Thalidomide in the treatment of recalcitrant Sweet's syndrome associated with myelodysplasia

Sweet's syndrome – a comprehensive review of an acute febrile neutrophilic dermatosis

“…These observations have predominantly been described in case reports. The agents include cytotoxic chemotherapies and antimetabolites (chlorambucil and cyclophosphamide) [30,39,148,200,251,360,390], immunoglobulin [303], interferon alpha [202,366], etretinate [361], and tumor necrosis factors antagonists (etanercept [392], infliximab [264,278,266], and thalidomide [5,393,425]). Pentoxifylline was postulated to be of therapeutic benefit for treating Sweet's syndrome [394,395]; however, it was not found to be efficacious when used as monotherapy [1,2,7,295,362].…”

Chronic Recurrent Lymphocytic Sweet Syndrome as a Predictive Marker of Myelodysplasia

“…13,18,19 Myelodysplastic syndrome occurred at the onset of cutaneous disease in 2 patients or followed it 3 years later in 1. In a series of 37 patients with Sweet syndrome who had undergone sequential biopsies, the initial lymphocytic stage was followed by neutrophilic and then histiocytic infiltrates.…”

Síndrome de Sweet asociado a neoplasias

“…3-In case # 3, the progression of a myelodysplastic syndrome to an acute myeloid leukemia was noted, 28,29 coinciding with the appearance of the…”

“…3,5,23 Recently a case report was published of recalcitrant Sweet syndrome associated with myelodysplastic syndrome that responded successfully to treatment with thalidomide. 28 Recurrence was observed in 30% of patients with the idiopathic form, growing to 70% in the paraneoplastic form. Relapses were associated with a guarded prognosis, since in many cases it coincided with the progression of the underlying disease or recurrence of an earlier neoplasm.…”