The A Body Shape Index Might Be a Stronger Predictor of Chronic Kidney Disease Than BMI in a Senior Population

Kim, Bokun; Kim, Gwon-Min; Kim, Eonho; Park, Jong Hwan; Isobe, Takeshi; Sakae, Takeji; Oh, Sang‐Ha

doi:10.3390/ijerph182412874

Cited by 13 publications

(21 citation statements)

References 42 publications

(57 reference statements)

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“…A prospective population-based longitudinal analysis conducted in Japan reported an association between high VAI and lower baseline eGFR [ 39 ]. Another study reported an association between high LAP and VAI with lower baseline eGFR in adults without DM [ 40 ], and Kim et al found a negative association between ABSI and eGFR in a cohort of older adults [ 41 ]. In the study by Ou et al, high AVI, BMI, BRI, CI, LAP, WHR, WHtR, and VAI were significantly associated with advanced CKD (eGFR < 30 mL/min/1.73 m 2 ) in patients with type 2 DM, whereas BAI and ABSI were not [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome and Obesity-Related Indices Are Associated with Rapid Renal Function Decline in a Large Taiwanese Population Follow-Up Study

Chen²,

Wu³

et al. 2022

Biomedicines

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A rapid decline in renal function can cause many complications, and therefore it is important to detect associated risk factors. Few studies have evaluated the associations among obesity-related indices and metabolic syndrome (MetS) with renal function decline. This longitudinal study aimed to explore these relationships in a large cohort of Taiwanese participants. The studied obesity-related indices were waist-to-height ratio (WHtR), A body shape index (ABSI), visceral adiposity index (VAI), lipid accumulation product (LAP), waist-to-hip ratio (WHR), body roundness index (BRI), conicity index (CI), body mass index (BMI), body adiposity index (BAI) and abdominal volume index (AVI). We included 122,068 participants in the baseline study, of whom 27,033 were followed for a median of four years. The baseline prevalence of MetS was 17.7%. Multivariable analysis showed that the participants with MetS and high VAI, WHtR, WHR, LAP, CI, BRI, BMI, BAI, AVI, and ABSI values were significantly associated with a high baseline estimated glomerular filtration rate (eGFR) (all p < 0.001). In addition, the participants with MetS (p < 0.001), high WHtR (p = 0.007), low LAP (p < 0.001), high BRI (p = 0.002), high CI (p = 0.002), high AVI (p = 0.001), high VAI (p = 0.017), and high ABSI (p = 0.013) were significantly associated with a low △eGFR, indicating a rapid decline in renal function. These results showed associations between MetS and high values of obesity-related indices except LAP with high baseline eGFR and rapid decline in kidney function. These findings suggest that screening for MetS and obesity may help to slow the decline in renal function in high-risk populations.

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Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome and Obesity-Related Indices Are Associated with Rapid Renal Function Decline in a Large Taiwanese Population Follow-Up Study

Chen²,

Wu³

et al. 2022

Biomedicines

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“…The BMI was calculated as body mass (kg)/height (m 2 ), and the VAI as (WC/(36.58 + (1.89 × BMI)) × ((TG/0.81) × (1.52/HDLC)) for women and (WC/(39.68 + (1.88 × BMI)) × ((TG/1.03) × (1.31/HDLC)) for men [ 21 ]. The BMI and VAI were converted into Z-scores using the following equation: (individual value − mean value)/standard deviation (SD) [ 29 , 30 ]. The ability of the two body adiposity indices to predict CKD was then analyzed.…”

Section: Methodsmentioning

confidence: 99%

“…The eGFR was defined in accordance with the Japanese version of the Modification of Diet in Renal Disease study equation: eGFR (mL/min/1.73 m 2 ) = 194 × serum creatinine −1.094 × age −0.287 × 0.739 (for women) [ 19 , 28 , 30 , 31 ]. The subjects were divided into three groups on the basis of eGFR tertile: normal (N) group, eGFR ≥ 60.0 mL/min/1.73 m 2 ; mild CKD ( M CKD) group, eGFR = 45.0–59.9 mL/min/1.73 m 2 ; and moderate-to-severe CKD ( MS CKD) group, eGFR < 45.0 mL/min/1.73 m 2 [ 19 , 29 , 31 , 32 ].…”

Section: Methodsmentioning

confidence: 99%

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Use of the Visceral Adiposity Index as an Indicator of Chronic Kidney Disease in Older Adults: Comparison with Body Mass Index

