Colistin-induced renal toxicity may be attributable to oxidative damage. The combined treatment of colistin plus NAC seems to have a beneficial role in restoration of the oxidant injury which may be related to its antioxidant effect.

Abstract

Abstract. To evaluate the relationship between the adiponectin levels and left ventricular mass index (LVMI) in uncomplicated obese subjects. Fifty-nine subjects were assigned to the obese (BMI≥30 kg/m 2 ) and 58 to the lean (BMI<30 kg/m 2 ) group. Plasma glucose, insulin, serum total cholesterol and high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, triglycerides and adiponectin were measured. Insulin resistance was determined by the Homeostasis Assessment Model (HOMA-IR). The left ventricular functions of all subjects were determined by 2D and pulse wave Doppler echocardiography. LVMI was calculated as left ventricular mass (LVM) normalized for height in m 2.7 . The obese group displayed significantly higher LVMI and late mitral inflow velocity. Thirty-three obese subjects met the criteria for left ventricular hypertrophy (LVH) and had lower serum adiponectin levels compared with obese subjects without LVH and lean subjects (p<0.05). Adiponectin was negatively correlated with LVMI (R: -0.277, p: 0.002). Furthermore, during the partial correlation analysis where HOMA-IR was controlled, the negative correlation between adiponectin and LVMI progressed (r: -0.283, p: 0.002). The linear regression analysis showed an independent relationship between LVMI and adiponectin. (β: -0.214, p: 0.01) Obesity is associated with LVH. This study showed direct influence of adiponectin on LVMI. OBESITY leads to serious changes in cardiac structure and functions [1]. These changes are characterized by an increase in left ventricular mass index (LVMI), diastolic dysfunction, and in advanced stages of the condition, systolic dysfunction [2]. It is currently believed that hemodynamic factors alone do not account for obesity-related cardiac structure abnormality. An investigation of possible metabolic inflammatory causes of left ventricular hypertrophy (LVH) in obesity may help the prevention and treatment of these changes [3].Recent studies have shown that adipose tissue acts like an endocrine organ and synthesizes various hormones. One of these hormones is adiponectin, which is believed to possess anti-atherogenic and anti-diabetic qualities [4]. Obesity or other obesity related complications are associated with decreased adiponectin levels [4], and thus is believed to play a role in the etiology of a number of diseases such as obesity, insulin resistance, hypertension, dyslipidemia, and atherosclerotic heart disease. Therefore, hypoadiponectinemia may be a factor in obesity-related LVH [5], which may be an independent effect or result of complications, such as obesity or obesity-related insulin resistance and hypertension [5]. Thus, an improvement in adiponectin levels can be expected to lower obesity-related morbidity and mortality [6]. However, there are few studies in

Background: Diabetic nephropathy (DN) is a leading cause of diabetes-related morbidity and mortality. The aim of this study was to evaluate the relationship of AGT M235T and apoprotein E (APO E) gene polymorphism with DN in Turkish patients of Type 2 diabetes, and to compare genotype and allele distributions among DN patients, non-DN patients, and healthy controls. Methods: AGT M235T and APO E genotype and allele analysis were performed in 111 DN patients, 108 non-DN patients, 106 healthy control subjects for APO E genotype, and 100 for AGT M235T genotype polymorphism. APO E and AGT M235T genotype were determined by RFLP-PCR. Results: The frequencies of APO E ε2/3, ε 3/3, ε 3/4 genotypes were 22.7%, 60%, 60%, respectively, among DN patients and 6.6%, 80%, 10.4%, respectively (p < 0.001), in the non-DN patients. The frequencies of AGT M235T MM, MT, TT genotypes among the same groups were 17%, 46%, 37% and 21%, 63%, 16%, respectively (p < 0.02). Having the ε2/3 genotype and TT genotype increased the risk for DN nephropathy [4.8-fold (95% CI: 1.94-11.67), 2.9-fold (95% CI: 1.27-6.69), respectively]. Conclusion: Our study has shown that AGT M235T TT genotype and APO E ε 2/3 genotype may be linked to a risk for DN among Turkish population.

Insulin resistance and fasting insulin is not associated with left ventricular hypertrophy in healthy people, independent of obesity. Obesity appears to be an independent risk factor for left ventricular hypertrophy.

No abstract

Objective The existence of microalbuminuria (MAU)

This study suggests that BG protects or ameliorates against contrast-induced nephropathy. Its beneficial effects may be similar to or greater than those of Nb or NAC.