The −590C/T polymorphism in the IL-4 gene and the risk of cancer: a meta-analysis

Abstract

Interleukin-4 (IL-4) plays an important role in the pathogenesis of cancer. The -590C/T polymorphism in the IL-4 gene has been implicated in susceptibility to cancer, but the results have been inconclusive. The aim of this study was to analyze the association between this polymorphism with the risk of cancer by meta-analysis. PubMed, Embase, CNKI, and Wanfang databases were searched for all publications concerning the association between this polymorphism and cancer risk. Statistical analyses were analyzed by using RevMan 4.2 and STATA10.0 softwares. A total of 8,715 cases and 9,532 controls in 23 case-control studies were included. The results suggested that there was no significant association between IL-4 -590C/T polymorphism and cancer risks (TT + TC vs. CC: OR = 0.97, 95 % CI = 0.90-1.04, P = 0.36). In the subgroup analysis by ethnicity, no significant association was detected in Asians and Caucasians. In the subgroup analysis by cancer types, no significant association was found in gastric cancer and colorectal cancer. The current meta-analysis suggested that the -590C/T polymorphism in the IL-4 gene might not be associated with increased/decreased risk of cancer. The -590C/T polymorphism might be not a risk factor for cancers.

Interleukin-4 and -8 Gene Polymorphisms and Risk of Gastric Cancer in a Population in Southwestern China

“…Despite distinct allele and genotype frequencies, the negative association with GC is, however, consistent among different populations. Our finding is also validated in a meta-analysis that pooled all existing studies for association analysis for cancer risk and subgroup analysis for GC (Zhang et al, 2013). What is noteworthy is that a higher risk of developing diffuse type (OR, 1.64; 95%, CI 1.01-2.67) or cardia cancer (OR, 2.44, 95%CI 1.13-2.67) was observed for the CT/CC genotype in Chinese Taiwan, which is contradictory to our result for subgroup analysis (Wu et al, 2003).…”

“…Of three common polymorphisms in the IL8 gene, the T-to-A base substitution at -251 (T-251A, rs4073) of the promoter region is associated with increased IL-8 production (Hull et al, 2000). To date, although multiple studies have been conducted on association of IL4-590 C>T (Loh et al, 2009;Sugimoto et al, 2010;Zhang et al, 2013) and IL8-251 T>A (Gianfagna et al, 2008;Gao et al, 2010;Liu et al, 2010;Wang et al, 2010;Persson et al, 2011;Yuzhalin, 2011;Wang et al, 2012;Xue et al, 2012) and GC among Asians, Caucasians and Hispanics, results are hardly conclusive with evident variability according to race. Even within the Chinese population, studies report conflicting results among studies in Taiwan (Wu et al, 2003;Lai et al, 2005;Lee et al, 2005), Fujian (Lin, 2008), Hebei (Zhang et al, 2010), Beijing (Lu et al, 2005), Guangdong and Shanxi (Zeng et al, 2005) for each polymorphism.…”

Genetic association between interluekin-4 rs2243250 polymorphism and gastric cancer susceptibility: evidence based on a meta-analysis

“…In the past 2 years, two meta-analyses investigated the association. 9 , 10 Interestingly, the conclusions of the two previous meta-analyses were contradictory. In addition, more case–control studies have been published during these past 2 years.…”

Genetic analysis of pharmacogenomic VIP variants in the Blang population from Yunnan Province of China

“…Numerous studies showed that the frequency of rs3814055 in the NR1I2 gene varied according to different populations. The frequency of this variation in a Chinese Han population was 0.218 (Wang et al, ), 0.39 for Caucasians (Zhang et al, ), 0.21 for Asians (King et al, ), 0.50 for Europeans (King et al, ), 0.36 for the Dutch (Bosch et al, ), and 0.34 for African Americans (Thomas et al, ). In our previous studies, the frequency of the rs3814055 SNP variant in the Lhoba population and in the Miao population were 0.101 and 0.09 (He et al, ; Jin, Aikemu et al, ), respectively.…”