Kim

Oh³

2022

JCM

Self Cite

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The visceral adiposity index (VAI) was recently introduced to quantify visceral fat accumulation and dysfunction. This cross-sectional study explored whether the VAI is associated with chronic kidney disease (CKD) in older adults and compared its utility with that of body mass index (BMI) for predicting CKD. In total, 7736 older adults (3479 men and 4257 women) aged ≥ 60 years were divided into normal, mild, and moderate-to-severe CKD groups. Associations of the VAI and BMI with CKD were compared among the groups, and cut-off points for moderate-to-severe CKD (MSCKD) were established. While the VAI could discriminate among all of the groups, the BMI could not. The severity of CKD was more strongly associated with the VAI than BMI. The odds ratios indicated that, in the fully adjusted model, the VAI was a significant predictor of MSCKD in both men and women, while the BMI was a significant predictor only in men. For the VAI, the area under the receiver operating characteristic curve values for men and women were 0.631 (cut-off point: ≥2.993) and 0.588 (≥4.001), compared with 0.555 (≥25.335) and 0.533 (≥24.096) for BMI, respectively. Taken together, the findings suggest that the VAI is associated with CKD and represents a better indicator for the disease than BMI.

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“…pt?>A cohort study of 5,438 urban residents in Japan found that ABSI can predict subjects at risk of renal function decline more effectively than WC ( 10 ). A cross-sectional survey of 7,053 older people in South Korea showed that the ABSI had a better capacity to discriminate the CKD stage than BMI ( 11 ). However, to our knowledge, evidence of the relationship between ABSI and UACR in the large-sample population is lacking.…”

Section: Introductionmentioning

confidence: 99%

The association between a body shape index and elevated urinary albumin–creatinine ratio in Chinese community adults

Zhang

Gao

et al. 2022

Front. Endocrinol.

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BackgroundObesity, especially visceral obesity, seems to be one of the most decisive risk factors for chronic kidney disease. A Body Shape Index (ABSI) is an emerging body size measurement marker of visceral obesity. This study aimed to explore whether ABSI is associated with albuminuria in Chinese community adults.MethodsThis cross-sectional study enrolled 40,726 participants aged 40 or older from seven provinces across China through a cluster random sampling method. ABSI was calculated by body mass index, waist circumference, and height. Increased albuminuria was defined as urinary albumin–creatinine ratio (UACR) ≥ 30 mg/g, indicating kidney injury. For ABSI, we divided it by quartile cutoff points and tried to determine the association between ABSI levels and UACR by multiple regression analysis. DAG (Directed Acyclic Graph) was plotted using literature and expert consensus to identify potential confounding factors.ResultsThe average age of subjects with elevated UACR was 61.43 ± 10.07, and 26% were men. The average age of subjects with normal UACR was 57.70 ± 9.02, and 30.5% were men. Multiple logistic regression analysis was conducted and demonstrated that the ABSI quartiles were related to elevated UACR positively (OR [95% CI] Q2 vs. Q1: 1.094 [1.004, 1.197]; OR [95% CI] Q3 vs. Q1: 1.126 [1.030, 1.231]; OR [95% CI] Q4 vs. Q1: 1.183 [1.080, 1.295], p for trend < 0.001) after adjustments for confounding factors. The stratified analysis further showed that with the mounting for ABSI levels, elevated UACR more easily occurred in the people characterized by the elderly, men, and hypertension.ConclusionsIn Chinese community adults, people with higher ABSI levels can be deemed as high-risk individuals with UACR elevation, and it will be beneficial for them to lose weight and significantly reduce visceral fat.

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The A Body Shape Index Might Be a Stronger Predictor of Chronic Kidney Disease Than BMI in a Senior Population

Cited by 13 publications

References 42 publications

Metabolic Syndrome and Obesity-Related Indices Are Associated with Rapid Renal Function Decline in a Large Taiwanese Population Follow-Up Study

Metabolic Syndrome and Obesity-Related Indices Are Associated with Rapid Renal Function Decline in a Large Taiwanese Population Follow-Up Study

Use of the Visceral Adiposity Index as an Indicator of Chronic Kidney Disease in Older Adults: Comparison with Body Mass Index

The association between a body shape index and elevated urinary albumin–creatinine ratio in Chinese community adults

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