Tetracycline hydrochloride loaded regenerated cellulose composite membranes with controlled release and efficient antibacterial performance

Shao, Wei; Wang, Shuxia; Liu, Xiufeng; Liu, Hui; Wu, Jimin; Zhang, Rui; Min, Huihua; Huang, Min

doi:10.1039/c5ra23409c

Cited by 15 publications

(17 citation statements)

References 36 publications

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“…Cellulose aerogels were prepared by a facile solution casting method [ 32 ]. A transparent 5.8% cellulose solution was prepared by dissolving microcrystalline cellulose powder into 9% NaOH and then stirred at 4 °C for 2 h. The cellulose solution was casted into the template on glass plate, and soaked in a de-ionized water bath for 30 min, followed by rinsing with de-ionized water.…”

Section: Methodsmentioning

confidence: 99%

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Morphological, Release and Antibacterial Performances of Amoxicillin-Loaded Cellulose Aerogels

Chen

et al. 2018

Molecules

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Cellulose has been widely used in the biomedical field. In this study, novel cellulose aerogels were firstly prepared in a NaOH-based solvent system by a facile casting method. Then amoxicillin was successfully loaded into cellulose aerogels with different loadings. The morphology and structure of the cellulose aerogels were characterized using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The drug release and antibacterial activities were also evaluated. The drug release results showed that cellulose aerogels have controlled amoxicillin release performance. In vitro antibacterial assay demonstrated that the cellulose aerogels exhibited excellent antibacterial activity with the amoxicillin dose-dependent activity. Therefore, the developed cellulose aerogels display controlled release behavior and efficient antibacterial performance, thus confirming their potential for biomedical applications.

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Section: Methodsmentioning

confidence: 99%

“…The aerogels were cut into round pieces in diameter of 10 mm. The release behaviors of amoxicillin were studied in PBS buffers [ 32 ]. At specific time points, an aliquot of 3.5 mL was collected from each solution and the absorbance was then measured at 225 nm by a SHIMADZU ultraviolet (UV) 2450 spectrophotometer.…”

Section: Methodsmentioning

confidence: 99%

Morphological, Release and Antibacterial Performances of Amoxicillin-Loaded Cellulose Aerogels

Chen

et al. 2018

Molecules

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“…Tetracycline loading was performed by submerging bacterial cellulose in the antibiotic solution for 24 h under constant agitation. The results showed an initial exponential release for the first 3 h but plateaued to a steady release for the remaining 93 h [ 47 ]. In another study, saturating bacterial cellulose loaded with fusidic acid over 24 h of submersion showed antimicrobial activity against Staphylococcus aureus .…”

Section: Bacterial Cellulose As a Biotechnological Materialsmentioning

confidence: 99%

“…As is the usual case, the most common method of loading drugs in BC membranes is via immersion in the drug solution usually following lyophilisation to allow for maximum absorption of the drug [46]. The most common drugs to be incorporated into bacterial cellulose are anti-inflammatory drugs, such as ibuprofen and diclofenac, and antimicrobial drugs [47][48][49][50][51][52]. The efficiency of bacterial cellulose as a drug delivery material can be improved to provide additional properties and functions by exploiting tensile strength and water uptake to load the cellulose with antimicrobial compounds such as antibiotics [53,54].…”

Section: Bacterial Cellulose As a Biotechnological Materials 41 Drug Deliverymentioning

confidence: 99%

Recent Advances and Applications of Bacterial Cellulose in Biomedicine

et al. 2021

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Bacterial cellulose (BC) is an extracellular polymer produced by Komagateibacter xylinus, which has been shown to possess a multitude of properties, which makes it innately useful as a next-generation biopolymer. The structure of BC is comprised of glucose monomer units polymerised by cellulose synthase in β-1-4 glucan chains which form uniaxially orientated BC fibril bundles which measure 3–8 nm in diameter. BC is chemically identical to vegetal cellulose. However, when BC is compared with other natural or synthetic analogues, it shows a much higher performance in biomedical applications, potable treatment, nano-filters and functional applications. The main reason for this superiority is due to the high level of chemical purity, nano-fibrillar matrix and crystallinity. Upon using BC as a carrier or scaffold with other materials, unique and novel characteristics can be observed, which are all relatable to the features of BC. These properties, which include high tensile strength, high water holding capabilities and microfibrillar matrices, coupled with the overall physicochemical assets of bacterial cellulose makes it an ideal candidate for further scientific research into biopolymer development. This review thoroughly explores several areas in which BC is being investigated, ranging from biomedical applications to electronic applications, with a focus on the use as a next-generation wound dressing. The purpose of this review is to consolidate and discuss the most recent advancements in the applications of bacterial cellulose, primarily in biomedicine, but also in biotechnology.

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“…They show a blue shift due to the formation of ionic bonding between -COO - and Ca 2+ in this study. In the FTIR spectrum of TCH (curve g), the peaks located at 1665 cm −1 , 1617 cm −1 , 1590 cm −1 , 1545 cm −1 and 1440 cm −1 are assigned to the C=O vibration of amide I, the C=O vibration of A-ring, the C=O vibration of C-ring, the N-H deformation of amide II and the C=C vibration of aromatic ring, respectively [ 31 ]. For TCH-loaded G/SA sponges (curves b–f), the intensity of peak at 1545 cm −1 increases with TCH loading raising although most characteristic peaks of TCH overlaps with the peaks of G/SA.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Antibacterial Gelatin/Sodium Alginate Sponges and Their Antibacterial Activity

Wen

Zhu

et al. 2020

Polymers

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In the present study, sponges with the antibiotic tetracycline hydrochloride (TCH) loaded into alginate incorporated with gelatin (G/SA) were fabricated. The G/SA sponges were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and thermogravimetric (TG) analysis. G/SA sponges show a three-dimensional network structure with high porosity. An excellent swelling behavior and a controlled TCH release performance are observed from G/SA sponges. Moreover, they exhibit good antibacterial activity against both Gram-positive and Gram-negative bacteria.

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Tetracycline hydrochloride loaded regenerated cellulose composite membranes with controlled release and efficient antibacterial performance

Abstract: Fabrication of cellulose based composites with controlled release and efficient antibacterial performances is of general interest in biomedical areas.

Cited by 15 publications

References 36 publications

Morphological, Release and Antibacterial Performances of Amoxicillin-Loaded Cellulose Aerogels

Morphological, Release and Antibacterial Performances of Amoxicillin-Loaded Cellulose Aerogels

Recent Advances and Applications of Bacterial Cellulose in Biomedicine

Synthesis of Antibacterial Gelatin/Sodium Alginate Sponges and Their Antibacterial Activity

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