The 1-Minute Sit-to-Stand Test in Lung Transplant Candidates: An Alternative to the 6-Minute Walk Test

Abstract

BACKGROUND: The 6-min walk test (6MWT) is a well-established functional exercise capacity test in lung transplant candidates. This study aimed to investigate the construct validity of the 1-min sit-to-stand test (1-min STS) as a marker of exercise capacity and knee extensor strength in lung transplantation candidates. METHODS: We retrospectively analyzed data from consecutive subjects referred for lung transplantation evaluation to our institution between 2015 and 2018. RESULTS: 38 subjects were included. We found strong correlations between the normalized 1-min STS and 6MWT (r ‫؍‬ 0.79, P < .001) and moderate correlations between 1-min STS and knee extensor strength (r ‫؍‬ 0.53, P ‫؍‬ .001) and between 6MWT and knee extensor strength (r ‫؍‬ 0.44, P ‫؍‬ .008). The 1-min STS elicited greater dyspnea (P ‫؍‬ .008) and lower oxygen desaturation compared to the 6MWT (P < .001). CONCLUSIONS: The 1-min STS is a valid functional exercise capacity test in lung transplantation candidates. Due to its ease of application, clinical practitioners may consider using the 1-min STS in situations when the 6MWT cannot be performed. Our pilot study may stimulate future research, including a head-to-head comparison between the 6MWT and 1-min STS in a large patient cohort including post-lung transplantation-monitoring.

What is the Efficacy and Safety of Rapid Exercise Tests for Exertional Desaturation in Covid-19: A Rapid Systematic Review&nbsp;

“…We placed less weight on the nal ve studies -either because the sample was people with ventilation rather than perfusion defects and the methodological quality was uncertain, or because methodological quality was considered to be poor on our risk of bias and applicability tool, though the ndings from all these additional studies were similar to the above ones. These studies were: Gruet et al (a prospective correlation study from France in 25 patients with cystic brosis, which concluded that the 1MSTST may be used as an alternative to the 6MWT and CPET for assessing exertional desaturation) [45]; Morita et al (a study in 23 patients with COPD which showed good correlation between various exercise desaturation tests) [46]; Kohlbrenner et al (a retrospective study from Switzerland in 38 lung transplant candidates which concluded that the 1MSTST is a safe alternative to 6MWT in such patients despite lower desaturation nadirs) [47]; Crook et al (a prospective study in 21 COPD patients which concluded that 1MSTST is a safe and accurate alternative to 6MWT); and Azzi et al (a retrospective study in 36 lung cancer patients whose main aim was to compare a 3-minute chair-to-rise test, 3MCTRT, with the CPET in terms of maximal exercise capacity but which also found high correlation with the level of oxygen desaturation achieved) [48].…”

Testes funcionais validados em indivíduos hospitalizados e não hospitalizados: revisão sistemática

“…Dos 13 artigos, 10 eram estudos observacionais longitudinais [70][71][72][73][74][75]77,78,80,82 , dois observacionais de corte transversal 76,79 e um utilizou dados de ensaios clínicos 81 . Apenas dois foram realizados em indivíduos hospitalizados, sendo um no departamento de emergência 70 e outro em adultos mais velhos 77 .…”

“…Apenas dois foram realizados em indivíduos hospitalizados, sendo um no departamento de emergência 70 e outro em adultos mais velhos 77 . Quanto à execução do teste, foram utilizadas cadeiras de 48 cm 74,81 , 46 -48 cm 71 , 46 cm 75 , 45,7 cm 77 , 45 cm 78 , 43,2 cm 73 , 43 cm 79 , cadeira ajustável para manter os quadris a 90 graus 76,82 e sem apoio para os braços [70][71][72][73][74][75]79 . Em apenas três artigos os indivíduos puderam usar os braços 76,77,80 .…”

“…Em apenas três artigos os indivíduos puderam usar os braços 76,77,80 . A duração dos testes variou entre um minuto 71,75 , 30 s 70,74,77 ; repetição em 5 vezes 72,74,75,78,77,82 e 10 vezes 80 . No artigo de Staartjes et al 81 foi realizada uma familiarização com o teste, sendo executado sem cronometrar.…”

“…O TSO é um teste válido [71][72][73][74][75][76][77]80,82 e confiável [71][72][73][74]7679,81,82 . Apresentou correlações com VO 2 máx, produção de dióxido de carbono 71 e capacidade funcional e de equilíbrio 76 , força dos flexores e extensores de joelho 75,79 . O teste também demonstrou associação com outros instrumentos como TC6 71,75 , Berg Balance Scale (BBS), Índice de Barthel modificado 77 , Roland-Morris Disability Questionnaire (RMDQ), Oswestry Disability Index (ODI), escala analógica visual (EVA) e Escala Europeia de Qualidade de Vida (EQ-5D) 81 .…”