Tetrathiomolybdate, a copper chelator inhibited imiquimod-induced skin inflammation in mice

Hsu, Peng-Yang; Yen, Hsu‐Heng; Yang, Tao-Hsiang; Su, Chih‐Ying

doi:10.1016/j.jdermsci.2018.08.003

Cited by 15 publications

(9 citation statements)

References 35 publications

(41 reference statements)

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“…Besides the utilization of natural antioxidant compounds, another way to counteract ROS production induced by environmental pollutants and UV radiation is the application of chelating agents in cosmetic formulations. Chelating agents can bind with metal ions, such as copper and iron, preventing them from chemically reacting with other substances [ 179 ]. Iron has been identified as one of the primary metals modulated by air pollutant exposure in human skin [ 180 , 181 ].…”

Section: Environmental Protection Strategiesmentioning

confidence: 99%

Ultraviolet Light Protection: Is It Really Enough?

Farris

Valacchi

2022

Antioxidants

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Our current understanding of the pathogenesis of skin aging includes the role of ultraviolet light, visible light, infrared, pollution, cigarette smoke and other environmental exposures. The mechanism of action common to these exposures is the disruption of the cellular redox balance by the directly or indirectly increased formation of reactive oxygen species that overwhelm the intrinsic antioxidant defense system, resulting in an oxidative stress condition. Altered redox homeostasis triggers downstream pathways that contribute to tissue oxinflammation (cross-talk between inflammation and altered redox status) and accelerate skin aging. In addition, both ultraviolet light and pollution increase intracellular free iron that catalyzes reactive oxygen species generation via the Fenton reaction. This disruption of iron homeostasis within the cell further promotes oxidative stress and contributes to extrinsic skin aging. More recent studies have demonstrated that iron chelators can be used topically and can enhance the benefits of topically applied antioxidants. Thus, an updated, more comprehensive approach to environmental or atmospheric aging protection should include sun protective measures, broad spectrum sunscreens, antioxidants, chelating agents, and DNA repair enzymes.

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Section: Environmental Protection Strategiesmentioning

confidence: 99%

Ultraviolet Light Protection: Is It Really Enough?

Farris

Valacchi

2022

Antioxidants

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“…Mice were smeared with 5% imiquimod ointment (active ingredient 3.2 mg day −1 ) on the right ear for 6 days to construct the psoriasis model (rashes and dandruff could be observed in the area treated with imiquimod). 62,63 After the model was successfully constructed, G2 (25 μL, 1 mM; Fig. 6 and Fig.…”

Section: Resultsmentioning

confidence: 99%

Hypochlorous acid triggered fluorescent probes forin situimaging of a psoriasis model

Wei

Liu

et al. 2022

J. Mater. Chem. B

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“…The 5 elements tested in the current study strongly influence the functions of skin, with effects on wound healing [ 22 , 23 ], scar formation and contraction [ 24 ], microvasculature blood flow [ 25 , 26 ], and immune function [ 27 ]. A deficiency of these 5 elements may cause skin lesions [ 28 – 30 ], while supplementation may lead to improved skin functions [ 21 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Lower Metal Element Levels in Hypertrophic Scars: A Potential Mechanism of Aberrant Cicatrix Hyperplasia

et al. 2020

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Background We investigated levels of the metal elements Ca, Mg, Zn, Fe, and Cu in blood, normal skin (NS), and different types of scar tissue and aimed to elucidate the pathogenesis of hypertrophic scars (HS). Material/Methods Tissue specimens were excised from 3 groups of research participants: scar-free, flat scar (FS), and HS groups. Levels of the study elements were measured in blood, NS, and scar tissues with a spectrophotometer. The levels in plasma or in different types of specimens were compared among subgroups. In the FS and HS groups, levels were compared between the scar tissue and NS of each individual. In addition, element differences in exposed and unexposed areas of NS were investigated in the scar-free group. HS fibroblasts (HFB) were cultured in medium with various reduced levels of metal elements to determine the influence of metal elements on fibroblast growth. Results Levels of trace elements, including Zn, Fe, and Cu, were significantly lower in HS than in FS. The levels of Ca, Zn, Fe, and Cu were markedly lower in HS than in the patients’ own NS, while the Cu/Zn ratio was higher. However, no such difference was observed in the FS group. No significant difference in element levels was found in either plasma or NS among the 3 groups. Reduced levels of the elements promoted HFB proliferation within 24 h while an inhibition effect was observed at 72 h. Conclusions Our findings indicate reduced levels of metal elements in part of the healing microenvironment, suggesting that decreased metal levels may be involved in the pathogenesis of HS.

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Tetrathiomolybdate, a copper chelator inhibited imiquimod-induced skin inflammation in mice

Abstract: These findings are strong evidence that TM can inhibit psoriasis in the model.

Cited by 15 publications

References 35 publications

Ultraviolet Light Protection: Is It Really Enough?

Ultraviolet Light Protection: Is It Really Enough?

Hypochlorous acid triggered fluorescent probes forin situimaging of a psoriasis model

Lower Metal Element Levels in Hypertrophic Scars: A Potential Mechanism of Aberrant Cicatrix Hyperplasia

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