The 10trans,12cis isomer of conjugated linoleic acid suppresses the development of hypertension in Otsuka Long–Evans Tokushima fatty rats

Nagao, Koji; Inoue, Nao; Wang, Yu Ming; Hirata, Junichi; Shimada, Yuji; Nagao, Toshihiro; Matsui, Toshiro; Yanagita, Teruyoshi

doi:10.1016/s0006-291x(03)00929-x

Cited by 83 publications

(58 citation statements)

References 32 publications

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“…It has been reported that conjugated linoleic acid (CLA), the CFA form of linoleic acid, has favorable physiological effects, such as anti-atherosclerosis, anti-obesity, anti-tumor, and anti-hypertension. [1][2][3][4][5][6][7][8][9] There are also other types of CFA in some plant seed oils. Punicic acid (9cis,11trans,13cis-conjugated linolenic acid; 9c,11t,13c-CLNA) is contained at about 72% in pomegranate seed oil.…”

mentioning

confidence: 99%

The 9cis,11trans,13cisIsomer of Conjugated Linolenic Acid Reduces Apolipoprotein B100 Secretion and Triacylglycerol Synthesis in HepG2 Cells

Arao

Yotsumoto

Han

et al. 2004

Bioscience, Biotechnology, and Biochemistry

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mentioning

confidence: 99%

The 9cis,11trans,13cisIsomer of Conjugated Linolenic Acid Reduces Apolipoprotein B100 Secretion and Triacylglycerol Synthesis in HepG2 Cells

Arao

Yotsumoto

Han

et al. 2004

Bioscience, Biotechnology, and Biochemistry

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“…[3][4][5] Therefore, an effect of CLA on BP could be expected in humans as well. A possible mechanism by which CLA and other trans fatty acids might influence blood pressure could be through endothelial function.…”

Section: Discussionmentioning

confidence: 99%

“…2 In addition, CLA was found to lower blood pressure (BP) in several rat models. [3][4][5] On the other hand, CLA is a trans fatty acid and its harmful effects on the cardiovascular system cannot be excluded. Little is known about the effect of CLA on human BP.…”

Section: Introductionmentioning

confidence: 99%

The effect of conjugated linoleic acid, a natural trans fat from milk and meat, on human blood pressure: results from a randomized crossover feeding study

et al. 2011

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Cis-9, trans-11 conjugated linoleic acid (CLA) is a natural trans fatty acid that is largely restricted to ruminant fats and consumed in foods and supplements. Its role in blood pressure (BP) regulation is still unclear. We examined the effect of cis-9, trans-11 CLA on BP compared with oleic acid. A total of 61 healthy volunteers were sequentially fed each of 3 diets for 3 weeks, in random order, for a total of 9 weeks. The diets were identical except for 7% of energy (18.9 g in a diet of 10 MJ day -1 ) that was provided either by oleic acid, by industrial trans fatty acids or by cis-9, trans-11 CLA. We measured BP on two separate days at the end of each intervention period. At baseline, mean BP was 113.8 ± 14.4 mm Hg systolic and 66.3 ± 9.6 mm Hg diastolic. The effect of the CLA diet compared with the oleic acid diet was 0.11 mm Hg (95% confidence interval: À1.27, 1.49) systolic and À0.45 mm Hg (À1.63, 0.73) diastolic. After the industrial trans fatty acid diet, the effect was 1.13 mm Hg (À0.25, 2.51) systolic and À0.44 mm Hg (À1.62, 0.73) diastolic compared with the oleic acid diet. Our study suggests that short-term high intakes of cis-9,trans-11 CLA do not affect BP in healthy volunteers.

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“…After 10 min, n-hexane was dried under nitrogen stream, water was added (3 lL), and the samples were incubated at 30°C for different reaction times (8,16,24, 32 and 48 h), using a magnetic stirrer (Mod. F-80, Falc Instrument, Treviglio, Italy).…”

Section: Chemical Synthesis Of L-menthyl-cla Standardmentioning

confidence: 99%

“…In fact, the c9,t11-CLA isomer is associated with anticancer activity [12], while the t10,c12-CLA isomer plays a role in decreasing body fat, increasing energy expenditure [13][14][15] and reducing hypertension [16]. For this reason, it is important to develop an efficient process for producing purified CLA isomers.…”

Section: Introductionmentioning

confidence: 99%

Candida rugosa lipase selectivity toward trans,cis- and cis,trans-conjugated linoleic acid isomers

Giua

Cossignani

Simonetti

et al. 2012

Eur Food Res Technol

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It is known that conjugated linoleic acid (CLA) isomers have different beneficial health effects, and it has been demonstrated that the effects of CLA may be isomer dependent. For this reason, CLA isomer fractionation is a very important topic, and recently, various enzymatic methods for the fractionation of CLA isomers have been studied. In this paper, a commercial CLA standard including four isomers (c11,t13-, t10,c12-, c9,t11-and t8,c10-CLA) were subjected to enzymatic esterification with L-menthol in order to examine the ability of Candida rugosa lipase to discriminate among the isomers. The lipase was incubated at 30°C for different reaction times, and subsequently, the degree of enzymatic esterification was established by high-performance liquid chromatography (HPLC) with light scattering detection. Moreover, in this study, a silver-ion HPLC analysis was developed to determine the isomer profile of L-menthyl-CLA. Since the t8,c10-and c11,t13-CLA isomers are not commercially available, they were obtained by sigmatropic rearrangement of c9,t11-and t10,c12-CLA, respectively. The highest selectivity for the c9,t11-CLA isomer was obtained when enzymatic esterification was carried out for 8 h. This study demonstrated that C. rugosa lipase has a higher selectivity for cis,trans isomers, than for trans,cis isomers; in particular, it has a higher selectivity for c9,t11-than for c11,t13-CLA.

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The 10trans,12cis isomer of conjugated linoleic acid suppresses the development of hypertension in Otsuka Long–Evans Tokushima fatty rats

Cited by 83 publications

References 32 publications

The 9cis,11trans,13cisIsomer of Conjugated Linolenic Acid Reduces Apolipoprotein B100 Secretion and Triacylglycerol Synthesis in HepG2 Cells

The 9cis,11trans,13cisIsomer of Conjugated Linolenic Acid Reduces Apolipoprotein B100 Secretion and Triacylglycerol Synthesis in HepG2 Cells

The effect of conjugated linoleic acid, a natural trans fat from milk and meat, on human blood pressure: results from a randomized crossover feeding study

Candida rugosa lipase selectivity toward trans,cis- and cis,trans-conjugated linoleic acid isomers

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