Interleukin-4 and -8 Gene Polymorphisms and Risk of Gastric Cancer in a Population in Southwestern China

Wen, Ying; Loh, Marie; Wen, Yan; Zhao, Zhenze; Huang, He; Lan, Hui Y.; Chen, Feng; Soong, Richie; Yang, Chunxia

doi:10.7314/apjcp.2014.15.7.2951

Cited by 21 publications

(21 citation statements)

References 54 publications

(78 reference statements)

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“…To understand the potential functional roles of differentially expressed mRNAs, GO category and KEGG pathway annotation were further used to analyze the gene pool. GO categories showed several terms enriched for dysregulated transcripts including negative regulation of IL-4 production, which was studied previously in GC 25 (Fig. 2).…”

Section: Discussionsupporting

confidence: 59%

Long noncoding ribonucleic acid specific for distant metastasis of gastric cancer is associated with TRIM16 expression and facilitates tumor cell invasion in vitro

Yan

Shen

Gao

et al. 2015

J of Gastro and Hepatol

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Section: Discussionsupporting

confidence: 59%

Long noncoding ribonucleic acid specific for distant metastasis of gastric cancer is associated with TRIM16 expression and facilitates tumor cell invasion in vitro

Yan

Shen

Gao

et al. 2015

J of Gastro and Hepatol

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“…Table 2 presents the characteristics of the studies included in the meta-analysis. The studies were conducted using either population or hospital controls in various countries and investigated gastrointestinal cancers, including esophageal,13, 14 gastric,13, 15, 16, 17, 18, 19, 20, 21, 22, 23 colorectal,24, 25, 26, 27, 28, 29, 30, 31, 32 hepatocellular,33, 34 and pancreatic cancer 35, 36, 37…”

Section: Resultsmentioning

confidence: 99%

Association of IL4 , IL13 , and IL4R polymorphisms with gastrointestinal cancer risk: A meta-analysis

Cho

Kim

2017

Journal of Epidemiology

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BackgroundPrevious studies have suggested that IL4, IL13, and IL4R are associated with serum IgE levels and allergies, and common variants of these genes may alter cancer risk. To clarify these associations, we conducted a meta-analysis to investigate the associations of IL4, IL13, and IL4R polymorphisms with gastrointestinal cancer risk.MethodsWe used 27 eligible case–control studies describing the associations of six polymorphisms of IL4, IL13, and IL4R with gastrointestinal cancer risk to calculate summary odds ratios (ORs) and 95% confidence intervals (CIs) using five different genetic models. The Q-statistic and I2 statistic were calculated to examine heterogeneity.ResultsThe IL4 rs2070874 T allele seems to be associated with an increased risk of gastrointestinal cancer (OR 1.11; 95% CI, 1.00–1.24 for T allele vs. C allele). This association was significant in studies conducted outside of Asia (OR 1.28; 95% CI, 1.03–1.58 for T allele vs. C allele) and in studies investigating the association with gastric cancer (OR 1.17; 95% CI, 1.03–1.34 for T allele vs. C allele). However, the IL4R rs1801275 heterozygote seems to be associated with a reduced risk of gastrointestinal cancer (OR 0.79; 95% CI, 0.65–0.96 for AG vs. AA). Other polymorphisms did not show any significant associations with gastrointestinal cancer risk in any of the genetic models and subgroup analyses.ConclusionsOur results suggest that certain polymorphisms of IL4 and IL4R may affect susceptibility to gastrointestinal cancer. However, further studies are required to confirm these findings.

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“…These results suggest that positive discovery of IL-10 expression may be used as a molecular marker for characterizing of gastric. Xiong-Fei in his paper said that since IL-10 can both reduce and enhance anti-cancer possessions, it may be significant to discover the role of IL10 polymorphisms in the development of Gastric Cancer in different clinical stages, or Gastric Cancer of different subsites (44) . Results of another study demonstrated that the intraperitoneal with IL-10 treatment was able suppressed peritoneal dissemination of gastric cancer cells and reduce peritoneal metastasis and increase survival rate, in the inoculated mice (3) .…”

Section: Discussionmentioning

confidence: 99%

Serum Cytokine of Il-2, Il-10 and Il-12 Levels in Patients With Stomach Adenocarcinoma

Shokrzadeh

Mohammadpour

Hoseini

et al. 2018

Arq. Gastroenterol.

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BACKGROUND: Gastric adenocarcinoma is the fourth most common cause of cancer-associated death worldwide. OBJECTIVE: We evaluated the immunological status of patients with gastric cancer before surgery and circulating cytokines as potential diagnostic biomarkers for gastric cancer. METHODS: We included 90 healthy controls and 95 patients with distal Gastric adenocarcinoma in Mazandaran, Sari, Iran. We measured serum IL-2, IL-10 and IL-12 Levels by a sandwich enzyme-linked immunosorbent assay using the IBL international GMBH kit. RESULTS: The serum IL-10 levels in the patients with Gastric adenocarcinoma were significantly higher than those of the healthy controls (P=0.02). There were no significant differences in serum IL-2 and IL-12 levels between patients with gastric cancer and healthy controls. CONCLUSION: Increased levels of IL-10 might be useful as diagnostic biomarkers for Gastric adenocarcinoma; however, this needs to be confirmed with larger number of patients and with control groups other than blood donors, properly age paired. These results suggest that positive expression of IL-10 may be useful as a molecular marker to distinguish stage of gastric cancers which can be more readily controlled.

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Interleukin-4 and -8 Gene Polymorphisms and Risk of Gastric Cancer in a Population in Southwestern China

Cited by 21 publications

References 54 publications

Long noncoding ribonucleic acid specific for distant metastasis of gastric cancer is associated with TRIM16 expression and facilitates tumor cell invasion in vitro

Long noncoding ribonucleic acid specific for distant metastasis of gastric cancer is associated with TRIM16 expression and facilitates tumor cell invasion in vitro

Association of IL4 , IL13 , and IL4R polymorphisms with gastrointestinal cancer risk: A meta-analysis

Serum Cytokine of Il-2, Il-10 and Il-12 Levels in Patients With Stomach Adenocarcinoma

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