Use of the Visceral Adiposity Index as an Indicator of Chronic Kidney Disease in Older Adults: Comparison with Body Mass Index

Kim, Bokun; Kim, Gwon-Min; Oh, Sang‐Ha

doi:10.3390/jcm11216297

Cited by 7 publications

(6 citation statements)

References 46 publications

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“…VAI also plays an important value in predicting the development of end-stage renal disease in patients with type 2 diabetes [ 27 , 28 ]. Kim et al found that visceral fat accumulation could be a better predictor of CKD severity than BMI, regardless of the patient's gender [ 29 ]. Another study in Korean adults showed a positive association of VAI with CKD incidence in men only, and this association was no longer significant in women [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

The association of visceral adiposity index with the risk of kidney stone and kidney stone recurrence

Liang,

Liu,

Yang

2023

BMC Nephrol

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Aim Our aim in this study was primarily to assess the relationship between visceral adiposity index (VAI) and the risk of kidney stones and kidney stone recurrence in US adults. Methods We used data from the National Health and Nutrition Examination Survey (NHANES) 2007–2014 for our analysis. VAI was calculated from waist circumference (WC), body mass index (BMI), triglycerides (TG), and high-density lipoprotein-cholesterol (HDL-C). Kidney stones and recurrence of kidney stones were obtained from questionnaire interview data. We used multivariate logistic regression analysis to explore the correlation between VAI and the risk of kidney stone and kidney stone recurrence. In addition, we performed subgroup analysis, interaction tests, and restricted cubic spline (RCS) analysis. Results A total of 9886 participants were included in this study, with a prevalence of 9.24% for kidney stones and 2.97% for recurrence of kidney stones. The prevalence of kidney stones and kidney stone recurrence increased with higher quartiles of VAI. We observed a significantly positive correlation between VAI and the risk of kidney stone and kidney stone recurrence. Participants with the highest VAI quartiles had a 48% (OR: 1.48, 95%CI: 1.08–2.02) and 52% (OR: 1.52, 95%CI: 0.86–2.71) increased risk of kidney stones and kidney stone recurrence, respectively, compared to participants with the lowest VAI quartiles. Subgroup analysis and interaction tests demonstrated this positive association independent of different subgroup factors. Conclusion Visceral fat accumulation may be associated with an increased risk of kidney stones and kidney stone recurrence.

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Section: Discussionmentioning

confidence: 99%

The association of visceral adiposity index with the risk of kidney stone and kidney stone recurrence

Liang,

Liu,

Yang

2023

BMC Nephrol

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“…The Mann–Whitney U test was used for non-normally distributed data that were verified by utilizing Levene’s test for equality of variances. The Jonckheere–Terpstra test was used to identify trends in parameters among the three groups (two-tailed) [ 29 , 30 , 31 , 32 , 33 ]. This test generated standardized statistics that represented the strength of trends in parameters that increased or decreased across groups [ 29 , 30 , 31 , 32 , 33 ].…”

Section: Methodsmentioning

confidence: 99%

“…The Jonckheere–Terpstra test was used to identify trends in parameters among the three groups (two-tailed) [ 29 , 30 , 31 , 32 , 33 ]. This test generated standardized statistics that represented the strength of trends in parameters that increased or decreased across groups [ 29 , 30 , 31 , 32 , 33 ]. Logistic regression was employed to evaluate the relationships of the TyG index, which was an independent parameter, with obesity, sarcopenia, and sarcopenic obesity, which were dependent parameters.…”

Section: Methodsmentioning

confidence: 99%

Triglyceride–Glucose Index as a Potential Indicator of Sarcopenic Obesity in Older People

Kim

Lee

et al. 2023

Nutrients

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Purpose: This population-based cross-sectional study aimed to determine whether the triglyceride–glucose index (TyG index) is associated with sarcopenic obesity (SO) and whether it would be a helpful indicator of SO. Methods: A total of 3821 participants aged ≥60 years were selected for the study group, and 4919 participants aged 20–39 years were included as a reference group. The participants were allocated to sarcopenia, obesity, and SO groups depending on if their body mass index (BMI) was ≥25 kg/m2 and their sarcopenia index was ≤1 standard deviation (SD) lower than the mean of the reference group. The sex-specific differences and trends among the participants were analyzed by using the TyG index tertiles, and appropriate cut-off values of the TyG index for SO were calculated. Results: As the TyG index increased, BMI increased, but the sarcopenia index decreased in both sexes. Males and females in the middle and highest tertiles of the TyG index were 1.775 and 3.369, and they were 1.993 and 3.157 times more likely to have SO, respectively. The cut-off values of the TyG index for SO in males and females were ≥8.72 and 8.67, respectively. Conclusion: A high TyG index is positively associated with SO, and the TyG index may be considered a potential indicator of SO.

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“…The estimated glomerular filtration rate (eGFR) was calculated using the new Japanese-coefficient modified MDRD (Modification of Diet in Renal Disease) study equation as follows. 8,9,[23][24][25] eGFR (mL/min/1.73 m 2 ) = 194 × (serum creatinine) −1.094 × (age) −0.287 ( × 0.739 for females).…”

Section: Study Design and Subjectsmentioning

confidence: 99%

The Triglyceride-Glucose Index is Independently Associated with Chronic Kidney Disease in the Geriatric Population, Regardless of Obesity and Sex

Kim,

Han

et al. 2023

Ann Geriatr Med Res

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Background: Insulin resistance (IR) negatively affects several risk factors of chronic kidney disease (CKD). This cross-sectional study investigated whether the triglyceride-glucose (TyG) index, which reflects IR, was independently associated with CKD in a geriatric population, regardless of obesity and sex. Methods: The analysis included 7,326 individuals (2,864 males and 4,462 females) aged ≥60 years. Non-obesity or obesity was evaluated using a body mass index cutoff of 25 kg/m2. The TyG index was calculated as ln [triglyceride concentration (mg/dL)×fasting plasma glucose concentration (mg/dL)]/2. All participants were categorized into three groups according to TyG tertiles. Moderate-to-severe CKD (MSCKD) was defined as an estimated glomerular filtration rate (eGFR) of <45.0 mL/min/1.73 m2. Results: Regardless of obesity status and sex, a decreasing trend in eGFR was observed from the lowest to the highest TyG tertiles. Men without obesity and women with obesity in the middle and highest tertiles of the TyG index were 2.342 and 2.393 and 2.313 and 3.516 times more likely to have MSCKD, respectively. Those with obesity in the highest tertile of the TyG index were 1.736 and 2.374 times more likely to have MSCKD. Conclusion: Geriatric populations with an increased TyG index have a high risk of MSCKD regardless of obesity and sex. Our findings suggest that increased IR is associated with CKD in the geriatric population independent of obesity and sex.

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Use of the Visceral Adiposity Index as an Indicator of Chronic Kidney Disease in Older Adults: Comparison with Body Mass Index

Cited by 7 publications

References 46 publications

The association of visceral adiposity index with the risk of kidney stone and kidney stone recurrence

The association of visceral adiposity index with the risk of kidney stone and kidney stone recurrence

Triglyceride–Glucose Index as a Potential Indicator of Sarcopenic Obesity in Older People

The Triglyceride-Glucose Index is Independently Associated with Chronic Kidney Disease in the Geriatric Population, Regardless of Obesity and Sex

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