The association between a body shape index and elevated urinary albumin–creatinine ratio in Chinese community adults

Zhang, Yue; Gao, Wenxing; Li, Binqi; Liu, Yang; Chen, Kang; Wang, Anping; Tang, Xulei; Li, Yan; Luo, Zuojie; Qin, Guijun; Chen, Lulu; Wan, Qin; Gao, Zhengnan; Wang, Weiqing; Ning, Guang; Mu, Yiming

doi:10.3389/fendo.2022.955241

Cited by 4 publications

(5 citation statements)

References 38 publications

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“…And a previous study has found that ABSI was associated with depression and anxiety, but this correlation existed only in men ( 47 ). In addition to these diseases, Zhang et al have shown that higher ABSI was closely associated with higher urinary albumin-creatinine ratio ( 48 ). However, the studies mentioned above are aimed at exploring the association between ABSI and other diseases, and there is little evidence to compare ABSI with other anthropometric indicators in predicting the risk of AAC.…”

Section: Discussionmentioning

confidence: 99%

Association between a body shape index and abdominal aortic calcification in general population: A cross-sectional study

Wang²,

Li³

et al. 2023

Front. Cardiovasc. Med.

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BackgroundThe association between a body shape index (ABSI) and abdominal aortic calcification (AAC) is still unclear, so we tried to prove the association between ABSI and AAC in the general population in this cross-sectional study.Materials and methodsAfter excluding participants with missing data on height, weight, waist circumference (WC), and AAC, we finally selected 3,140 participants aged 40–80 years from the 2013–2014 National Health and Nutrition Examination Survey. Using multivariate logistic regression and receiver operating characteristic (ROC) curves to test the association between ABSI and AAC.ResultsParticipants (median age: 58.0 years; 48.3% men) were divided into two groups by the optimal cutoff point of ABSI: higher ABSI (> 0.84) and lower ABSI (≤ 0.84). Participants with higher ABSI showed significantly higher proportion of AAC than those with lower ABSI (39.8 vs. 23.7%, P < 0.001). Participants with higher ABSI had an increased risk of developing AAC in crude model (ABSI as a continuous variable: OR = 2.485, 95% CI: 2.099–2.942, P < 0.001; as a categorical variable: OR = 2.132, 95% CI: 1.826–2.489, P < 0.001), and ABSI was still independently associated with AAC in all adjusted models (all P < 0.05). Further subgroup analyses showed that higher ABSI was consistently associated with AAC in subgroups with sex (male or female), age (≤ 65 or > 65 years), smoking history (yes or no), hypertension (yes or no), diabetes (yes or no), sleep disorder (yes or no), body mass index (BMI) (< 23 or ≥ 23 kg/m2), systolic blood pressure (< 140 or ≥ 140 mmHg), diastolic blood pressure (< 90 or ≥ 90 mmHg), fasting plasma glucose (< 126 or ≥ 126 mg/dL), and low-density lipoprotein cholesterol (≤ 130 or > 130 mg/dL) (P for interaction > 0.05). While in other subgroups, the association was no longer synchronized. The ROC showed that the area under the curve of ABSI was significantly higher than height, weight, BMI, WC, and waist-to-height ratio (WHtR).ConclusionHigher ABSI was closely associated with higher risk of AAC, and discriminant ability of ABSI for AAC was significantly higher than height, weight, BMI, WC, and WHtR.

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Section: Discussionmentioning

confidence: 99%

Association between a body shape index and abdominal aortic calcification in general population: A cross-sectional study

Wang²,

Li³

et al. 2023

Front. Cardiovasc. Med.

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“…Concerns have been raised that interindividual differences in muscular mass have a significant influence on the uACR value via urinary creatinine excretion, that the uACR assessment overestimates urine albumin excretion in people who have low muscle mass, and therefore may not be associated with vascular disease 39 . BMI is the most commonly used metric for measuring obesity, but it lacks the ability to provide information on fat distribution and distinguish fat accumulation from muscle 40 . Therefore, further studies are warranted to elucidate the complex interaction between obesity and urinary albumin as well as the possible mediating role of obesity in the urinary albumin excretion−hypertension association.…”

Section: Discussionmentioning

confidence: 99%

“… 39 BMI is the most commonly used metric for measuring obesity, but it lacks the ability to provide information on fat distribution and distinguish fat accumulation from muscle. 40 Therefore, further studies are warranted to elucidate the complex interaction between obesity and urinary albumin as well as the possible mediating role of obesity in the urinary albumin excretion−hypertension association.…”

