Th-P15:224 Simultaneous transfer to HDL of cholesterol, triglycerides and phospholipids in aging and coronary artery disease

Azevedo, Carolina Heitmann Mares; Puk, Camila Góes; Feitosa-Filho, Gilson Soares; Prete, Ana Cristina Lo; Seydell, T.; Diament, J; Wajngarten, Maurı́cio; Maranhao, R.C.

doi:10.1016/s1567-5688(06)82183-5

Cited by 6 publications

(7 citation statements)

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“…Conceivably, compositional changes in the HDL fraction may also change the ability of this lipoprotein to take up lipids from other lipoprotein classes or, as is the case here, from a standard donor nanoemulsion. Recently, our group showed that in subjects that had precocious coronary artery disease the in vitro transfer of NEC to HDL was reduced [36,37]. Since HDL is the main cholesterol esterification site in the circulation and this reaction is essential for stabilization of the plasma cholesterol pool and for reverse cholesterol transport, reduction in NEC transfer to HDL may affect important functions of this lipoprotein, increasing cardiovascular risk.…”

Section: Discussionmentioning

confidence: 99%

Lipid Transfer to HDL is Higher in Marathon Runners than in Sedentary Subjects, but is Acutely Inhibited During the Run

Vaisberg

Bachi

Latrilha

et al. 2012

Lipids

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Although exercise increases HDL-cholesterol, exercise-induced changes in HDL metabolism have been little explored. Lipid transfer to HDL is essential for HDL's role in reverse cholesterol transport. We investigated the effects of acute exhaustive exercise on lipid transfer to HDL. We compared plasma lipid, apolipoprotein and cytokine levels and in vitro transfer of four lipids from a radioactively labeled lipid donor nanoemulsion to HDL in sedentary individuals (n = 28) and in marathon runners (n = 14) at baseline, immediately after and 72 h after a marathon. While HDL-cholesterol concentrations and apo A1 levels were higher in marathon runners, LDL-cholesterol, apo B and triacylglycerol levels were similar in both groups. Transfers of non-esterified cholesterol [6.8 (5.7-7.2) vs. 5.2 (4.5-6), p = 0.001], phospholipids [21.7 (20.4-22.2) vs. 8.2 (7.7-8.9), p = 0.0001] and triacylglycerol [3.7 (3.1-4) vs. 1.3 (0.8-1.7), p = 0.0001] were higher in marathon runners, but esterified-cholesterol transfer was similar. Immediately after the marathon, LDL- and HDL-cholesterol concentrations and apo A1 levels were unchanged, but apo B and triacylglycerol levels increased. Lipid transfer of non-esterified cholesterol [6.8 (5.7-7.2) vs. 5.8 (4.9-6.6), p = 0.0001], phospholipids [21.7 (20.4-22.2) vs. 19.1 (18.6-19.3), p = 0.0001], esterified-cholesterol [3.2 (2.2-3.8) vs. 2.3 (2-2.9), p = 0.02] and triacylglycerol [3.7 (3.1-4) vs. 2.6 (2.1-2.8), p = 0.0001] to HDL were all reduced immediately after the marathon but returned to baseline 72 h later. Running a marathon increased IL-6 and TNF-α levels, but after 72 h these values returned to baseline. Lipid transfer, except esterified-cholesterol transfer, was higher in marathon runners than in sedentary individuals, but the marathon itself acutely inhibited lipid transfer. In light of these novel observations, further study is required to clarify how these metabolic changes can influence HDL composition and anti-atherogenic function.

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Section: Discussionmentioning

confidence: 99%

Lipid Transfer to HDL is Higher in Marathon Runners than in Sedentary Subjects, but is Acutely Inhibited During the Run

Vaisberg

Bachi

Latrilha

et al. 2012

Lipids

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“…The HDL's particle size has been a target of many studies based on evaluation of cardiovascular risk. The study by Azevedo et al [22] showed that patients with coronary artery disease (CAD) had smaller HDL particles (8.7 ± 0.7 nm) than non-CAD group (9.7 ± 1.6 nm). In another study, was observed that high TG levels in patients with CAD were significantly associated with low HDL 2 (larger particles) with predominance of HDL 3 particles (smaller particles) [23].…”

