The absolute stereochemistries of (+)-toddalolactone and its related chiral coumarins from Toddalia asiatica(L.) Lam. (T. aculeata Pers.) and their optical purities

Antiplasmodial and larvicidal compounds of Toddalia asiatica root bark

“…The isolates were identified using spectroscopic methods (UV, IR, 1 H and 13 C NMR, and MS) as well as comparison with already documented literature. 6,12,[17][18][19][20][21] 4.2 Larvicidal activity of crude extracts and pure isolates from T. asiatica against Aedes egypti n-Hexane, ethyl acetate and methanol extracts and isolated compounds from the root bark were tested for their potency against mosquito larvae and the result are as shown in table 3. The n-hexane extract showed the best activity with LC 50 value of 9.4 ± 1.0 μg/ml after 48 h exposure as compared to ethyl acetate 13.8 ± 3.5 μg/ml and methanol 50.1 ± 3.0 μg/ml after the same exposure duration.…”

Chemical Investigation and Antimicrobial Activity of Medicinal Plant <i>Toddalia asiatica</i> Lam

“…Toddalia asiatica Lam is a well-recognized medicinal plant in India, China, East Africa, Europe, and Okinawa [1][2][3][4]. Three main parts of this plant; fruits, roots, and leaves have been used to cure the same diseases like malaria, coughs, influenza, lung disease, rheumatisms, bronchial pains, stomachache, snake bites [1,5].…”

“…This part describes the isolation, structure elucidation, and bioactivities of the four new coumarins class 1-4 together with five known compounds, toddalo lactone (5), toddaculin (6), toddanol (7), dihydrochelery thrine (8), and 6-Acetonyldihydrochelerythrine (9) from the medicinal plant T. asiatica [4,6,15,26].…”

Cytotoxic Coumarins from Toddalia asiatica

“…In this paper, three new coumarins 1-3 together with 13 known compounds were isolated from the crude EtOAc extract of T. asiatica bark. Thirteen known compounds included 4-O-geranylconiferyl aldehyde (4) [12], nelumol A (5) [13], phellopterin (6) [14], 5-methoxy-8-geranyloxylpsoralen (7) [15], artanin (8) [16], 8geranyloxy-5,7-dimethyloxycoumarin (9) [16], 5,7,8-trimethoxycoumarin (10) [16], leptodactylone (11) [17], toddalolactone (12) [18], toddalolactone methyl ether (13) [19], 1,2-secodihydromethylumbelliferone methyl ester (14) [20], toddalosin (15) [16], and norchelerythrine (16) [21] were discovered (l " Fig. 1).…”