The ability of selected plant essential oils to enhance the action of recommended antibiotics against pathogenic wound bacteria

Sienkiewicz, Monika; Łysakowska, Monika; Kowalczyk, Edward; Szymańska, Grażyna; Kochan, Ewa; Krukowska, Jolanta; Olszewski, Jurek; Zielińska‐Bliźniewska, Hanna

doi:10.1016/j.burns.2016.08.032

Cited by 37 publications

(25 citation statements)

References 14 publications

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“…This might be useful for the rapid healing of acute wounds through protection of the injury site from infections and inhibition of the inflammatory cells as well as by increasing the connective tissue formation in the repaired tissues. Similar findings were confirmed [2,3,[21][22][23]31].…”

Section: Wound Healing Activity Of Ch Teo and Ch-teo MIXsupporting

confidence: 85%

“…The former authors pointed that thymol as main component of TEO have bactericidal effect and can have helpful effects in regulating the inflammatory mechanism which is required for appropriate wound healing. Since inflammation causes many difficulties including infection, wound dehiscence and impaired collagen synthesis, antiinflammatory effects of thymol would be promising material when thyme essential oil is used [15,[21][22][23]. The commonly antimicrobial activity mechanism is considered as resulted by disturbing the function of the cytoplasmic membrane, disrupting the active transport of nutrients to the cell membrane, and coagulation of bacterial cell contents [16,24].…”

Section: Resultsmentioning

confidence: 99%

“…The TEO might possibly encourage the healing process at the initial steps of wound healing by acting as antimicrobial components [22]. In previous study of Süntar et al [27] confirmed that wound healing and anti-inflammatory activities of olive oil extract of H. perforatum and its fractions exerted a significant effect on excision and incision wound models with a dose-dependent activity.…”

Section: Wound Healing Activity Of Ch Teo and Ch-teo MIXmentioning

confidence: 92%

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Synergistic Effect of Thymus vulgaris Essential Oil Oral Administration on Topically Treated Wound with Chitosan, Thyme Essential Oil and their Combination in Rats

Barakat¹,

Aljabeili²,

Abdel-Rahman³

2018

J Nutr Food Sci

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Herbal medication from natural resources plays an important role as antioxidant, antibacterial agent and demonstrating an inimitable property in wound curative rather than synthesized-toxic materials. The present investigation was designed to evaluate the potential healing efficacy of thyme (Thymus vulgaris) essential oil (TEO) oral adminstartion on topically treated wound with chitosan, TEO and their combination in vitro. Practically, effect of TEO oral administration on topically treated wounded rats in comparing to topical application of betadine for two weeks was carried out. Remarkably, treated group with TEO topically and orally exhibited the highest wound contractions among all treated groups. In Parallel, histopathological alteration was improved in TEO topically and orally applications whereas no degeneration, necrosis & inflammatory cells infiltration in skeletal muscle of wound with rejuvenation of hair follicles were observed. Wound healing efficiency was established in vivo and recommended as natural agent for wounds through protection of injury site from infections and inhibition of inflammatory cells as well as increasing connective tissue formation in repaired tissues. These favored results confirm that treated group with TEO topically combined with TEO orally have outstanding wound healing activity and need exploitation as an alternative source of natural wound agents for medical applications.

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Section: Wound Healing Activity Of Ch Teo and Ch-teo MIXsupporting

confidence: 85%

Section: Resultsmentioning

confidence: 99%

Section: Wound Healing Activity Of Ch Teo and Ch-teo MIXmentioning

confidence: 92%

See 1 more Smart Citation

Synergistic Effect of Thymus vulgaris Essential Oil Oral Administration on Topically Treated Wound with Chitosan, Thyme Essential Oil and their Combination in Rats

Barakat¹,

Aljabeili²,

Abdel-Rahman³

2018

J Nutr Food Sci

View full text Add to dashboard Cite

show abstract

“…Besides its antioxidant activity, antibacterial, antifungal, and antiinflammatory properties have been reported for plant‐derived essential oils, including rosemary essential oil, which made those oils attractive for topical application (Lang & Buchbauer, ; Liakos et al, ; Liakos, Holban, Carzino, Lauciello, & Grumezescu, ; Raut & Karuppayil, ; Sienkiewicz et al, ). Tawab, El‐Hofy, Mobarez, Taha, and Tawkol () demonstrate a synergic interaction between rosemary with antimicrobial agents against Staphylococcus aureus in vitro .…”