Section: Discussionmentioning

confidence: 99%

Association between urinary albumin‐to‐creatinine ratio within normal range and hypertension among adults in the United States: Data from the NHANES 2009–2018

Zhu

2023

Clinical Cardiology

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Background: Recently it was suggested that urine albumin-to-creatinine ratio (uACR), even within the normal range, can be associated with hypertension, but only a few studies have examined. Therefore, this study aimed to determine the association between normal range uACR and the prevalence of hypertension.Methods: The research used data from the 2009 to 2018 National Health and Nutrition Examination Survey, which included 14,919 participants. We defined the uACR as the amount of albumin (mg/dL) divided by creatinine (g/dL) in randomly voided urine. Hypertension was defined as mean systolic blood pressure ≥130 mmHg, or diastolic ≥80 mmHg, or were taking hypertension medication or were informed of a hypertension diagnosis by a physician/health professional.Results: In multivariable-adjusted models, per 5 mg/g uACR increment, the hypertension prevalence increased 1.31-fold (OR, 1.31; 95% CI 1.23-1.40), the odds [95% confidence interval (CI)] for hypertension prevalence were 2.25(1.86-2.72) for those in the highest quartile compared to those in the lowest quartile. The nonlinear relationship between hypertension prevalence and uACR was found by visually assessing images (p for nonlinearity<.001). In addition, in the subgroup analysis stratified by body mass index, the lower the BMI, the stronger the association between uACR and hypertension prevalence.Conclusions: Even within the normal range, subtly elevated uACR was associated with an increased prevalence of hypertension in the USA general population, and this association may be enhanced in individuals with low BMI. Further research is needed to assess the clinical applicability of these findings.

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“…Moreover, among Chinese community adults, Zhang et al . [ 31 ] identified a positive correlation between ABSI and urinary albumin-creatinine ratio. However, Wei Li et al .…”

Section: Discussionmentioning

confidence: 99%

Relationship between Novel Anthropometric Indices and the Prevalence of Abdominal Aortic Calcification: A Large Cross-Sectional Study

Yin,

Wu,

Lei

et al. 2023

Rev. Cardiovasc. Med.

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Background: The relationship between novel anthropometric indices, specifically a body shape index (ABSI) and body roundness index (BRI), with abdominal aortic calcification (AAC) or severe AAC (SAAC) is unclear. The aim of our study was therefore to investigate possible relationships between novel anthropometric indices and prevalence of AAC and SAAC. Methods: We obtained U.S. general population data from the National Health and Nutrition Examination Survey between 2013 and 2014. The study used restricted cubic spline (RCS) analysis, multivariable logistic regression modeling, subgroup analysis, and receiver operating characteristic (ROC) curve assessment. We investigated relationships between ABSI or BRI and AAC and SAAC risk. Associations between ABSI or BRI and the degree of AAC were also evaluated using a generalized additive model. Results: The study cohort was comprised of 1062 individuals. The RCS plots revealed a U-shaped curve associating ABSI with AAC risk. A similar trend emerged for SAAC, where the risk initially increased before subsequently decreasing with rising ABSI levels. Additionally, BRI exhibited a positive correlation with both AAC and SAAC risk. As ABSI and BRI values increased, the degree of AAC also increased. In ROC analysis, ABSI displayed a significantly larger area under the curve compared to BRI. Conclusions: ABSI is associated with AAC prevalence following a U-shaped curve. Additionally, BRI is positively correlated with AAC risk. ABSI demonstrates a superior discriminative ability for AAC compared to BRI. Therefore, maintaining an appropriate ABSI and BRI may reduce the prevalence of AAC.

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The association between a body shape index and elevated urinary albumin–creatinine ratio in Chinese community adults

Cited by 4 publications

References 38 publications

Association between a body shape index and abdominal aortic calcification in general population: A cross-sectional study

Association between a body shape index and abdominal aortic calcification in general population: A cross-sectional study

Association between urinary albumin‐to‐creatinine ratio within normal range and hypertension among adults in the United States: Data from the NHANES 2009–2018

Relationship between Novel Anthropometric Indices and the Prevalence of Abdominal Aortic Calcification: A Large Cross-Sectional Study

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