The 13 Urea Breath Test for the Noninvasive Detection ofHelicobacter pylori in Children: Comparison with Culture and Determination of Minimum Analysis Requirements

Kalach, Nicolas; Briet, F.; Raymond, Josette; Benhamou, Pierre-Henri; P, Barbet; Bergeret, M.; Senouci, L.; Maurel, M.; Flourié, Bernard; Dupont, Christophe

doi:10.1097/00005176-199803000-00010

Cited by 70 publications

(51 citation statements)

References 10 publications

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“…Rowland et al reported sensitivity and specificity of 100% and 97.6% respectively (27) . Kalach et al found 100% and 98.3% for specificity and sensitivity, respectively (15) . Findings of Vandenplas et al showed 96% and 93% for sensitivity and specificity (29) .…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of Urea Breath Test for Helicobacter Pylori Infection in Children With Dyspepsia in Comparison to Histopathology

Honar

Minazadeh

Shakibazad

et al. 2016

Arq. Gastroenterol.

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-Background -Helicobacter pylori infection is the gram negative bacillus with the close association with chronic antral gastritis. Objective -In this study, we evaluate the accuracy of urea breath test (UBT) with carbon isotope 13 in comparison with histopathology of gastric antrum for detection of H. pylori infection in children with dyspepsia. Methods -This cross-sectional study was performed at specialized laboratory of Shiraz Gastroenterohepatology Research Center and Nemazee Hospital, Iran, during a 12-months period. This study investigated the sensitivity, specificity, and positive and negative predictive values of UBT in comparison with biopsy-based tests. We included a consecutive selection of 60 children who fulfilled Rome III criteria for dyspepsia. All children were referred for performing UBT with carbon isotope 13 (C13) as well as endoscopy. Biopsies were taken from antrum of stomach and duodenum. The pathologic diagnosis was considered as the standard test. Results -The mean age of the participants was 10.1±2.6 (range 7-17 years). From our total 60 patients, 28 (46.7%) had positive UBT results and 32 (53.3%) had negative UBT results. Pathologic report of 16 (57.1%) out of 28 patients who had positive UBT were positive for H. pylori and 12 (42.9%) ones were negative. Sensitivity and specificity of C13-UBT for detection of H. pylori infection were 76.2% and 69.2% respectively. Conclusion -Sensitivity and specificity of C13-UBT for detection of H. pylori infection were 76.2% and 69.2% respectively. Another multicenter study from our country is recommended. HEADINGS -Child health. Dyspepsia. Gastritis. Helicobacter infections. Peptic ulcer. Urease.

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Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of Urea Breath Test for Helicobacter Pylori Infection in Children With Dyspepsia in Comparison to Histopathology

Honar

Minazadeh

Shakibazad

et al. 2016

Arq. Gastroenterol.

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“…UBT has been validated (28,53,242,250,253,362,481,542) and is the most highly recommended noninvasive test for children. The protocol used in adults can be followed.…”

Section: Application In Different Clinical Settingsmentioning

confidence: 99%

Helicobacter pyloriDetection and Antimicrobial Susceptibility Testing

2007

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SUMMARY The discovery of Helicobacter pylori in 1982 was the starting point of a revolution concerning the concepts and management of gastroduodenal diseases. It is now well accepted that the most common stomach disease, peptic ulcer disease, is an infectious disease, and all consensus conferences agree that the causative agent, H. pylori, must be treated with antibiotics. Furthermore, the concept emerged that this bacterium could be the trigger of various malignant diseases of the stomach, and it is now a model for chronic bacterial infections causing cancer. Most of the many different techniques involved in diagnosis of H. pylori infection are performed in clinical microbiology laboratories. The aim of this article is to review the current status of these methods and their application, highlighting the important progress which has been made in the past decade. Both invasive and noninvasive techniques will be reviewed.

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“…Studies with adults 96 and with children older than 6 years 97,98 have shown that the breath test has sensitivity and specificity higher than 95.0%.…”

Section: Carbon 13-labeled Urea Breath Testmentioning

confidence: 98%

Úlcera péptica gastroduodenal e infecção pelo Helicobacter pylori na criança e adolescente

Bittencourt¹,

Rocha²,

Penna³

et al. 2006

J. Pediatr. (Rio J.)

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Objective: To show important aspects of gastroduodenal peptic ulcer and of Helicobacter pylori infection in children and adolescents. Sources: Technical textbooks and MEDLINE and LILACS databases including publications between 1966 and 2006.Summary of the findings: The etiology of peptic ulcer in children and adolescents may be primary, associated with H. pylori infection, or secondary, in which etiopathogenic mechanisms rely upon the underlying disease. The infection is acquired predominantly in childhood, with prevalence rates between 56.8 and 83.1% in children who live in the poorest Brazilian regions, amounting to nearly 10% in children aged less than 10 years in industrialized countries. The infection can be diagnosed by invasive methods, which investigate the presence of the bacterium, or of DNA, RNA or bacterial products in biopsy fragments of the gastric mucosa obtained at endoscopic examination; it can also be diagnosed through noninvasive methods, which include the detection of anti-H. pylori antibodies in serum, urine or saliva samples, detection of bacterial antigens in stool samples, and the carbon 13-labeled urea breath test. However, upper gastrointestinal endoscopy is the method of choice for the diagnosis of peptic ulcer, as it allows collecting fragments from the gastric mucosa during the procedure for the diagnosis of infection and for histopathological analysis.Conclusions: H. pylori infection is the major cause of peptic ulcer among children. Eradication of the bacterium with antimicrobial therapy results in the cure of the disease, and is therefore indicated for all children with H. pylori infection with an active, recurrent, healed, or complicated peptic ulcer.

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The 13 Urea Breath Test for the Noninvasive Detection ofHelicobacter pylori in Children: Comparison with Culture and Determination of Minimum Analysis Requirements

Abstract: 13carbon urea breath test is sensitive and specific in children. Two samples collected at T0 and T40 provide the most discriminating procedure.

Cited by 70 publications

References 10 publications

Diagnostic Accuracy of Urea Breath Test for Helicobacter Pylori Infection in Children With Dyspepsia in Comparison to Histopathology

Diagnostic Accuracy of Urea Breath Test for Helicobacter Pylori Infection in Children With Dyspepsia in Comparison to Histopathology

Helicobacter pyloriDetection and Antimicrobial Susceptibility Testing

Úlcera péptica gastroduodenal e infecção pelo Helicobacter pylori na criança e adolescente

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