Sweet's syndrome – a comprehensive review of an acute febrile neutrophilic dermatosis

Cohen, Philip R.

doi:10.1186/1750-1172-2-34

Cited by 729 publications

(1,154 citation statements)

References 382 publications

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“…3.4 Its distribution is universal and there is no racial predilection. 2,3,4 Women are more commonly affected and, in particular, seem to be more affected by the idiopathic or drug-induced forms. 4 The onset of the disease can occur at any age, but the peak incidence is usually from the fourties to the seventies.…”

Section: Introductionmentioning

confidence: 99%

Síndrome de Sweet: estudo de 23 casos

Wojcik

Nishimori

Santamaria

2011

An. Bras. Dermatol.

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BACKGROUND: Sweet's syndrome or acute febrile neutrophilic dermatosis is a rare disease characterized by painful violaceous erythematous skin lesions, fever, neutrophilic leukocytosis and dense dermal neutrophilic inflammatory infiltrate. It shows excellent response to corticosteroids. OBJECTIVES: To assess cases of Sweet's syndrome in a university hospital, identifying its clinical, laboratory and epidemiological characteristics and compare them with the data found on the literature. METHODS: We conducted a retrospective epidemiological study by examining the medical records of 23 patients who met the diagnostic criteria for the disease from March 1995 to July 2009. We collected clinical and epidemiological data on the patients, such as lesion location, presence of cutaneous and extracutaneous manifestations, conditions associated with SS and some laboratory data, such as leukocyte count and ESR. RESULTS: The age of the patients in the study ranged from 2 to 75 years. There were more females. The lesions mostly affected the trunk and upper limbs. Fever was the most common systemic manifestation, followed by arthralgia and myalgia, conjunctivitis and arthritis. The triggering factors most commonly identified were infections of the respiratory tract. Associated neoplasia occurred in 30% of the patients, especially hematologic neoplasia. CONCLUSION: The clinical and epidemiological data found in our study are mostly similar to those found in the literature. Given the high prevalence of malignant diseases in patients with Sweet's syndrome, it is necessary to know how to perform the diagnosis, carry out a full investigation as well as do the patient's follow up. Keywords: Epidemiology; Neutrophils; Sweet syndrome Resumo: FUNDAMENTOS: A síndrome de Sweet (SS) é uma doença rara, caracterizada por lesões cutâneas eritematovioláceas dolorosas, febre, leucocitose com neutrofilia e derme com infiltrado inflamatório neutrofílico denso à histologia. Apresenta excelente resposta à corticoterapia. OBJETIVOS: Avaliar os casos de SS em hospital universitário, identificando as características clínicas, laboratoriais e epidemiológicas e compará-las com os dados da literatura. MÉTODOS: Realizou-se estudo epidemiológico, retrospectivo, mediante revisão de prontuários. Identificaram-se 23 pacientes que preencheram os critérios diagnósticos para a doença no período de março de 1995 a julho de 2009. Coletaram-se dados clínicos e epidemiológicos dos pacientes, tais como: localização das lesões, presença de manifestações cutâneas e extracutâneas, condições associadas à SS e alguns dados laboratoriais, como contagem de leucócitos e velocidade de hemossedimentação (VHS). RESULTADOS: As idades variaram entre 2 e 75 anos. Houve predomínio do sexo feminino. As lesões acometeram, preferencialmente, tronco e membros superiores. Febre foi a manifestação sistêmica mais comum, seguida por artralgias e mialgia, conjuntivite e artrite. Os fatores desencadeantes mais comumente detectados foram infecções de vias aéreas. Neoplasias associada...

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Section: Introductionmentioning

confidence: 99%

Síndrome de Sweet: estudo de 23 casos

Wojcik

Nishimori

Santamaria

2011

An. Bras. Dermatol.

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“…The minor diagnostic criteria for classical Sweet's syndrome are leukocytosis ([8,000/mm 3 ) and neutrophilia ([70 %) [1,2]. However, Sweet's syndrome reported in a few cases of AML during leukopenic and/or neutropenic period following chemotherapy [9].…”

Section: Discussıonmentioning

confidence: 99%

“…This syndrome often occurs in association with malignancies, inflammatory diseases or drugs but an idiopathic (classical) form also exists, usually in adult women [1,2]. Granulocyte colonystimulating factor (G-CSF) induced Sweet's syndrome has been reported to date in only two children, one with glycogen storage disease type Ib and the other with aplastic anemia [3,4].…”

Section: Introductionmentioning

confidence: 99%

Granulocyte Colony Stimulating Factor Induced Sweet’s Syndrome Following Autologous Transplantation in a Child with Relapsed Acute Myeloblastic Leukemia

Kaya

Belen

Akyürek

2014

Indian J Hematol Blood Transfus

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“…These data suggest that a functional cross-talk between these two populations might occur in SS. Since neutrophil-survival cytokines, including IFNγ, have been associated with the etiology of the disease, 21 the presence of NK cells in Sweet's syndrome inflammatory infiltrate, likely producing IFNγ, provides new insights into the pathogenesis of this dermatosis and paves the way for novel therapeutic strategies. IFNγ (pg/mL)…”

Section: Neutrophils Co-localize With Nk Cells In Sweet's Syndromementioning

confidence: 99%

On the potential involvement of CD11d in co-stimulating the production of interferon- by natural killer cells upon interaction with neutrophils via intercellular adhesion molecule-3

et al. 2011

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Sweet's syndrome – a comprehensive review of an acute febrile neutrophilic dermatosis

Cited by 729 publications

References 382 publications

Síndrome de Sweet: estudo de 23 casos

Síndrome de Sweet: estudo de 23 casos

Granulocyte Colony Stimulating Factor Induced Sweet’s Syndrome Following Autologous Transplantation in a Child with Relapsed Acute Myeloblastic Leukemia

On the potential involvement of CD11d in co-stimulating the production of interferon- by natural killer cells upon interaction with neutrophils via intercellular adhesion molecule-3

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