Automated residue analysis of tetracyclines and their metabolites in whole egg, egg white, egg yolk and hen’s plasma utilizing a modified ASTED system

Zurhelle, Georg; Müller-Seitz, Erika; Petz, Michael

doi:10.1016/s0378-4347(99)00477-6

Cited by 44 publications

(25 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several papers have been published concerning the analysis of TCs by MS/MS which detail the parent ion selection and fragmentation mechanism [13][14][15][16]. The fragmentation pathways of TCs have been described by Kamel et al [16], and were mainly explained by the losses of H 2 O (18 u), NH 3 (17 u), CO (28 u) and NH(CH 3 ) 2 (45 u).…”

Section: Esi-ms/ms and Confirmationmentioning

confidence: 99%

“…There have been few published reports concerning drug residues in royal jelly [6,7]. Many liquid chromatography methods have been published for the determination of TCs in various food matrices [8][9][10][11][12][13][14][15]. Ishii et al reported a method to determine the TCs in royal jelly by using 2% metaphosphoric acid as the deproteinizing reagent.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Analysis of tetracycline residues in royal jelly by liquid chromatography–tandem mass spectrometry

Ding

et al. 2008

Journal of Chromatography B

View full text Add to dashboard Cite

Section: Esi-ms/ms and Confirmationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analysis of tetracycline residues in royal jelly by liquid chromatography–tandem mass spectrometry

Ding

et al. 2008

Journal of Chromatography B

View full text Add to dashboard Cite

“…The analytical techniques reported in the literature for the monitoring and determination of tetracycline antibiotics and other veterinary drugs in eggs are mostly chromatographic, including high performance liquid chromatography (HPLC) with ultraviolet (UV) [7,[11][12][13], fluorescence [14], or mass spectrometry (MS/MS) [1][2][3][4][15][16][17][18][19][20] detection, and ultrahigh-pressure liquid chromatography-tandem mass spectrometry (UHPL-MS/MS) [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…The most important are solvent extraction [5,16], liquid-liquid extraction (LLE) [3], solidphase extraction (SPE) [1,2,4,5,11,14,15,17,19], ultrasonic-assisted extraction (UAE) [2], and pressurized liquid extraction (PLE) [6,12]. Furthermore, SPE modifications using molecularly imprinted solid-phase extraction (MISPE) [13,20] and magnetic molecularly imprinted polymer solidphase extraction (MIP-SPE) [18] have also been used as extraction methods.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-assisted dispersive liquid–liquid microextraction of tetracycline drugs from egg supplements before flow injection analysis coupled to a liquid waveguide capillary cell

Pérez-Rodríguez

Pezza

2016

Anal Bioanal Chem

View full text Add to dashboard Cite

A simple, rapid, and efficient ultrasound-assisted dispersive liquid-liquid microextraction (US-DLLME) method was developed for extraction of tetracycline residues from egg supplement samples, with subsequent determination by flow injection analysis (FIA) coupled to a liquid waveguide capillary cell (LWCC) and a controlled temperature heating bath. Tetracyclines react with diazotized p-sulfanilic acid, in a slightly alkaline medium, to form azo compounds that can be measured at 435 nm. The reaction sensitivity improved substantially (5.12-fold) using an in-line heating temperature of 45 °C. Multivariate methodology was used to optimize the factors affecting the extraction efficiency, considering the volumes of extraction and disperser solvents, sonication time, extraction time, and centrifugation time. Good linearity in the range 30-600 μg L(-1) was obtained for all the tetracyclines, with regression coefficients (r) higher than 0.9974. The limits of detection ranged from 6.4 to 11.1 μg L(-1), and the recoveries were in the range 85.7-96.4 %, with relative standard deviation lower than 9.8 %. Analyte recovery was improved by approximately 6 % when the microextraction was assisted by ultrasound. The results obtained with the proposed US-DLLME-FIA method were confirmed by a reference HPLC method and showed that the egg supplement samples analyzed were suitable for human consumption.

show abstract

“…Besides, their degradation products are also toxic to some degree [17] . Furthermore, because of the complexation of tetracycline with Ca 2+ [18] , relatively high level of antibiotic residues enrich in the animal bones when animals are bred with tetracycline in a long period [19] , as well as in fish [4,20] , meat [21][22][23] , eggs [24][25][26][27] and milk [28,29] . Therefore, the detection of tetracycline is closely linked to human life.…”

mentioning

confidence: 99%

Investigations on the amalgamation of gold nanorods by iodine and the detection of tetracycline

Wang

Huang

2009

Sci. China Ser. B-Chem.

