TGF-β1 Gene Polymorphisms and Peritoneal Equilibration Test Results in CAPD Patients

Ebinç, Fatma Ayerden; Derici, Ülver; Gönen, Sevim; Reis, Kadriye Altok; Erten, Yasemin; Bali, Musa; Sindel, Şükrü; Arınsoy, Turgay

doi:10.1080/08860220701741684

Cited by 7 publications

(12 citation statements)

References 20 publications

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“…The role of non‐cytokine gene polymorphism on longitudinal change of peritoneal membrane function has been investigated in three previous studies 22–24 . Szeto et al .…”

Section: Discussionmentioning

confidence: 99%

“…The role of non-cytokine gene polymorphism on longitudinal change of peritoneal membrane function has been investigated in three previous studies. [22][23][24] Szeto et al found that plasminogen activator inhibitor-1 4G/5G was not associated with longitudinal 24-month change in peritoneal transport, 22 whereas vascular endothelial growth factor (VEGF-2578 AA) was associated with progressive increase in peritoneal transport during a one-year follow-up. 23 Ebinç et al reported that there was no relation between transforming growth factor-beta1 gene polymorphisms in codon 10 and 25 and longitudinal 24-month change in peritoneal transport.…”

Section: Discussionmentioning

confidence: 99%

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The Association between Interleukin 10 Gene Polymorphism -592 (A/C) and Peritoneal Transport in Patients Undergoing Peritoneal Dialysis

et al. 2011

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“…The role of non‐cytokine gene polymorphism on longitudinal change of peritoneal membrane function has been investigated in three previous studies 22–24 . Szeto et al .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Association between Interleukin 10 Gene Polymorphism -592 (A/C) and Peritoneal Transport in Patients Undergoing Peritoneal Dialysis

et al. 2011

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“…It is also unclear whether monitoring these cytokines is helpful. 11 The measurement of peritoneal membrane permeability is of utmost importance to determine the ultrafiltration failure and solute transport problems resulting from interstitial fibrosis and hyalinization of peritoneal membrane vessels. However, the measurement of peritoneal membrane permeability shows only the instant peritoneal status, not the progression.…”

Section: Introductionmentioning

confidence: 99%

The importance of ultrasonographic measurement of peritoneal wall thickness in pediatric chronic peritoneal dialysis patients

et al. 2015

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Loss of peritoneal function due to peritoneal fibrosing syndrome (PFS) is a major factor leading to treatment failure in chronic peritoneal dialysis (PD) patients. Although the precise biologic mechanisms responsible for these changes have not been defined, the general assumption is that alterations in peritoneal function are related to structural changes in the peritoneal membrane. Studies of the peritoneal membrane by non-invasive ultrasonography (US) in chronic PD patients are limited. The aim of the present study is to assess the relationship between functional parameters of peritoneum and peritoneal thickness measured by US in children treated by chronic PD. We recruited two groups of patients: 23 subjects (13 females, 10 males) on chronic PD (patient group) and 26 (7 females, 19 males) on predialysis out-patient follow-up (creatinine clearance: 20-60 mL/min/1.73 m 2 ) (control group). Age, sex, weight, height, body mass index (BMI), chronic PD duration, episodes of peritonitis and the results of peritoneal equilibration test (PET) were recorded. Hemoglobin (Hb), blood pressure (BP), left ventricular mass index (LVMI) and renal osteodystrophy (ROD) parameters were also obtained. The thickness of the parietal peritoneum was measured by trans-abdominal US in all children. Statistical analyses were performed by using Student's t and Pearson's correlation tests. Mean peritoneal thickness in chronic PD patients (1028.26 ± 157.26 mm) was significantly higher than control patients (786.52 ± 132.33 (R 2 ¼ 0.81, p50.05). No correlation was found between peritoneal thickness and Hb, BP, LVMI and ROD parameters. In conclusion, ultrasonographic measurement of peritoneal membrane thickness is a simple and non-invasive method in chronic PD children. This diagnostic tool likely enables to assess peritoneal structure and function in these patients.

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“…There have been several genetic studies of peritoneal solute transport rate in patients with PD. Polymorphisms of endothelial nitric oxide synthase, 16 receptor of advanced glycation end products 17 and transforming growth factor-βl 18 were reported to be involved in baseline transport status. In 2005, Gillerot et al 15 showed that the SNP of IL-6 (rs1800795) influenced baseline peritoneal permeability in Caucasian patients with PD.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, many studies have shown that genetic variants may play an important role in mechanisms contributing to the baseline variability in peritoneal transport. [15][16][17][18][19][20] It has been suggested that chronic inflammation mediated by various inflammatory cytokines may have an effect on peritoneal transport. 21 Studies have shown that the interleukin (IL)-6 level in peritoneal dialysates is associated with the peritoneal solute transport rate in patients with dialysis.…”

Section: Introductionmentioning

confidence: 99%

Possible role of IL-6 and TIE2 gene polymorphisms in predicting the initial high transport status in patients with peritoneal dialysis: an observational study

et al. 2016

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ObjectivesThe aim of this study was to investigate the effect of interleukin (IL)-6 and TIE2 gene polymorphisms on baseline peritoneal transport property.DesignAn observational study.SettingRenji Hospital in Shanghai, China.ParticipantsThis study included 220 patients with continuous ambulatory peritoneal dialysis (PD).Outcome measuresPatients were divided into 2 groups based on the results of an initial peritoneal equilibration test performed within 3 months of starting PD therapy: group 1 consisted of low/low average transporters (n=123), and group 2 consisted of high/high average transporters (n=97). We genotyped TIE2 and IL-6 polymorphisms and analysed their effects on baseline transport status.ResultsThe genotype AT in IL-6 Rs13306435 and the genotype CC in TIE2 Rs639225 were both negatively associated with a higher initial peritoneal transport status (IL-6 Rs13306435: OR=0.408, 95% CI 0.227 to 0.736; TIE2 Rs639225: OR=0.188, 95% CI 0.044 to 0.806).ConclusionsIL-6 and TIE2 polymorphisms are associated with baseline peritoneal transport property.

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TGF-β1 Gene Polymorphisms and Peritoneal Equilibration Test Results in CAPD Patients

Cited by 7 publications

References 20 publications

The Association between Interleukin 10 Gene Polymorphism -592 (A/C) and Peritoneal Transport in Patients Undergoing Peritoneal Dialysis

The Association between Interleukin 10 Gene Polymorphism -592 (A/C) and Peritoneal Transport in Patients Undergoing Peritoneal Dialysis

The importance of ultrasonographic measurement of peritoneal wall thickness in pediatric chronic peritoneal dialysis patients

Possible role of IL-6 and TIE2 gene polymorphisms in predicting the initial high transport status in patients with peritoneal dialysis: an observational study

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