Section: Discussionmentioning

confidence: 99%

Atherogenic Indices and HDL Particle Size as Laboratory Parameters to Evaluate Cardiovascular Risk in the Presence of Dyslipidemia

Santos¹,

Vieira²,

Deus³

et al. 2014

JBPC

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Dyslipidemia may influence enzymes and transfer proteins needed to the lipoprotein particle remodeling. Calculated indices and evaluation of lipoprotein particle size have widely been used to predict cardiovascular risk. The aim of this study was to evaluate HDL particle size and LDL particle size estimate based on TG/HDL-C as well as apoB/apoA-I ratio as possible marker and atherogenic indices, respectively, of cardiovascular disease risk in the presence of dyslipidemia. We evaluated 100 individuals of both gender, without treatment with lipid-lowering drugs, 27 normolipidemic and 73 dyslipidemic, such as isolated hypercholesterolemia (n = 16), isolated A. P. C. Santos et al. 25hypertriglyceridemia (n = 17), low HDL-C (n = 26) and mixed dyslipidemia (n = 14). The HDL particle size did not differ between groups. The TG/HDL-C ratio was higher in groups with isolated hypertriglyceridemia (4.2 ± 1.5), low HDL-C (5.2 ± 3.1) and mixed dyslipidemia (5.3 ± 1.6). The apoB/apoA-I ratio was increased in all groups of dyslipidemia (apoB/apoA-I > 0.5) when compared to normolipidemic (apoB/apoA-I = 0.5, p < 0.001). There was a positive linear correlation between the TG/HDL-C ratio and the apoB/apoA-I ratio in low HDL-C group (r = 0.507, p = 0.008, Spearman). The results suggest that the evaluations of lipoproteins particles remodeling markers and the use of calculated indices may contribute to the evaluation of cardiovascular disease risk when dyslipidemia take place.

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“…Isto foi encontrado em dois estudos usando pacientes não diabéticos e em um estudo usando pacientes com DM2. Os dois estudos sem pacientes diabéticos compararam: pacientes com DAC precoce versus pacientes sem DAC (Azevedo et al, 2011); e pacientes idosos com DAC versus pacientes idosos sem DAC (Couto et al, 2007). O estudo usando pacientes diabéticos comparou pacientes com DM2 e DAC versus pacientes com DM2 sem DAC (Sprandel et al, 2012).…”

Section: Lde Ldlunclassified

“…O estudo usando pacientes diabéticos comparou pacientes com DM2 e DAC versus pacientes com DM2 sem DAC (Sprandel et al, 2012). Na DAC em pacientes não diabéticos, a transferência de triglicerídeos também foi diminuída em relação aos controles (Couto et al, 2007;Azevedo et al, 2011). No entanto, em diabéticos tipo 2 com DAC, apesar de não haver diferença na transferência de triglicérides, quando comparada com os diabéticos tipo 2 sem DAC, houve também diminuição da transferência de colesterol esterificado para HDL nos pacientes com DM2 e DAC (Sprandel et al, 2012).…”

Section: Lde Ldlunclassified

Efeitos do controle glicêmico sobre os lípides séricos e na transferência lipídica para a HDL em pacientes com diabetes mellitus tipo 2: novos achados no status do colesterol não esterificado

Neto¹,

Giese²

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Th-P15:224 Simultaneous transfer to HDL of cholesterol, triglycerides and phospholipids in aging and coronary artery disease

Cited by 6 publications

References 0 publications

Lipid Transfer to HDL is Higher in Marathon Runners than in Sedentary Subjects, but is Acutely Inhibited During the Run

Lipid Transfer to HDL is Higher in Marathon Runners than in Sedentary Subjects, but is Acutely Inhibited During the Run

Atherogenic Indices and HDL Particle Size as Laboratory Parameters to Evaluate Cardiovascular Risk in the Presence of Dyslipidemia

Efeitos do controle glicêmico sobre os lípides séricos e na transferência lipídica para a HDL em pacientes com diabetes mellitus tipo 2: novos achados no status do colesterol não esterificado

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