View full text Add to dashboard Cite

The morphological transformation process of gold nanorods (Au-NRs) resulting from the reaction between tetracycline and iodine was monitored by the plasmon resonance absorption (PRA) spectra and the scanning electron microscope (SEM) images. It was found that iodine could fuse Au-NRs into sphericity with the lower aspect ratio and blue shift of the longitudinal PRA band. It was found, however, that the presence of tetracycline, since it can react with I 2 , decreases the effective concentration of I 2 and its fusion effect on Au-NRs. As a result, the longitudinal PRA of Au-NRs shifts to longer wavelength linearly with increasing the concentration of tetracycline. With that, tetracycline can be detected in the range of 5.0×10 −5 -5.0×10 −4 mol·L −1 , with a limit of determination (LOD) of 2.4×10 −6 mol·L −1 (3σ). Most foreign substances in the samples did not interfere in the detection, and tetracycline in the synthetic samples could be detected with the recovery in the range of 92.8%-107.2%, and RSD lower than 4.3%. The concentration of tetracycline in milk detected with standard addition method was so low that it accorded with the safety regulation.gold nanorods, iodine, tetracycline hydrochloride, plasmon resonance absorption Due to the broad range of activity against pathogens and low cost, tetracycline antibiotics are widely used against bacteria infection [1][2][3] or as feed additives for growth promotion in veterinary practice [4,5] . Medically, tetracycline can be employed to treat gallbladder disease [6,7] , malignant pleural effusions [8 -12] or periodontal disease [13] . However, relatively high levels of antibiotic residues may lead bacteria to resist against antimicrobial reagents [14,15] , or can bring about allergic reactions in some hypersensitive individuals [16] . Besides, their degradation products are also toxic to some degree [17] . Furthermore, because of the complexation of tetracycline with Ca 2+ [18] , relatively high level of antibiotic residues enrich in the animal bones when animals are bred with tetracycline in a long period [19] , as well as in fish [4,20] , meat [21][22][23] , eggs [24][25][26][27] and milk [28,29] . Therefore, the detection of tetracycline is closely linked to human life.By now, a variety of methods have been applied to detecting tetracycline, such as microorganism control experiment [30] , immunoreactions [31] , fluorescence method [32] , capillary electrophoresis [20] and high-performance liquid chromatography (HPLC) [33][34][35] . All of them supply the structural information or pharmacologic function of tetracycline, but microorganism control experiment lasts too long without sensitivity, immunoreactions need the complicated and long-term operation, capillary electrophoresis is carried out with poor recurrence and HPLC requires costly instrument and professional operation. All of these limitations confine the applications of these methods. Therefore, it is necessary to develop a rapid and simple method for determination of tetracycline.Our previous study [36...

show abstract

Automated residue analysis of tetracyclines and their metabolites in whole egg, egg white, egg yolk and hen’s plasma utilizing a modified ASTED system

Cited by 44 publications

References 11 publications

Analysis of tetracycline residues in royal jelly by liquid chromatography–tandem mass spectrometry

Analysis of tetracycline residues in royal jelly by liquid chromatography–tandem mass spectrometry

Ultrasound-assisted dispersive liquid–liquid microextraction of tetracycline drugs from egg supplements before flow injection analysis coupled to a liquid waveguide capillary cell

Investigations on the amalgamation of gold nanorods by iodine and the detection of tetracycline

Contact Info

Product

Resources

About