2010

Toxicol Ind Health

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Some studies have shown increased DNA damage among car painters, but other professionals working in auto body and paint shops have not been extensively assessed. The aim of this study was to assess DNA damage in different types of auto body shop workers by measuring micronucleus (MN) levels in exfoliated buccal cells. The mean number of cells with MN per 2000 exfoliated buccal cells was analyzed in three groups of male workers: auto body repair technicians, painters, and office workers (control group). All participants answered a questionnaire inquiring about age, smoking habits, alcohol consumption, work practices, occupational exposure time, job activities, and use of protective equipment. The mean number of cells with MN was 3.50 ± 1.50 in auto body painters, 3.91 ± 2.10 in auto body repair technicians, and 0.80 ± 0.78 in office workers, with a significant difference between the control group and the two other groups (p = 0.0001). Age, occupational exposure time, use of protective masks, alcohol consumption, and smoking habit did not affect MN results. The findings indicate that technicians and painters working in auto body shops are at risk for genotoxic damage, while office workers seem to be protected.

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“…The small number of workers in each shop is common for this type of work environment in Italy. Most of the available cytogenetic studies indicate that spray painters are at risk of genotoxic exposure [PinaCalva et al, 1991;Pinto et al, 1991;Fuchs et al, 1996;Silva and Santos-Mell 1996], but, because of the complex paint composition, it is difficult to relate this observed risk to each paint component. In our study, the diversity of tasks performed by the workers made it difficult to quantitatively associate particular exposures with the biological responses.…”

Section: Discussionmentioning

confidence: 99%

“…A significant increase in chromosomal aberrations (CAs), in particular, deletions and aneuploidy, was found in a group of car painters [Silva and Santos-Mell, 1996]. Similarly, others have found a significant increase in CAs in a cohort of underground railroad car painters [Pina-Calva et al, 1991], and an increase in DNA strand breaks in a group of carrefinishing spray painters [Fuchs et al, 1996]. In a study of outdoor painters, cytogenetic damage was associated with the time of occupational exposure [Pinto et al, 2000].…”

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confidence: 95%

A multi‐biomarker analysis of DNA damage in automobile painters

Testa

Festa

Ranaldi

et al. 2005

Environ and Mol Mutagen

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The genotoxic effects associated with automobile painting were analyzed using a panel of biomarkers. Chromosomal aberrations (CAs), sister chromatid exchange (SCE), and micronuclei were evaluated in 25 car painters (12 smokers, 13 nonsmokers) working in different automobile paint-shops in Italy and in 37 control subjects. The controls were healthy blood donors (14 smokers, 23 non-smokers) that were matched with the experimental population for gender and age. Air samples were analyzed regularly at the work places, and elevated concentrations of benzene and toluene were detected consistently. The exposed group had higher frequencies of CAs (both chromosome- and chromatid-type), micronuclei, and SCE (P < 0.5 - P < 0.001). Furthermore, exposed and control subjects were also genotyped for GSTM1 and GSTT1 polymorphism. No significant associations were detected between the biomarker responses and either the GSTM1 or GSTT1 genotype of the subjects, but the small sample size does not allow definite conclusions on the relationship between the genetic polymorphism and the biomarkers. The results indicate that automobile painters have increased levels of clastogenic and possible aneugenic damage and that smoking may be a confounding factor for the responses.

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Transient increase in DNA strand breaks in car refinishing spray painters

Cited by 10 publications

References 17 publications

Elevated blood lead levels and cytogenetic markers in buccal epithelial cells of painters in India

Elevated blood lead levels and cytogenetic markers in buccal epithelial cells of painters in India

Genotoxic damage in auto body shop workers

A multi‐biomarker analysis of DNA damage in automobile painters

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