Tetracyclines and their metabolites in egg white and yolk

Zurhelle, Georg; Petz, Michael; Müller-Seitz, Erika; Siewert, Eike

doi:10.1007/s002170050420

Cited by 3 publications

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“…With eggs from the medication period we observed a strong fluorescence of the egg shell after excitation with UV light as reported by Lindgren et al (1970). When the medication was stopped, the egg shells were nonfluorescent (Zurhelle et al, 1999). The intensity was highest after feeding CTC and lower after feeding a diet with identical concentrations of TC or OTC.…”

Section: Resultssupporting

confidence: 79%

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Metabolites of Oxytetracycline, Tetracycline, and Chlortetracycline and Their Distribution in Egg White, Egg Yolk, and Hen Plasma

Zurhelle

Petz

Mueller-Seitz

et al. 2000

J. Agric. Food Chem.

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4-epioxytetracycline and N-demethyloxytetracycline, as metabolites of oxytetracycline (OTC), 4-epitetracycline and N-demethyltetracycline, as metabolites of tetracycline (TC), and 4-epichlortetracycline, isochlortetracycline (ICTC), 4-epi-ICTC, and N-demethyl-ICTC, as metabolites of chlortetracycline (CTC), were detected in egg yolk and plasma obtained from feeding studies with either OTC, TC, or CTC. In egg white, only OTC, TC with its 4-epimer, and ICTC with its 4-epimer were detected in substantial concentrations. The ratios of epimerization and N-demethylation in the eggs did not change during the medication period. The samples were analyzed by an automated HPLC system (ASTED) with UV, fluorescence, or MS-MS detection.

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Section: Resultssupporting

confidence: 79%

“…In an attempt to produce such a reference material, the first dose of medication was chosen to obtain residue levels in whole eggs close to the MRL. Analyzing the eggs from these feeding experiments disclosed the unexpected presence of several metabolites of the tetracyclines formed in vivo (Zurhelle et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Metabolites of Oxytetracycline, Tetracycline, and Chlortetracycline and Their Distribution in Egg White, Egg Yolk, and Hen Plasma

Zurhelle

Petz

Mueller-Seitz

et al. 2000

J. Agric. Food Chem.

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“…Besides, their degradation products are also toxic to some degree [17] . Furthermore, because of the complexation of tetracycline with Ca 2+ [18] , relatively high level of antibiotic residues enrich in the animal bones when animals are bred with tetracycline in a long period [19] , as well as in fish [4,20] , meat [21][22][23] , eggs [24][25][26][27] and milk [28,29] . Therefore, the detection of tetracycline is closely linked to human life.…”

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confidence: 99%

Investigations on the amalgamation of gold nanorods by iodine and the detection of tetracycline

Wang

Huang

2009

Sci. China Ser. B-Chem.

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The morphological transformation process of gold nanorods (Au-NRs) resulting from the reaction between tetracycline and iodine was monitored by the plasmon resonance absorption (PRA) spectra and the scanning electron microscope (SEM) images. It was found that iodine could fuse Au-NRs into sphericity with the lower aspect ratio and blue shift of the longitudinal PRA band. It was found, however, that the presence of tetracycline, since it can react with I 2 , decreases the effective concentration of I 2 and its fusion effect on Au-NRs. As a result, the longitudinal PRA of Au-NRs shifts to longer wavelength linearly with increasing the concentration of tetracycline. With that, tetracycline can be detected in the range of 5.0×10 −5 -5.0×10 −4 mol·L −1 , with a limit of determination (LOD) of 2.4×10 −6 mol·L −1 (3σ). Most foreign substances in the samples did not interfere in the detection, and tetracycline in the synthetic samples could be detected with the recovery in the range of 92.8%-107.2%, and RSD lower than 4.3%. The concentration of tetracycline in milk detected with standard addition method was so low that it accorded with the safety regulation.gold nanorods, iodine, tetracycline hydrochloride, plasmon resonance absorption Due to the broad range of activity against pathogens and low cost, tetracycline antibiotics are widely used against bacteria infection [1][2][3] or as feed additives for growth promotion in veterinary practice [4,5] . Medically, tetracycline can be employed to treat gallbladder disease [6,7] , malignant pleural effusions [8 -12] or periodontal disease [13] . However, relatively high levels of antibiotic residues may lead bacteria to resist against antimicrobial reagents [14,15] , or can bring about allergic reactions in some hypersensitive individuals [16] . Besides, their degradation products are also toxic to some degree [17] . Furthermore, because of the complexation of tetracycline with Ca 2+ [18] , relatively high level of antibiotic residues enrich in the animal bones when animals are bred with tetracycline in a long period [19] , as well as in fish [4,20] , meat [21][22][23] , eggs [24][25][26][27] and milk [28,29] . Therefore, the detection of tetracycline is closely linked to human life.By now, a variety of methods have been applied to detecting tetracycline, such as microorganism control experiment [30] , immunoreactions [31] , fluorescence method [32] , capillary electrophoresis [20] and high-performance liquid chromatography (HPLC) [33][34][35] . All of them supply the structural information or pharmacologic function of tetracycline, but microorganism control experiment lasts too long without sensitivity, immunoreactions need the complicated and long-term operation, capillary electrophoresis is carried out with poor recurrence and HPLC requires costly instrument and professional operation. All of these limitations confine the applications of these methods. Therefore, it is necessary to develop a rapid and simple method for determination of tetracycline.Our previous study [36...

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Automated residue analysis of tetracyclines and their metabolites in whole egg, egg white, egg yolk and hen’s plasma utilizing a modified ASTED system

Zurhelle

Müller-Seitz

Petz

2000

Journal of Chromatography B: Biomedical Sciences and Applicatio

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Tetracyclines and their metabolites in egg white and yolk

Cited by 3 publications

References 0 publications

Metabolites of Oxytetracycline, Tetracycline, and Chlortetracycline and Their Distribution in Egg White, Egg Yolk, and Hen Plasma

Metabolites of Oxytetracycline, Tetracycline, and Chlortetracycline and Their Distribution in Egg White, Egg Yolk, and Hen Plasma

Investigations on the amalgamation of gold nanorods by iodine and the detection of tetracycline

Automated residue analysis of tetracyclines and their metabolites in whole egg, egg white, egg yolk and hen’s plasma utilizing a modified ASTED system

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