Antiplasmodial and larvicidal compounds of Toddalia asiatica root bark

Abstract

From the n-hexane, ethyl acetate and methanol extracts of Toddalia asiatica root bark were isolated eight compounds (1-8) which were identified on the basis of both spectroscopic and physical data as well as comparison with already published results. The crude extracts and isolated compounds showed moderate in vitro antiplasmodial activity against D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum. The extracts and isolates also exhibited larvicidal activities against Aedes aegypti and coumarins were identified as the active compounds.

Separation of New Coumarin Glycosides from Toddalia asiatica Using Offline Two-Dimensional High-Performance Liquid Chromatography

“…The roots and barks of T. asiatica have been used in Miao minority medicine, mainly in Guizhou, Yunnan, and Guangxi provinces in China, for the treatment of fall injuries, rheumatic arthralgia, stomachache, chronic lumbago, and diarrhea [3,4]. Previous phytochemical and pharmacological investigations of different parts of this plant revealed that coumarins are the main secondary metabolites [5], some of which exhibited cytotoxic, antimalarial [6], antiviral [7], anti-inflammatory [8], antibacterial [9], anti-platelet aggregation [10], anti-plasmodial, larvicidal [11], phosphodiesterase-4 inhibitory [12], and osteoclastogenesis activities [13]. Even though coumarins are rather studied, less attention has been paid to their glycosides.…”

Bioefficacy of flindersine against Helicoverpa armigera Hübner, Spodoptera litura Fabricius, Anopheles stephensis Liston. and Culex quinquefasciatus Say.

“…The Kani tribes use the extract of this plant to cure skin diseases (Ayyanar and Ignacimuthu 2005). The extracts of this plant exhibited strong insecticidal properties against Aedes aegypti Linnaeus, A. albopictus Skuse and Culex quinquefasciatus Say (Borah et al 2010;Liu et al 2013;Nyahanga et al 2013); and larvicidal and antifeedant properties against Helicoverpa armigera Hübner ( Sundararajan and Kumuthakalavalli 2001;Ramya et al 2009). H. armigera is a polyphagous pest causing serious damage to many agricultural and horticultural crops such as cotton, tomato, brinjal, chickpea, pigeonpea, chilli, maize, and sorghum (Manjunath et al 1989;Talekar et al 2006).…”

Toddalia aculeata: A comprehensive review of its Phytochemistry, pharmacology and its traditional use

“…Isolated compounds from T. asiatica showed the highest level of larvicidal activity. Toddalia asiatica exhibited strong larvicidal effects against Aedes aegypti due to presence of sibricin and coumarins compounds [45]. Aqueous extract of Toddalia asiatica Lam.…”