Section: Rosmarinus Officinalis Lmentioning

confidence: 99%

“…In addition, the wounds completely healed on day 25 in rats treated with creams containing P. granatum flower extract compared with other groups, indicating that pomegranate flower extract promoted wound healing in rats and could be used for managing burn injuries (Nasiri & Hosseinimehr, 2017). Besides its antioxidant activity, antibacterial, antifungal, and antiinflammatory properties have been reported for plant-derived essential oils, including rosemary essential oil, which made those oils attractive for topical application (Lang & Buchbauer, 2012;Liakos et al, 2014;Liakos, Holban, Carzino, Lauciello, & Grumezescu, 2017;Raut & Karuppayil, 2014;Sienkiewicz et al, 2017). Tawab, El-Hofy, Mobarez, Taha, and Tawkol (2015) demonstrate a synergic interaction between rosemary with antimicrobial agents against Staphylococcus aureus in vitro.…”

Section: Punica Granatum Lmentioning

confidence: 99%

Natural actives for wound healing: A review

Ataide

Cefali

Croisfelt

et al. 2018

Phytotherapy Research

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Nature has been a source of medicinal treatments for thousands of years, with the use of plants as prototypes for drug development and for the extraction of active compounds. Skin injuries occur regularly in everyday life, and the human skin has the ability to promote repair spontaneously under healthy conditions. However, some intrinsic and external factors may interfere with skins' natural ability, leading to nonhealing lesions and chronic wounds, which directly affect health and quality of life. Thus, attention should be given to this health problem, using an appropriated management when necessary. In this scenario, phytotherapy may be an option for cutaneous wound treatment, although further high-quality studies are needed to firmly establish the clinical efficacy of plants. This article reviews traditionally used natural actives for wound healing, highlighting their characteristics and mode of action.

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3D‐printed β‐TCP/S53P4 bioactive glass scaffolds coated with tea tree oil: Coating optimization, in vitro bioactivity and antibacterial properties

et al. 2022

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Bone infection treatment is a significant challenge for the orthopedic field. 3D printing is a promising technology to produce scaffolds with customized architecture, able to stimulate and support bone growth. β-TCP and S53P4 bioactive glass (BG) are well-known biomaterials for scaffold manufacturing. However, a multifunctional scaffold, able to inhibit microbial proliferation at the defect site, is of increasing interest to avoid infection recurrence. Tea tree oil (TTO) has aroused interest as an antimicrobial agent to minimize the use of antibiotics. Therefore, combining the regenerative potential of a bioceramic with TTO's antimicrobial properties could result in a scaffold capable of stimulating tissue growth and treating infections. In this context, this study aimed to produce and characterize 3D-printed β-TCP/S53P4 BG scaffolds coated with TTO. Scaffolds morphological and chemical characterizations were carried out through XDR, SEM, and FTIR analysis. β-TCP/S53P4 BG scaffolds showed a compressive strength of $2 MPa and 53 ± 2% of porosity. The scaffolds were coated by two different procedures, using an ethanol/TTO (EtOH/TTO) and a gelatin/TTO (Gel/TTO) solution with 5, 10, and 15% (v/v) TTO. The addition of TTO decreased MG-63 cell viability for both coating groups, but the Gel/TTO group showed higher cell viability. The antibacterial activity of the coated scaffolds was evaluated against S. aureus and higher inhibition of colony formation was found for Gel/TTO group.Therefore, the coating with Gel/TTO was effective in terms of antibacterial activity and cell viability. Such Gel/TTO coated β-TCP/S53P4 BG scaffolds are proposed for antibacterial bone tissue engineering.

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The ability of selected plant essential oils to enhance the action of recommended antibiotics against pathogenic wound bacteria

Cited by 37 publications

References 14 publications

Synergistic Effect of Thymus vulgaris Essential Oil Oral Administration on Topically Treated Wound with Chitosan, Thyme Essential Oil and their Combination in Rats

Synergistic Effect of Thymus vulgaris Essential Oil Oral Administration on Topically Treated Wound with Chitosan, Thyme Essential Oil and their Combination in Rats

Natural actives for wound healing: A review

3D‐printed β‐TCP/S53P4 bioactive glass scaffolds coated with tea tree oil: Coating optimization, in vitro bioactivity and antibacterial properties

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